A5100414956- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- RNA Research and Splicing
- Enzyme Production and Characterization
- Neuroscience and Neuropharmacology Research
- Protein Degradation and Inhibitors
- Amino Acid Enzymes and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Cancer Mechanisms and Therapy
- Metabolomics and Mass Spectrometry Studies
- Hepatitis B Virus Studies
- RNA and protein synthesis mechanisms
- Ion channel regulation and function
- Bone Metabolism and Diseases
Guangxi Medical University
2025
Fudan University Shanghai Cancer Center
2023-2024
Shanghai Medical College of Fudan University
2023-2024
Shanghai Cancer Institute
2023-2024
Wuxi No.2 People's Hospital
2024
Nanjing Medical University
2020-2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Central South University
2020-2022
Eastern Hepatobiliary Surgery Hospital
2018-2021
Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with high aggressiveness and extremely poor prognosis. The role of circular RNAs (circRNAs) in ICC carcinogenesis progression remains to be determined.CircRNA microarray was performed screen significantly upregulated circRNAs paired non-tumor tissues. Colony formation, transwell, xenograft models were used examine the proliferation metastasis. RNA pulldown, mass spectrometry, chromatin immunoprecipitation, RNA-binding protein...
A reduced incidence of microvascular invasion (MVI) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) may be associated with a decreased risk early tumor recurrence and better survival after partial hepatectomy.To examine the association preoperative antiviral treatment (AVT) incidences MVI posthepatectomy HBV-related HCC.Data on cohort 2362 patients who underwent R0 resection for HCC between January 2008 April 2010 at Eastern Hepatobiliary Surgery Hospital, Second Military...
BackgroundSeveral studies have noted that the discriminatory ability and stratification performance of AJCC 8th edition staging system is not entirely satisfactory. We aimed to improve American Joint Committee on Cancer (AJCC) for intrahepatic cholangiocarcinoma (ICC).MethodsA multicentric database from three Chinese mainland centers (n = 1601 patients) was used modify system. This modified TNM (mTNM) then validated using SEER 761 patients). A new system, by incorporating serum tumor markers...
Background: This study developed a novel inflammation score system to predict survival outcomes using preoperational inflammatory markers in hepatocellular carcinoma (HCC) after surgery.Materials and Methods: An was five preoperative based on the clinical data of 455 HCC patients (training cohort) receiving radical resection Eastern Hepatobiliary Surgery Hospital.The validated cohort from different hospital (external validation).Kaplan-Meier curves log-rank test were used compare with...
Abstract Pancreatic cancer cells have a much higher metabolic demand than that of normal cells. However, the abundant interstitium and lack blood supply determine nutrients in tumour microenvironment. Although pancreatic has been reported to extra for proliferation through autophagy other means, specific regulatory mechanisms not yet elucidated. In this study, we focused on transcription factor EB (TFEB), key regulation autophagy, explore its effect phenotype role unique amino acid...
Limited research has focused on the role of dihydrouridine synthases (DUS) family members in human tumors. Our previous findings indicated an impact synthase 4 like (DUS4L) cell proliferation and apoptosis lung adenocarcinoma (LUAD) A549 cell, yet its broader functions regulatory mechanisms LUAD remain elusive.
Abstract Background: Compared to physical and chemical methods, microbial lignocellulosic degradation is a green process. Bacillus an excellent organic matter degrader, it has exhibited various abilities required for lignocellulose degradation, including the of cellulose, hemicellulose lignin. Several B. velezensis strains encode lignocellulosases. However, their usefulness based on ability transform biomass not been appreciated. Genomic, comprehensive comparative genomic secretomic analyses...
Abstract Background: Circular RNAs (circRNAs) have emerged as a new subclass of regulatory that exert critical roles in various cancers. Cancer stem cells (CSCs), small subset cancer cells, are believed to possess the capacities initiate tumorigenesis and promote progression. Although accumulating evidences suggested with CSC-like properties crucial for malignance process gastric (GC), it remains inexplicit whether circRNAs interrelated acquisition GC. Methods: circFAM73A expression was...
Abstract Background Circular RNAs (circRNAs) play an important regulatory role in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), but they have not been sufficiently studied. Methods The high expression circRILPL1 NPC tissues was confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) situ hybridization (ISH). migration, invasion, proliferation, mechanical properties cells were detected using wound healing, transwell, MTT, colony formation assays, atomic...
Abstract Bacillus is an excellent organic matter degrader, and it has exhibited various abilities required for lignocellulose degradation. Several B. velezensis strains encode lignocellulosases however their usefulness based on ability to transform biomass not been appreciated. In the present study, genomic, comprehensive comparative genomic secretomic analyses were used clarify lignocellulose-degrading potential of these bacteria. The complete genomes 20 endophytic strain, LC1, analysed...