A5031875642- Mechanical Circulatory Support Devices
- Cardiac Ischemia and Reperfusion
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Anesthesia and Neurotoxicity Research
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- Intensive Care Unit Cognitive Disorders
- Atrial Fibrillation Management and Outcomes
- COVID-19 and healthcare impacts
- Inflammasome and immune disorders
- Infective Endocarditis Diagnosis and Management
- Peptidase Inhibition and Analysis
- Cardiovascular Issues in Pregnancy
- Vascular Procedures and Complications
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
Lanzhou University Second Hospital
2020-2024
Lanzhou University
2020-2024
Melittin, a naturally occurring polypeptide found in bee venom, has been recognized for its potential anti-tumor effects, particularly the context of lung cancer. Our previous study focused on impact human adenocarcinoma cells A549, revealing that melittin induces intracellular reactive oxygen species (ROS) burst and oxidative damage, resulting cell death. Considering significant role mitochondria maintaining redox levels ROS, we further examined involvement mitochondrial damage...
Limited research has focused on the role of dihydrouridine synthases (DUS) family members in human tumors. Our previous findings indicated an impact synthase 4 like (DUS4L) cell proliferation and apoptosis lung adenocarcinoma (LUAD) A549 cell, yet its broader functions regulatory mechanisms LUAD remain elusive.
Venovenous extracorporeal membrane oxygenation (VV ECMO) is now considered a reasonable option to salvage acute respiratory distress syndrome (ARDS). However, we lack rodent model for experimental studies. This study was undertaken establish an animal of VV ECMO in ARDS rats.A total 18 Sprague-Dawley (SD) rats (350 ± 50 g) were used this study. Using rat oleic acid (OA)-induced ARDS, established through cavoatrial cannulation the right jugular vein venous drainage and reinfusion with...
Although venovenous extracorporeal membrane oxygenation (VV ECMO) is a reasonable salvage treatment for acute respiratory distress syndrome (ARDS), it requires sedating the patient. Sevoflurane and propofol have pulmonary protective immunomodulatory properties. This study aimed to compare effectiveness of sevoflurane on rats with induced ARDS undergoing VV ECMO.
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used in high-risk acute myocardial infarction (AMI) patients with promising outcomes. However, the underlying molecular mechanisms remain unknown and a VA-ECMO animal model not yet established. The purpose of this study was to establish AMI rats evaluate long-term cardiac function.We first established 20 Sprague-Dawley (SD) by ligating left anterior descending coronary artery, while five underwent thoracotomy form...
Myocardial ischemia causes myocardial inflammation. Research indicates that the venoarterial extracorporeal membrane oxygenation (VA ECMO) provides cardiac support; however, inflammatory response caused by remains unresolved. Dexamethasone (Dex), a broad anti-inflammatory agent, exhibits cardioprotective effect. This study aims to investigate effect of Dex on rat model acute infarction (AMI) supported VA ECMO. Male Sprague-Dawley rats (300–350 g) were randomly divided into three groups: Sham...
Neurologic complications seriously affect the survival rate and quality of life in patients with extracorporeal cardiopulmonary resuscitation (ECPR) undergoing cardiac arrest. This study aimed to repurpose selective hypothermic cerebral perfusion (SHCP) as a novel approach protect brains these patients.Rats were randomly allocated Sham, ECPR, SHCP combined ECPR (CP-ECPR) groups. In group, circulatory was performed at 6 minutes after asphyxial arrest by membrane oxygenation. The vital signs...
The destruction of the pulmonary epithelial barrier in acute respiratory distress syndrome is caused by damage alveolar cells. Oroxin A an effective flavonoid component derived from medicinal plant Oroxylum indicum (L.) Kurz. In this study, oleic acid (OA)-induced A549 cell injury model was established vitro to explore protective mechanism A. experiment divided into following groups: control, OA and + group. OA-induced dose (time)-dependent detected CCK-8 assay. protein mRNA expression...
Background: Extracorporeal life support echniques as an Adjunct to Advanced Cardiac Life Support is usually suitable for complex heart surgery such cardiopulmonary bypass (CPB). Cerebral perfusion a clinically feasible neuroprotective strategy; however, the lack of reliable small animal model. Methods: Based on rat model ECLS we evaluate effects ECLS-CP using HE staining, Nissl TUNEL staining and ELISA. Result: We found that combined with cerebral did not cause brain injury immune...
Background In recent years, dexamethasone (Dex) has been used to treat acute respiratory distress syndrome (ARDS) in patients with COVID-19 and achieved promising outcomes. Venovenous extracorporeal membrane oxygenation (VV ECMO) support for ARDS increased significantly worldwide. However, it remains unknown whether Dex could improve the efficiency of VV ECMO reduce lung injury. Here, we investigate combined rats injury (ALI). Methods We established oleic acid (OA)-treated ALI administered...
Abstract Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is now considered a reasonable option to salvage acute respiratory distress syndrome (ARDS). However, we lack rodent model for experimental studies. This study was undertaken establish an animal of VV-ECMO in ARDS rats.Methods: Fifteen Sprague-Dawley (SD) rats (350 ± 50 g) were used this study. Using rat oleic acid (OA)-induced ARDS, established through bi-caval cannulation the right jugular vein venous drainage...
The authors reported no conflicts of interest.The Journal policy requires editors and reviewers to disclose interest decline handling or reviewing manuscripts for which they may have a conflict interest. this article We appreciate the thoughtful comments related our recent study team would certainly be interested in studying clinical data from Condello's1Condello I. Impact between favorable unfavorable criteria initiating ECPR outcomes.J Thorac Cardiovasc Surg Open. 2023; 13: 214Scopus (1)...
Abstract Malignant cancer exhibits a severe imbalance between the active of immune response and tolerance. And different connection establishment deficiency tumor is still unknown entirely. Here, we used ten clustering algorithms based on five cells infiltration matrix to identified two specific molecular subtypes determine its potential clinical outcomes effect. The cluster A subtype can be called cold inflammatory subtype, which revealed worst prognosis. B as hot with high activated...
Abstract Lung cancer is the most common of malignant cancers which represents poor prognosis and high invasive. However, reliable genes signature differential between genetic epigenetic are remain unclear. Here, we confirmed 78 A to construct a model predicted activity tumorigenesis-related pathways. The score based on expression correlation with cell cycle proliferation activity. Based median score, lung adenocarcinoma patients were divided into two cohorts presents different prognosis,...
Abstract Background: Acute respiratory distress syndrome (ARDS), a clinical resulting from intrapulmonary and/or extrapulmonary causes, is characterized by refractory hypoxemia. Currently, venovenous extracorporeal membrane oxygenation (VV ECMO) considered as reasonable alternative to salvage ARDS, but it requires sedation of the patient. Several studies suggest that anesthetics, such sevoflurane and propofol, have lung protective immunomodulatory functions. The aim this study was explore...