A5009611188- Mechanical Circulatory Support Devices
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Traditional Chinese Medicine Analysis
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Cardiac Valve Diseases and Treatments
- Diet, Metabolism, and Disease
- Pulmonary Hypertension Research and Treatments
- Pediatric Urology and Nephrology Studies
- Cardiovascular and exercise physiology
- Hippo pathway signaling and YAP/TAZ
- Metabolomics and Mass Spectrometry Studies
- Immune Response and Inflammation
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Cardiac, Anesthesia and Surgical Outcomes
- Inflammasome and immune disorders
- Ureteral procedures and complications
- Inflammation biomarkers and pathways
- Autophagy in Disease and Therapy
- Intensive Care Unit Cognitive Disorders
Second Affiliated Hospital of Zhejiang University
2024
Lanzhou University
2020-2023
Lanzhou University Second Hospital
2020-2023
University of Science and Technology of China
2023
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Hainan Medical University
2022
Weatherford College
2021
Soochow University
2021
Second Affiliated Hospital of Soochow University
2021
Acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar–capillary barrier, resulting in severe alveolar edema and inflammation. D-tagatose (TAG) a low-calorie fructose isomer with diverse biological activities whose role ARDS has never been explored. We found that TAG protects lung tissues from injury oleic acid-induced rat model ARDS. Seventeen male Sprague–Dawley rats were randomly assigned to 3 groups: Sham (n = 5), 6), + 6). The treatment groups injected...
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been widely used in high-risk acute myocardial infarction (AMI) patients with promising outcomes. However, the underlying molecular mechanisms remain unknown and a VA-ECMO animal model not yet established. The purpose of this study was to establish AMI rats evaluate long-term cardiac function.We first established 20 Sprague-Dawley (SD) by ligating left anterior descending coronary artery, while five underwent thoracotomy form...
Venovenous extracorporeal membrane oxygenation (VV ECMO) is now considered a reasonable option to salvage acute respiratory distress syndrome (ARDS). However, we lack rodent model for experimental studies. This study was undertaken establish an animal of VV ECMO in ARDS rats.A total 18 Sprague-Dawley (SD) rats (350 ± 50 g) were used this study. Using rat oleic acid (OA)-induced ARDS, established through cavoatrial cannulation the right jugular vein venous drainage and reinfusion with...
Myocardial ischemia/reperfusion injury (MI/RI) is a serious pathophysiological process relating to cardiovascular disease. Oroxin A (OA) natural flavonoid glycoside with various biological activities. However, its effect on the of MI/RI has not yet been reported. The aim this study was determine whether OA could alleviate induced inflammation and pyroptosis in vivo vitro, providing novel therapeutic regimen for treatment MI/RI. high-throughput drug screening strategy employed test 2,661...
Although venovenous extracorporeal membrane oxygenation (VV ECMO) is a reasonable salvage treatment for acute respiratory distress syndrome (ARDS), it requires sedating the patient. Sevoflurane and propofol have pulmonary protective immunomodulatory properties. This study aimed to compare effectiveness of sevoflurane on rats with induced ARDS undergoing VV ECMO.
Myocardial ischemia causes myocardial inflammation. Research indicates that the venoarterial extracorporeal membrane oxygenation (VA ECMO) provides cardiac support; however, inflammatory response caused by remains unresolved. Dexamethasone (Dex), a broad anti-inflammatory agent, exhibits cardioprotective effect. This study aims to investigate effect of Dex on rat model acute infarction (AMI) supported VA ECMO. Male Sprague-Dawley rats (300–350 g) were randomly divided into three groups: Sham...
The destruction of the pulmonary epithelial barrier in acute respiratory distress syndrome is caused by damage alveolar cells. Oroxin A an effective flavonoid component derived from medicinal plant Oroxylum indicum (L.) Kurz. In this study, oleic acid (OA)-induced A549 cell injury model was established vitro to explore protective mechanism A. experiment divided into following groups: control, OA and + group. OA-induced dose (time)-dependent detected CCK-8 assay. protein mRNA expression...
We describe in detail a novel surgical technique for repairing donor anterior left atrial wall defect vivo by rotating the posterior flap during lung transplantation. This method can safely and effectively address most common type of cuff defect: defect, with intact wall, typically retained when heart is also used. During anastomosis transplantation, excess trimmed into an flap. After completed, rotated 180° used as patch reconstruction anastomosis. restoring blood flow, flow rate pulmonary...
Abstract Background: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is now considered a reasonable option to salvage acute respiratory distress syndrome (ARDS). However, we lack rodent model for experimental studies. This study was undertaken establish an animal of VV-ECMO in ARDS rats.Methods: Fifteen Sprague-Dawley (SD) rats (350 ± 50 g) were used this study. Using rat oleic acid (OA)-induced ARDS, established through bi-caval cannulation the right jugular vein venous drainage...
Combined with Network Analysis (NA) and in vivo experimental methods, we explored verified the mechanism of Cepharanthine (CEP) involved treatment acute respiratory distress syndrome (ARDS). Potential targets CEP were searched using SwissTargetPrediction database. The pathogenic genes related to ARDS obtained DisGeNET A protein-protein interaction network common target disease-compound was subsequently built visualised. Functional enrichment analysis performed through Enrichr Finally, for...
Extracorporeal membrane oxygenation (ECMO) has been used as intraoperative hemodynamic support in patients with end-stage lung diseases and pulmonary hypertension undergoing transplantation (LT).The aim of this study was to identify the association artery pressure change during ECMO post-LT survival.The investigators collected analyzed data from Chinese Lung Transplantation Registry. Patients who have severe were enrolled. Post-LT mortality morbidity further compared.A total 208 recipients...
Abstract Background Acute respiratory distress syndrome (ARDS) is characterized by disruption of the alveolar–capillary barrier, resulting in severe alveolar edema and inflammation. D-tagatose (TAG) a low-calorie fructose isomer with diverse biological activities whose role ARDS has never been explored. We found that TAG protects lung tissues from injury oleic acid-induced rat model ARDS. Methods Seventeen male Sprague–Dawley rats were randomly assigned to 3 groups: Sham (n = 5), 6), + 6)....
Abstract Currently no proven effective treatment exists for lung ischemia-reperfusion injury (LIRI). Natural compounds represent a source of new drugs the different diseases. The present study aims to investigate Rebaudioside B (Reb B) as potential compound LIRI in vivo and vitro . includes human pulmonary alveolar cells line with epithelial type II A549 under oxygen-glucose deprivation/recovery (OGD/R) high-throughput cell viability screening identify most promising tested candidates....
Abstract Background: Although the effect of high intensity interval training (HIIT) was gradually explicit, little is explored about role and validity HIIT on patients following percutaneous coronary intervention (PCI). As far as we know, no evidence has been established to assess program for heart disease (CHD) attending cardiac rehabilitation after PCI. Therefore, this systematic review meta-analysis will be conducted efficacy safety CHD Methods: Seven electronic databases including Web...
Abstract Background: Acute respiratory distress syndrome (ARDS), a clinical resulting from intrapulmonary and/or extrapulmonary causes, is characterized by refractory hypoxemia. Currently, venovenous extracorporeal membrane oxygenation (VV ECMO) considered as reasonable alternative to salvage ARDS, but it requires sedation of the patient. Several studies suggest that anesthetics, such sevoflurane and propofol, have lung protective immunomodulatory functions. The aim this study was explore...