A5101620118- Circular RNAs in diseases
- MicroRNA in disease regulation
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- IL-33, ST2, and ILC Pathways
- Nerve injury and regeneration
- Diabetes Treatment and Management
- Neuroendocrine Tumor Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- RNA modifications and cancer
- Kawasaki Disease and Coronary Complications
- Autophagy in Disease and Therapy
- Advanced MRI Techniques and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Endoplasmic Reticulum Stress and Disease
Shanghai Ocean University
2024
Ministry of Agriculture and Rural Affairs
2024
Wuhan University of Technology
2024
Jianghan University
2024
Ningbo University
2014-2023
Anhui Medical University
2023
Central South University
2021-2023
Guizhou Normal University
2023
Sir Run Run Shaw Hospital
2022
Zhejiang University
2022
Contamination of foods and feeds by aflatoxins is a universal yet serious problem all over the world. Particularly, aflatoxin B1 (AFB1) most primary form readily leads to terrible damages human health. In this work, we construct sensitive aptasensor based on single-particle detection (SPD) analyze AFB1 in peanut samples with luminescence resonance energy transfer (LRET) between aptamer-modified upconversion nanoparticles (UCNPs-aptamer) gold (GNPs). The UCNP-aptamer plays as donor, while GNP...
In a clinical assay, enzymes are essential biomarkers for human disease diagnosis. this work, spectral-resolved single-particle detection (SPD) method is introduced to quantify alkaline phosphatase (ALP) activity in serum with supraparticle (SP) based on MnO2-modified gold nanoparticle (denoted as GNP@MnO2 SP) the probe. presence of ALP, 2-phospho-l-ascorbic acid trisodium salt can be hydrolyzed into l-ascorbic acid, which serves good reduction agent trigger decomposition MnO2 shell GNP...
Rapid quantification of permanganate (MnO4–) in aqueous solution with a convenient and sensitive single-particle-detection (SPD) method is demonstrated by dark-field optical microscopy. The design based on the selective etching Ag shell glucose-protected GNPs@Ag nanoparticle MnO4–. In presence MnO4–, noticeable red-shift localized surface-plasmon resonance (LSPR, from blue to green) together tremendous decrease extinction coefficient individual nanoparticles observed. MnO4– can then be...
Prostate cancer (PCa) is a leading cause of cancer-related death among males globally. To date, prostate-specific antigen (PSA), as typical tumour marker, has been widely used in the early diagnosis PCa. However, practical clinical tests, high serum levels PSA show probability for false-positive results, to misdiagnoses. In this study, we developed new classification system PCa, benign prostate hyperplasia (BPH) and healthy subjects by using surface-enhanced Raman scattering (SERS)-based...
Some recent studies have suggested that the use of dipeptidyl peptidase-4 inhibitors (DPP4i) is associated with cancer development. However, some other suggest no such association. The aim present study was to evaluate effect DPP4i on risk developing cancers. electronic databases PubMed, Medline, EMBASE, Web Science and Cochrane Library clinical trial registry were searched for published unpublished randomized trials humans. Eligible RCTs conducted in patients type 2 diabetes mellitus,...
An immunoassay protocol is described to detect tumor markers in human serum based on a sandwich structure consisting of nano-Si immune probes and SiC@Ag SERS-active substrate.
The aims of the study were to investigate prevalence pre-diabetes and explore its associated risk factors in rural areas Ningbo, China.A cross-sectional survey was conducted with 4583 adult residents China between March May 2013. used a multi-stage, stratified, cluster sampling method. Data collected included demographics medical history, anthropometric measurements, blood pressure, lipid, plasma glucose. After at least 10 h overnight fasting, participants underwent an oral glucose tolerance...
Ultrasensitive SERS-based immunoassay induced by SiO<sub>2</sub>@Au nanoprobe and hydrophilic–hydrophobic assembly substrate.
Diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC). Hyperglycemia, a chronic abnormality in diabetes, independent predictor cancer-associated mortality CRC. However, the underlying biological mechanism hyperglycemia CRC cells largely unknown. In present study, HCT-116 and HT-29 cell proliferation, apoptosis, migration invasion were assessed. addition, expression epithelial (E)-cadherin, vimentin high-mobility group A protein 2 (HMGA2) assessed using...
MicroRNAs (miRNAs) are potentially involved in the regulation of glucose and lipid metabolism. The aim this study was to investigate potential miRNA regulators for serum lipids blood gestational diabetes mellitus.Plasma samples were obtained from 53 women with GDM 46 normal pregnant women. Fasting a profile measured. Plasma expression profiles analyzed using microarray. To verify microarray data, miRNAs evaluated by real-time PCR. Gene ontology (GO) genes genomics (KEGG) pathway enrichment...
The nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation p65 is considered as mechanism for positive regulation NF-κB activity. According to our previous data, can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes import HCC progression. However, effect SUMO1-related SUMOylation on transcriptional activity relationship between phosphorylation remain obscure. Here, we...
Abstract High-fat diet (HFD) induced hepatic endoplasmic reticulum (ER) stress drives insulin resistance (IR) and steatosis. NK cells in adipose tissue play an important role the pathogenesis of IR obesity. Whether liver can induce ER thus promote obesity is still unknown. We demonstrate that HFD-fed mice display elevated production proinflammatory cytokine osteopontin (OPN) cells, especially CD49a+DX5– tissue-resident (trNK) cells. Obesity-induced stress, IR, steatosis are ameliorated by...
Type 2 diabetes mellitus (T2DM) increases the occurrence and mortality of liver cancer. Insulin growth factor (IGF) plays a crucial role in development cancer, specifically, IGF-1 may be involved cancer with preexisting T2DM. Autophagy contributes to cell survival apoptosis. However, relationship between autophagy has rarely been evaluated. The purpose this study was investigate whether promotes T2DM patients by promoting autophagy. Thirty-three hepatocellular carcinoma (HCC) 33 age-matched...
Hypertrophic cardiomyopathy (HCM) often requires repeated enhanced cardiac magnetic resonance (CMR) imaging to detect fibrosis. We aimed develop a practical model based on cine help identify patients with high risk of fibrosis and screen out without avoid unnecessary injection contrast.A total 273 HCM were divided into training test sets at ratio 7:3. Logistic regression analysis was used find predictive image features construct CMR model. Radiomic derived from the maximal wall thickness...
Background Kawasaki disease is a childhood systemic vasculitis that causes coronary artery abnormalities. The etiology remains unknown and there are no specific diagnostic tests. Circular non‐coding RNAs special class of endogenous display some characteristics an ideal biomarker. However, few studies have examined the expression circRNAs in serum (KD) patients. aim this study was to identify can serve as potential biomarkers for KD diagnosis. Methods cases were children diagnosed with (n =...