A5089699089- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Advanced Battery Technologies Research
- Heme Oxygenase-1 and Carbon Monoxide
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Aerogels and thermal insulation
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Sulfur Compounds in Biology
- Antimicrobial agents and applications
- MicroRNA in disease regulation
- Immune cells in cancer
- Medical and Biological Ozone Research
- Cell death mechanisms and regulation
- Atomic and Subatomic Physics Research
- Membrane Separation Technologies
- Porphyrin and Phthalocyanine Chemistry
- Graphene and Nanomaterials Applications
- Surface Modification and Superhydrophobicity
Anhui Medical University
2015-2025
Imaging Center
2024
Harbin Institute of Technology
2017-2022
Hefei University
2019-2020
First Affiliated Hospital of Anhui Medical University
2019
Bacterial infection poses a massive threat to our society, and bacterial biofilm is major cause of chronic recurrent infections. The treatment biofilms represents challenging task, the development antibacterial materials that can not only disperse but also kill bacteria increasing interest. Herein, we report fabrication well-defined nitric oxide (NO)-releasing amphiphiles, poly(ethylene oxide)-b-polyCouNO (PEO-b-PCouNO), where CouNO an N-nitrosoamine-based NO donor containing coumarin...
Hybrid capacitors, especially sodium-ion capacitors (SICs), which combine the complementary merits of high-energy batteries and high-power have received increasing research interest been expected to bridge gap between rechargeable EDLCs. The biggest challenge for SICs is overcome kinetics discrepancy sluggish faradaic anode rapid nonfaradaic capacitive cathode. To boost Na+ reaction kinetics, robust conductive Na2Ti2O5–x nanowire arrays constructed as an accessible affordable SIC anode. It...
It is of particular interest to develop new antibacterial agents with low risk drug resistance development and toxicity toward mammalian cells combat pathogen infections. Although gaseous signaling molecules (GSMs) such as nitric oxide (NO) formaldehyde (FA) have broad-spectrum performance the propensity development, many previous studies heavily focused on nanocarriers capable delivering only one GSM. Herein, we developed a micellar nanoparticle platform that can simultaneously deliver NO...
Chemotherapeutic drugs often fail to provide long-term efficacy due their lack of specificity and high toxicity. To enhance the biosafety reduce side effects these drugs, various nanocarrier delivery systems have been developed. In this study, we loaded anticancer drug doxorubicin (DOX) an MRI contrast agent into silica nanoparticles, coating them with pH-responsive tumor cell-targeting polymers. These polymers enable carrier achieve targeted controlled release in acidic environments. This...
Abstract Background While both CT-FFR and FAI are found to be associated with the development of CAD, their relationship hemodynamics plaque characteristics remains unclear. The present study aims investigate between assessed by combined in functionally significant coronary artery stenosis. Methods This retrospective included 130 patients suspected heart disease, who were admitted Department Cardiology our hospital underwent computed tomography angiography (CCTA) from January 2022 December...
The nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation p65 is considered as mechanism for positive regulation NF-κB activity. According to our previous data, can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes import HCC progression. However, effect SUMO1-related SUMOylation on transcriptional activity relationship between phosphorylation remain obscure. Here, we...
Theranostic platforms that combine therapeutic and imaging modalities have received increasing interest.
The emerging therapeutic potential of nitric oxide (NO) has spurred the rapid development NO donors to maximize outcomes. Although polymeric have shown extended release times and optimized biodistributions, many these macromolecular are non-degradable. Herein, we devise a donor by integrating photoresponsive N,N'-dinitroso-p-phenylenediamine (DNP) derivatives into middle block an amphiphilic triblock copolymer photo-mediated process transforms DNP quinondimine (QDI) moieties, enabling...
The aim of the present study was to examine apoptosis hepatocellular carcinoma cell line, HepG2, induced by treatment with folic acid-conjugated silica-coated gold nanorods (GNRs@SiO2-FA) in combination radiotherapy, and determine involvement apoptosis-related proteins. An MTT colorimetric assay used assess biocompatibility GNRs@SiO2-FA. distribution GNRs@SiO2-FA into cells observed using transmission electron microscopy (TEM). HepG2 cultured vitro were divided following 4 groups: i)the...
Abstract The ascending arousal system plays a crucial role in individuals' consciousness. Recently, advanced functional magnetic resonance imaging (fMRI) has made it possible to investigate the network (AAN) vivo. However, of AAN neuropathology human insomnia remains unclear. Our study aimed explore alterations and its connections with cortical networks chronic disorder (CID). Resting‐state fMRI data were acquired from 60 patients CID good sleeper controls (GSCs). Changes brain's...
Abstract To solve the issues of low ionic conductivity, poor interfacial stability, and weak mechanical strength in current polymer electrolytes, herein, UV curing method is proposed to in‐situ polymerize plastic crystal composite solid electrolyte (S‐PCCE). By using ethoxylated trimethylolpropane triacrylate (ETPTA) as polymerization monomer, conjunction with butadiene nitrile other additives, S‐PCCE prepared under ultraviolet light. The shows improved conductivity than materials. at room...
Multimodal collaborative therapy has been recognized as one of the more effective means to eliminate tumors in current biomedicine research field compared with monotherapy. Among them, by taking advantage its high-precision and controllability, phototherapy become a mainstay treatment. However, physical encapsulation free photosensitive units within nanocarriers was main implementations, which might inevitably result photosensitizer leakage side effect. For this purpose, kind multifunctional...
Tetraphenylethylene (TPE) moieties have been employed as a light-absorbing antenna for the activation of photoresponsive N -nitrosamine derivatives, enabling visible light-triggered NO release and efficient biofilm dispersal.
Chemotherapy is one of the most employed strategies in clinical treatment cancer, but low content drug molecules caused by inadequate accumulation carriers lesion locations has an adverse impact on therapeutic effect. To solve this issue, a kind high prodrug monomers with topological structures AB2 and AB3 were designed utilized to construct series polyprodrug amphiphiles, P[GMA(-l-RGD/-PEG)-CPTn] (n = 2 or 3), both targeting peptides (l-RGD) content. Depending structure monomers, could be...
In this contribution, a simple strategy was developed to fabricate high-fidelity and high-performance organic/inorganic composite aerogel by integrating dianhydrid-end capped polyamide acid (PAA) precursor multi-amino functionalized hydroxyapatite (m-AmHA; used as the inorganic cross-linkers) in different feed ratios. Followed freeze-drying thermal imidization treatments, chemical cross-linked polyimide (PI) HA based aerogels (HAx@PI, which x represents percentage of content) were obtained....
<title>Abstract</title> Chemotherapeutic drugs often fail to provide long-term efficacy due their lack of specificity and high toxicity. To enhance the biosafety reduce side effects these drugs, various nanocarrier delivery systems have been developed. In this study, we loaded anticancer drug doxorubicin (DOX) an MRI contrast agent into silica nanoparticles, coating them with pH-responsive tumor cell-targeting polymers. These polymers enable carrier achieve targeted controlled release in...
Breath-held electrocardiogram-gated cardiac cine imaging (ECG-CINE), as the gold standard for assessing function in magnetic resonance (MRI), is prone to motion artifacts. Conventional golden-angle (CGA) sampling has emerged a promising technique mitigating effects real-time imaging. However, ECG-CINE, irregular re-binning of radial k-space profiles based on CGA can exacerbate non-uniformity, resulting severe streaking The recently introduced segmented ratio (SGA) scheme aims solve this...