A5100454303- Inflammatory Bowel Disease
- Microscopic Colitis
- MicroRNA in disease regulation
- Eosinophilic Esophagitis
- Autophagy in Disease and Therapy
- Adenosine and Purinergic Signaling
- Autoimmune and Inflammatory Disorders
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Helicobacter pylori-related gastroenterology studies
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Neonatal Health and Biochemistry
- Fibroblast Growth Factor Research
- Folate and B Vitamins Research
- Extracellular vesicles in disease
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Vitamin D Research Studies
- COVID-19 and healthcare impacts
- Liver Diseases and Immunity
- Gastric Cancer Management and Outcomes
- Menstrual Health and Disorders
First Affiliated Hospital of Anhui Medical University
2024-2025
Anhui Medical University
2024-2025
Fudan University
2025
China Association of Acupuncture-Moxibustion
2025
Yangzhou University
2022-2024
Xiangya Hospital Central South University
2022
Central South University
2022
Jiangsu Province Hospital
2019-2021
Nanjing Medical University
2019-2021
Nanjing Brain Hospital
2020
Chemotherapeutic drugs often fail to provide long-term efficacy due their lack of specificity and high toxicity. To enhance the biosafety reduce side effects these drugs, various nanocarrier delivery systems have been developed. In this study, we loaded anticancer drug doxorubicin (DOX) an MRI contrast agent into silica nanoparticles, coating them with pH-responsive tumor cell-targeting polymers. These polymers enable carrier achieve targeted controlled release in acidic environments. This...
Excessive gonadotropin-releasing hormone (GnRH) is considered to be an initiating factor in the etiology of polycystic ovary syndrome (PCOS). GnRH neuronal axons terminate at hypothalamic arcuate nucleus and median eminence, where tanycytes, specialized glial cells, have been proposed modulate secretion through plasticity. However, precise role “GnRH-tanycyte unit” during pathological state PCOS has not thoroughly explored. In this study, we demonstrated architecture distribution neurons...
The associations between serum total bilirubin (sTB) levels, inflammatory marker and disease activity are not well understood in patients with bowel (IBD). present study investigated the association sTB levels IBD. We conducted a retrospective of 242 consecutive Crohn’s (CD) 211 ulcerative colitis (UC). Disease Activity Index (CDAI) score was used to assess CD Mayo UC. 255 clinically healthy subjects comprised control group, which come from same geographic area as IBD group. retrieved...
Mitochondrial damage contributes to extracellular matrix (ECM) deposition and renal fibrosis. In this study, we aimed (1) investigate whether fluorofenidone (AKF-PD) can attenuate mitochondrial in two fibrosis models: unilateral ureteral obstruction (UUO) ischemia-reperfusion injury (IRI), (2) explore the underlying mechanism. lesions were analyzed UUO IRI models. energy metabolism, biogenesis, oxidative stress measured assess effect of AKF-PD on addition, HK-2 cells stimulated with TGF-β...
Abstract Transmembrane-4 L-six family member-1 (TM4SF1) is a member of the L6 and functions as signal transducer to regulate tumor cell behaviors. However, function mechanism TM4SF1 in esophageal squamous carcinoma (ESCC) metastasis remains unclear. Here, we find that expression increased positively correlated with clinical TNM stage, N classification, differentiation, size, poor prognosis ESCC patients. Interestingly, demonstrate promotes adhesion, spreading, migration, invasion, but not...
Background High prevalence of vitamin D deficiency has been found among Crohn's disease (CD) patients. Vitamin probably participates in the pathogenesis CD, but this idea remains controversial. This study was to investigate levels CD patients and analyze relationship between intestinal inflammation.Methods were measured by chemiluminescence immunoassay 198 (96 active, 102 remission) 100 healthy controls. The correlation clinical parameters analysed. expression tight junction (TJ) proteins...
Food antigens have been shown to participate in the etiopathogenesis of inflammatory bowel disease (IBD), but their clinical value IBD is still unclear.To analyze levels specific immunoglobulin G (IgG) and E (IgE) antibodies against food patients determine pathogenesis IBD.We performed a retrospective study based on who visited First Affiliated Hospital Nanjing Medical University between August 2016 January 2018. A total 137 patients, including 40 with ulcerative colitis (UC) 97 Crohn's...
Some inflammatory bowel disease (IBD) patients in remission suffer from irritable syndrome (IBS)-like symptoms (IBD-IBS). The pathogenesis has not yet been elucidated. study aim is to evaluate relationships among quality of life (QOL), psychological status, and visceral sensitivity, explore the formation mechanism IBD-IBS.Forty-seven with Crohn's remission, 24 ulcerative colitis 26 IBS, 20 healthy controls were included study. abdominal pain, QOL, anxiety, depression evaluated through...
Mucosal healing has become the primary treatment target for patients with Crohn's disease (CD). We aimed to develop a noninvasive and convenient tool evaluate endoscopic activity in ileocolic CD.A retrospective multicenter study including 300 CD (training, 210 patients; test, 90 patients) was conducted at two tertiary referral centers. Independent risk factors associated were explored, which then combined into comprehensive index. The predictive performance evaluated area under receiver...
<title>Abstract</title> Chemotherapeutic drugs often fail to provide long-term efficacy due their lack of specificity and high toxicity. To enhance the biosafety reduce side effects these drugs, various nanocarrier delivery systems have been developed. In this study, we loaded anticancer drug doxorubicin (DOX) an MRI contrast agent into silica nanoparticles, coating them with pH-responsive tumor cell-targeting polymers. These polymers enable carrier achieve targeted controlled release in...
Background Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic first reported in Wuhan, China, several research on psychological impact patients with Crohn’s (CD) have been conducted. However, progression global and emergence SARS-CoV-2 B.1.617.2 (Delta) variant, follow-up studies need to be performed monitor alterations status health-related quality life (HRQoL) among CD patients. Aims We aimed evaluate Delta variant mental health population tried explore potent risk factors....
目的研究Crp家族转录调节因子fnrN突变对土壤杆菌ATCC 31749发酵性能和基因表达的影响。 方法利用三亲结合法将构建的自杀式质粒pJQ-fnrN-kan导入土壤杆菌ATCC 31749中，从而获得fnrN基因突变株(ΔfnrN)；分析ΔfnrN的发酵特性；基于RNA-Seq对产胶期土壤杆菌ATCC 31749野生菌和ΔfnrN差异表达基因进行分析。 结果fnrN的突变使土壤杆菌合成热凝胶能力下降了22.0%，转录组分析发现在ΔfnrN中186个基因表达发生显著性变化(|log2(|fold change|)|≥1且q≤0.001)，其中65%的基因表达上调。热凝胶合成的关键基因crdASC的表达受到不同程度的抑制，fnrN的突变使编码σ因子的ecfR和编码生物膜合成调节因子的sinR显著下调；ΔfnrN菌中与细胞色素有关基因cydAB、cy2、fixNOPQ的转录水平下调2−13倍。 结论fnrN通过调控ecfR和sinR的表达调控热凝胶合成，通过调控fixNOPQ等基因的表达参与氧信号调控，该研究有助于丰富对土壤杆菌氧调控系统的认识。