A5101531124- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- interferon and immune responses
- Chronic Kidney Disease and Diabetes
- Clostridium difficile and Clostridium perfringens research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Renal cell carcinoma treatment
- Healthcare professionals’ stress and burnout
- Bat Biology and Ecology Studies
- Long-Term Effects of COVID-19
- Metabolomics and Mass Spectrometry Studies
- Bacteriophages and microbial interactions
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Xiangya Hospital Central South University
2021-2024
Central South University
2020-2024
Dalian Medical University
2023-2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
Institute of Medical Biology
2018-2024
Third Hospital of Hebei Medical University
2023
Hebei Medical University
2023
Tianjin Medical University
2022
Shanxi Eye Hospital
2020-2022
Inflammatory response is closely associated with poor prognosis in elderly patients acute myocardial infarction (AMI). The aim of this study was to develop an easy-to-use predictive model based on medical history data at admission, systemic immune inflammatory index (SII), and (SIRI) predict the risk in-hospital mortality AMI.We enrolled 1550 AMI (aged ≥60 years) complete randomized them 5:5 training validation cohorts. Univariate multivariate logistic regression analyses were used screen...
Renal fibrosis is a common pathological outcome of various chronic kidney diseases, and as yet, there no specific treatment. Dapagliflozin has shown renal protection in some clinical trials glucose-lowering drug, but its role mechanism on remain unclear. In this study, we used 0.2% adenine diet-induced mouse model to investigate whether dapagliflozin could protect function alleviate animal model. vivo , found that dapagliflozin’s protective effect was associated with 1) sustaining...
Kokusaginine is an active ingredient alkaloid that has been isolated and extracted from Ruta graveolens L. Some researches have indicated alkaloids possess anti-inflammatory antioxidant effects. Nevertheless, the potential nephroprotective effects of kokusaginine on renal fibrosis remain undetermined. This study was conducted to examine protective effect explore underlying mechanisms using both in vivo vitro models. Renal induced male C57BL/6 J mice by feeding with 0.2% adenine-containing...
Mitochondrial damage contributes to extracellular matrix (ECM) deposition and renal fibrosis. In this study, we aimed (1) investigate whether fluorofenidone (AKF-PD) can attenuate mitochondrial in two fibrosis models: unilateral ureteral obstruction (UUO) ischemia-reperfusion injury (IRI), (2) explore the underlying mechanism. lesions were analyzed UUO IRI models. energy metabolism, biogenesis, oxidative stress measured assess effect of AKF-PD on addition, HK-2 cells stimulated with TGF-β...
Circular RNAs (circRNAs) are a novel type of non-coding RNA expressed across different species and tissues. At present, little is known about the expression function circRNAs in tree shrew brain. In this study, we used RNA-seq to identify 35,007 hippocampus cerebellum samples from infant (aged 47-52 days), young 15-18 months), old 78-86 months) shrews. We observed no significant changes total circRNA profiles brain regions over time. However, tended be downregulated Real-time RT-PCR analysis...
GTSE1 is well correlated with tumor progression; however, little known regarding its role in liver cancer prognosis. By analyzing the hepatocellular carcinoma (HCC) datasets GEO and TCGA databases, we showed that high expression of was advanced pathologic stage poor prognosis HCC patients. To investigate underlying molecular mechanism, generated knockdown cell line explored effects deficiency growth. Between wild-type cells, identified 979 differentially expressed genes (520 downregulated...
The tree shrew (Tupaia belangeri chinensis), a small animal widely distributed in Southeast Asia and southwest China, has the potential to be developed as an model for hepatitis C. To determine susceptibility of C virus (HCV) infection vitro vivo, well-established HCV, produced from J6/JFH1-Huh7.5.1 culture system, was used infect cultured primary tupaia hepatocytes (PTHs) shrews. results showed that HCV genomic RNA HCV-specific nonstructural protein 5A (NS5A) could detected PTH cell days...
Animal models of Zika virus (ZIKV) infection have recently been established in mice, guinea pigs, and nonhuman primates. Tree shrews (Tupaia belangeri) are an emerging experimental animal biomedical applications, but their susceptibility to ZIKV has not explored. In the present study, we show that subcutaneous inoculation led rapid viremia viral secretion saliva, as well typical dermatological manifestations characterized by massive diffuse skin rash on trunk. Global transcriptomic...
Idiopathic pulmonary fibrosis (IPF) is one of the most common and devastating interstitial lung diseases with poor prognosis. Currently, few effective drugs are available for IPF. Hence, we sought to explore role mefunidone (MFD), a newly synthesized drug developed by our team, in fibrosis. In this study, MFD was found attenuate bleomycin (BLM) -induced inflammation mice according Ashcroft alveolitis scoring. The protein contents total cell counts bronchoalveolar lavage fluids BLM-treated...
Idiopathic pulmonary fibrosis (IPF) is believed to be associated with a notable disruption of cellular energy metabolism. By detecting the changes metabolites in serum patients fibrosis, we aimed investigate diagnostic and prognostic value IPF, further elucidated mechanism their involvement fibrosis. Through metabolomics research, it was discovered that TCA cycle intermediates changed dramatically IPF patients. In another validation cohort 55 compared 19 healthy controls, found succinate, an...
Acute lung injury (ALI) is a severe disease that presents serious damage and excessive inflammation in lungs with high mortality without effective pharmacological therapy. Fluorofenidone (AKFPD) novel pyridone agent has anti-fibrosis, anti-inflammation, other activities, while the effect of fluorofenidone on ALI unclarified. Here, we elucidated protective effects underlying mechanism lipopolysaccharide (LPS)-induced ALI. In this study, alleviated tissue structure reduced mortality, decreased...
Breast cancer (BRCA) has become the most frequently appearing, lethal, and aggressive with increasing morbidity mortality. Previously, it was discovered that HAUS5 protein is involved in centrosome integrity, spindle assembly, completion of cytoplasmic division process during mitosis. By encouraging chromosome misdivision aneuploidy, potential to cause cancer. The significance BRCA relationship between its expression clinical outcomes or immune infiltration remains unclear.Pan-cancer...
Background: Addictive stimulant drugs, such as methamphetamine (METH), increase the risk of exposure to human immunodeficiency virus-1 (HIV-1) infection and thus predispose individuals development HIV-associated neurocognitive disorders (HANDs). Previous studies have indicated that HIV-Tat (the transactivator transcription) METH can synergistically induce autophagy in SH-SY5Y neuroblastoma cells plays a pivotal role neuronal dysfunction HANDs. However, underlying mechanism METH-and...
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes (T2DM). Carotid intima-media thickness (CIMT) considered a preclinical stage atherosclerosis. Therefore, it necessary to identify related risk factors for CIMT facilitate early prevention CVD. Previous studies have shown that visceral fat area (VFA) factor T2DM However, few focused on effects VFA associated T2DM. Moreover, considering body distribution shows regional racial...
Background: Breast cancer (BRCA) is the most common type of among women worldwide. MiR-1260b has been widely demonstrated to participate in multiple crucial biological functions tumorigenesis, but its functional effect and mechanism human breast have not fully understood. Methods: qRT-PCR was used detect miR-1260b expression 29 pairs tissues normal adjacent tissues. Besides, level BRCA cells also further validated by qRT-PCR. played role prognostic process using Kaplan-Meier curves. In...
To identify the common and specific molecular mechanisms of three well-defined subtypes endometriosis (EMs): ovarian (OE), peritoneal (PE), deep infiltrating (DIE).Four microarray datasets: GSE7305 GSE7307 for OE, E-MTAB-694 PE, GSE25628 DIE were downloaded from public databases conducted to compare ectopic lesions (EC) with eutopic endometrium (EU) EMs patients. Differentially expressed genes (DEGs) identified by limma package divided into two parts: DEGs among in each subtype, both which...
Tree shrew is a novel laboratory animal with specific characters for human disease researches in recent years. However, little known about its characteristics of gut microbial community and intestinal commensal bacteria. In this study, 16S rRNA sequencing method was used to illustrate the microbiota structure Enterobacteriaceae bacteria were isolated demonstrate their features. The results showed Epsilonbacteraeota (30%), Proteobacteria (25%), Firmicutes (19%), Fusobacteria (13%),...
BACKGROUND:Retinoblastoma (RB) seriously endangers the vision and even life of patients. This study aimed to explore endoplasmic reticulum stress (ERS) drug resistance RB verify effect miR-512-3p as a regulator XBP-1 shearing mechanism on ERS, proliferation, apoptosis, autophagy levels cells. MATERIAL AND METHODS:Y79, weri-RB1, HXO-RB44 cells were treated with cisplatin (DDP) gradient concentration construct DDP-resistant The inhibition rate cell proliferation assessed by CCK-8 assay....