A5006718933- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Cancer-related molecular mechanisms research
- Prostate Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Neurogenetic and Muscular Disorders Research
- Acupuncture Treatment Research Studies
- Extracellular vesicles in disease
- Alkaline Phosphatase Research Studies
- Calcium Carbonate Crystallization and Inhibition
- Genetic and Kidney Cyst Diseases
- Occupational and environmental lung diseases
- Infective Endocarditis Diagnosis and Management
- MicroRNA in disease regulation
Third Xiangya Hospital
2021-2024
Central South University
2020-2024
Huadong Hospital
2022
Fudan University
1998-2022
Wuxi People's Hospital
2014-2022
Nanjing Medical University
2014-2022
AbbVie (United States)
2020
Xiangya Hospital Central South University
2020
Zhongshan Hospital
2013
Individuals with inactive pulmonary tuberculosis (PTB) lesions were found to be high-risk populations for active PTB development. This retrospective study evaluated the association between different types of and development aiming provide epidemiological evidence developing precise intervention strategies. Based on a population-based case-finding project conducted elderly, total 154 028 subjects who had participated in 2020 baseline survey was included current analysis. During 2-year...
Idiopathic pulmonary fibrosis (IPF) is one of the most common and devastating interstitial lung diseases with poor prognosis. Currently, few effective drugs are available for IPF. Hence, we sought to explore role mefunidone (MFD), a newly synthesized drug developed by our team, in fibrosis. In this study, MFD was found attenuate bleomycin (BLM) -induced inflammation mice according Ashcroft alveolitis scoring. The protein contents total cell counts bronchoalveolar lavage fluids BLM-treated...
Idiopathic pulmonary fibrosis (IPF) is believed to be associated with a notable disruption of cellular energy metabolism. By detecting the changes metabolites in serum patients fibrosis, we aimed investigate diagnostic and prognostic value IPF, further elucidated mechanism their involvement fibrosis. Through metabolomics research, it was discovered that TCA cycle intermediates changed dramatically IPF patients. In another validation cohort 55 compared 19 healthy controls, found succinate, an...
Acute lung injury (ALI) is a severe disease that presents serious damage and excessive inflammation in lungs with high mortality without effective pharmacological therapy. Fluorofenidone (AKFPD) novel pyridone agent has anti-fibrosis, anti-inflammation, other activities, while the effect of fluorofenidone on ALI unclarified. Here, we elucidated protective effects underlying mechanism lipopolysaccharide (LPS)-induced ALI. In this study, alleviated tissue structure reduced mortality, decreased...
Bladder cancer is the second-most common malignancy in urogenital system and most men. However, our understanding of driving mechanisms bladder remains incomplete. The forkhead box (FOX) family transcription factors implicated development malignancies. Many exosomal microRNAs have been identified as regulators mediators expression FOX, including FOXC1. miR-4792 has known a tumor miRNA suppressor. function miR-4792/FOXC1 signaling unknown. Here, we studied role by using multiple cell lines...
The incidence rate of prostate cancer is increasing rapidly. This study aims to explore the gene-associated mechanism biochemical recurrence (BCR) after radical prostatectomy and construct a prognostic model.The DEseq2 R package was used for differential expression mRNA. ClusterProfiler analyze functional enrichment Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) related mechanisms. Survival, Survminer, My.stepwise packages were model predict recurrence-free probability. RMS draw...
Abstract Background To determine the prostate cancer biochemical recurrence‐related fusion biopsy characteristics before radical surgery and to establish risk prediction model of recurrence cancer. Methods Three hundred four patients undergoing for at Huadong Hospital affiliated Fudan University between 2009 2020 preoperative magnetic resonance imaging (MRI) with suspicious lesions. Each case was followed by a 10 + x needle combination targeted (intentional or robotic fusion) systematic...
Acute lung injury (ALI) is a life-threatening disease which has high mortality and lacks effective pharmacological treatments. Excessive inflammation oxidative stress are the key pathogenesis of ALI. Mefunidone (MFD), novel small molecule compound, displayed anti-inflammation anti-oxidative effects on streptozocin (STZ) db/db mice in our previous studies. In this study, we aimed to investigate MFD lipopolysaccharide (LPS)-induced ALI explore potential molecular mechanisms.We investigated...
Lung cancer (LC) is a prevailing primary tumor in the lung. lncRNA non-coding RNA activated by DNA damage (NORAD) popular target human cancers. This experiment designed to probe mechanism of LC progression. NORAD expression normal lung epithelial cells and was examined then silenced assess its effect on cell proliferation, invasion, migration. Subcellular localization analyzed through online databases corroborated fractionation nuclear cytoplasmic assay. The binding relations between...
Abstract Thirteen different wild species of the genus Oryza were investigated for their response to anther culture and plant regeneration. Callus induction from microspores anthers was found be strongly dependent on species. Although large numbers species, including O. barthii, latifolia, australiensis, minuta, nivara, paraguagensis eichingeri , cultured, no calli could obtained. However, produced punctata, perennis, alta, ridleyi rufipogon although frequency callus different. Similar...
Germline mutations play an important role in the pathogenesis of lung cancer. Nonetheless, research on malignant ground glass opacity (GGO) nodules is limited.A total 13 participants with GGO were recruited this study. Peripheral blood was used for exome sequencing, and germline analyzed using InterVar. The whole sequencing dataset a filtering strategy. KOBAS 3.0 to analyze KEGG pathway further identify possible deleterious mutations.There seven potentially mutations. NM_001184790:exon8:...
Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder that affects the structure and function of motile cilia, leading to classic clinical phenotypes, such as situs inversus, chronic sinusitis, bronchiectasis, repeated pneumonia infertility. In this study, we diagnosed female patient with PCD who was born in consanguineous family through manifestations, transmission electron microscopy immunofluorescence staining. A novel DNAAF4 variant NM_130810: c.1118G>A (p. G373E)...
Objective To explore the protective effect of Salvianolic acid B on isolated lung in rats.Method Twenty-four SD rats were randomly divided into 2 groups:control group and experimental (n =12 each).The control was perfused with raffinose-low potassium dextran (R-LPD),and that R-LPD 800 mg/L B.The model established all these rats.Wet/dry weight ratio (W/D),myeloperoxidase (MPO),malondialdehyde (MDA) superoxide dismutase (SOD) measured,and pulmonary structures observed by HE staining at...