A5101889149- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Reproductive Biology and Fertility
- Conducting polymers and applications
- Peripheral Neuropathies and Disorders
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Peroxisome Proliferator-Activated Receptors
- Ovarian function and disorders
- Metabolism, Diabetes, and Cancer
- Cancer Diagnosis and Treatment
- Computational Drug Discovery Methods
- Retinal Diseases and Treatments
- Immunotoxicology and immune responses
- Autoimmune Neurological Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Metabolomics and Mass Spectrometry Studies
- COVID-19 and healthcare impacts
- Gender Studies in Language
- Retinal and Optic Conditions
- Head and Neck Cancer Studies
- Drug-Induced Adverse Reactions
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2025
Sun Yat-sen University
2023
Sun Yat-sen Memorial Hospital
2023
Peking Union Medical College Hospital
2020
Institute of Medical Biology
2018
Institut de Recherche Vaccinale
2013
Enterovirus 71 (EV-A71) and Coxsackievirus A16 (CV-A16) are the two most common pathogens causing hand, foot, mouth disease (HFMD). Previously, we obtained one candidate live attenuated strain each for EV-A71 CV-A16; here, evaluated safety immunogenicity of a combinedlive vaccine against CV-A16 generated from these strains. Rhesus monkeys were intramuscularly treated with combinationvaccine both or either alone. No fever atypical clinical signs observed in any animals. Monkeys vaccinated...
Background: The safety of novel vaccines against COVID-19 is currently a major focus preclinical research. As part the evaluation testing package, 24 healthy guinea pigs were used to determine whether repeated administration inactivated SARS-CoV-2 vaccine could induce active systemic anaphylaxis (ASA), and evaluate its degree severity.Method: According sex body weight, animals randomly divided into three experimental groups (eight per group). negative control group received 0.9% sodium...
Hand, foot and mouth disease is a common acute viral infectious that poses serious threat to the life health of young children. With development an effective inactivated EV71 vaccine, CA16 has become main pathogen causing HFMD. Effective safe vaccines against this are urgently needed. In our previous study, bivalent vaccine was shown have good immunogenicity induce neutralizing antibodies in mice monkeys. Repeated administration toxicity critical safety test preclinical evaluation vaccines....
Coxsackievirus A16 (CV-A16) is a major causative pathogen of hand, foot, and mouth diseases (HFMDs). The licensed HFMD vaccine targets EV-A71 without cross-protection against CV-A16. Thus, CV-A16 needed. In this study, the immunogenicity protective efficacy live attenuated candidate, K168-8Ac, were evaluated in rhesus monkey model. Four passages strain (P35, P50, P60, P70) administered to monkeys, its effect was identified. immunized monkeys clinically asymptomatic, except for slight fever....
Mature oocytes at the metaphase II status (MII-stage oocytes) played an important role in assisted reproductive technology non-human primates.In order to improve proportion of MII-stage retrieval, three different superovulation protocols were performed on 24 female cynomolgus monkeys.All monkeys received once-daily injection follicle-stimulating hormone (25 international unit [IU]) day 3 menstruation, 3-day intervals, twice daily for 8-12 days until time human chorionic gonadotropin (1,500...
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that severely affects human health, but the pathogenesis of disease remains unknown. The high-fat/high-sucrose diets combined with streptozotocin- (STZ-) induced nonhuman primate animal model are valuable research source T2DM. Here, we present study STZ rhesus macaque T2DM utilizes quantitative iTRAQ-based proteomic method. We compared protein profiles in liver STZ-treated macaques as well age-matched healthy controls. identified 171...
ABSTRACT The use of cynomolgus monkeys ( Macaca fascicularis ) has facilitated the establishment gene-modified animal models, and appropriate number high-quality mature oocytes (MII-stage oocytes) are crucial in assisted reproductive technologies (ART) macaques. In this study we performed 3 different superovulation protocols on 24 female aimed to improve proportion MII-stage oocyte retrieval. results suggested some differences between personalized protocol I II. Afterwards, Intracytoplasmic...
Objective: To explore the characteristics of psychiatric symptoms and caregivers' distress in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Methods: Seventy-two patients with anti-NMDAR encephalitis were investigated Peking Union Medical College Hospital from 2011 to 2018. The Chinese version Neuropsychiatric Inventory-Questionnaire (NPI-Q) was used assess severity neuropsychiatric around treatment. Results: A highly positive correlation existed between scores caregiver distress,...