A5108059048- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Nuclear Receptors and Signaling
- Bladder and Urothelial Cancer Treatments
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Antibiotic Resistance in Bacteria
- Alzheimer's disease research and treatments
- Cancer Immunotherapy and Biomarkers
- Antibiotics Pharmacokinetics and Efficacy
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- Animal Virus Infections Studies
- Ferroptosis and cancer prognosis
- Nerve injury and regeneration
- Neurological disorders and treatments
- Immune cells in cancer
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Colorectal Cancer Treatments and Studies
- Viral gastroenteritis research and epidemiology
- RNA regulation and disease
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Peking Union Medical College Hospital
2011-2024
Henan University of Science and Technology
2022-2024
Suzhou Institute of Systems Medicine
2021-2024
Shenzhen Weiguang Biological Products (China)
2023-2024
State Key Laboratory of Medicinal Chemical Biology
2016-2023
Southeast University
2022-2023
Nankai University
2016-2023
Northwest Normal University
2023
Shangqiu Normal University
2022
Autophagy requires diverse membrane sources and involves trafficking of mATG9, the only protein in ATG family. However, molecular regulation mATG9 for autophagy initiation remains unclear. Here we identified two conserved classic adaptor sorting signals within cytosolic N-terminus which mediate from plasma trans-Golgi network (TGN) via interaction with AP1/2 complex. Src phosphorylates at Tyr8 to maintain its endocytic constitutive unstressed conditions. In response starvation,...
The accumulation of acidic metabolic waste products within the tumor microenvironment inhibits effector functions tumor-infiltrating lymphocytes (TILs). However, it remains unclear how an environment affects T cell metabolism and differentiation. Here we show that prolonged exposure to acid reprograms intracellular mitochondrial fitness preserves stemness. Mechanistically, elevated extracellular acidosis impairs methionine uptake via downregulation SLC7A5, therefore altering H3K27me3...
Abstract Cancer cells develop multiple strategies to evade T cell-mediated killing. On one hand, cancer may preferentially rely on certain amino acids for rapid growth and metastasis. the other sufficient nutrient availability uptake are necessary mounting an effective cell anti-tumor response in tumor microenvironment (TME). Here we demonstrate that outcompete cystine due high Slc7a11 expression. This competition induces T-cell exhaustion ferroptosis, characterized by diminished memory...
Mitophagy is a fundamental process that determines mitochondrial quality and homeostasis. Several mitophagy receptors, including the newly identified FUNDC1, mediate selective removal of damaged or superfluous mitochondria through their specific interaction with LC3. However, precise mechanism by which this regulated to initiate not understood. Here, we report solution structure LC3 in complex peptide containing FUNDC1 LC3-interacting region (LIR) motif. The reveals noncanonical LC3-LIR...
Growing cases of patients reported have shown a potential relationship between (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 infection and Parkinson's disease (PD). However, it is unclear whether there molecular link these two diseases. Alpha-synuclein (α-Syn), an aggregation-prone protein, considered crucial factor in PD pathology. In this study, bioinformatics analysis confirmed favorable binding affinity α-Syn spike (S) protein nucleocapsid (N) direct interactions were...
Abstract The interactions between tumor cells with their microenvironments, including hypoxia, acidosis and immune cells, lead to the heterogeneity which promotes progression. Here, we show that SIAH2-NRF1 axis remodels microenvironment through regulating mitochondrial function, tumor-associated macrophages (TAMs) polarization cell death for maintenance Mechanistically, low gene expression in breast cancers is associated a poor clinical outcome. hypoxia-activated E3 ligase SIAH2 spatially...
Abstract Background We evaluated an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine for immunogenicity and safety in adults aged 18–59 years. Methods In this randomized, double-blinded, controlled trial, healthy received a medium dose (MD) or high (HD) of the at interval either 14 days 28 days. Neutralizing antibody (NAb) anti-S anti-N antibodies were detected different times, adverse reactions monitored after full immunization. Results A total 742 enrolled...
Despite recent success in using the invariance principle for out-of-distribution (OOD) generalization on Euclidean data (e.g., images), studies graph are still limited. Different from images, complex nature of graphs poses unique challenges to adopting principle. In particular, distribution shifts can appear a variety forms such as attributes and structures, making it difficult identify invariance. Moreover, domain or environment partitions, which often required by OOD methods data, could be...
Abstract Improved vaccination requires better delivery of antigens and activation the natural immune response. Here we report a lipid nanoparticle system with capacity to carry antigens, including mRNA proteins, which is formed into virus-like structure by surface decoration spike demonstrating application against SARS-CoV-2 variants. The strategy uses S1 protein from Omicron BA.1 on deliver XBB.1. particle enables specific augmentation mRNAs expressed in human respiratory epithelial cells...
The pharmacokinetics and tissue distribution of enrofloxacin were determined in Yellow River carp (Cyprinus carpio haematopterus) reared at 20°C after single oral administration 10 mg·kg-1 body weight (BW). Plasma, bile, different samples, including liver, kidney, gill, gut, skin-muscle, collected predetermined times points. An HPLC method was developed to simultaneously determine the concentrations its metabolite, ciprofloxacin. However, ciprofloxacin only detectable some liver samples with...
Recently Graph Injection Attack (GIA) emerges as a practical attack scenario on Neural Networks (GNNs), where the adversary can merely inject few malicious nodes instead of modifying existing or edges, i.e., Modification (GMA). Although GIA has achieved promising results, little is known about why it successful and whether there any pitfall behind success. To understand power GIA, we compare with GMA find that be provably more harmful than due to its relatively high flexibility. However,...
The constant mutation of SARS-CoV-2 has led to the continuous appearance viral variants and their pandemics improved development vaccines with a broad spectrum antigens curb spread virus. work described here suggested novel vaccine virus-like structure (VLS) composed combined mRNA protein that is capable stimulating immune system in manner similar infection. This VLS characterized by its ability specifically target dendritic cells and/or macrophages through S1 recognition DC-SIGN receptor...