A5100334297- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Ammonia Synthesis and Nitrogen Reduction
- Nanomaterials for catalytic reactions
- Viral gastroenteritis research and epidemiology
- Biodiesel Production and Applications
- Advanced Combustion Engine Technologies
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Catalytic Processes in Materials Science
- Viral Infections and Vectors
- Disaster Response and Management
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Retinal Diseases and Treatments
- SARS-CoV-2 detection and testing
- Advanced Image Processing Techniques
- Advanced battery technologies research
- Immunodeficiency and Autoimmune Disorders
- Rabies epidemiology and control
- Bacterial biofilms and quorum sensing
- Animal Virus Infections Studies
Yunnan Center for Disease Control And Prevention
2009-2024
Donghua University
2005-2024
Hunan Provincial Center for Disease Control and Prevention
2023
Sichuan University of Science and Engineering
2016-2023
China University of Petroleum, Beijing
2022
East China Normal University
2021
Shanghai Tenth People's Hospital
2011-2019
Tongji University
2011-2019
Sun Yat-sen University
2015-2017
Sun Yat-sen Memorial Hospital
2015-2017
Abstract Background We evaluated an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine for immunogenicity and safety in adults aged 18–59 years. Methods In this randomized, double-blinded, controlled trial, healthy received a medium dose (MD) or high (HD) of the at interval either 14 days 28 days. Neutralizing antibody (NAb) anti-S anti-N antibodies were detected different times, adverse reactions monitored after full immunization. Results A total 742 enrolled...
Effectiveness of heterologous booster regimes with ad5 vectored COVID-19 vaccine in a large, diverse population during the national-scale outbreak SARS-CoV-2 omicron predominance China has not been reported, yet. We conducted large-scale cohort-control study six provinces China, and did retrospective survey on attack risk this outbreak. Participant aged ≥18 years five previous trials who were primed 1 to 3 doses ICV received either intramuscular or orally inhaled included heterologous-trial...
To determine the ability of anterior segment optical coherence tomography (AS-OCT) in measuring distance from corneoscleral limbus to insertion site horizontal extraocular muscles adult patients with strabismus.A total 16 strabismus were recruited for this study. The limbus-insertion distances rectus measured AS-OCT preoperatively and calipers intraoperatively. intraclass correlation coefficient (ICC), Pearson's coefficients, Bland-Altman plots used evaluate degree agreement between two...
The pathogenic potential and commensal nature of Staphylococcus aureus allows for easy transmission both within outside the hospital environment, nasal carriage may be responsible some serious infections. This study aimed to determine molecular epidemiological characteristics colonization by S. in community residents (CR) healthcare workers (HW) at Sun Yat-Sen University, Guangzhou, China.A total 589 volunteers, CR (n = 297) HW 292), were recruited. Each subject completed a questionnaire,...
Since March 2014, the Ebola Virus Disease (EVD) outbreak in West Africa disrupted health care systems - especially Guinea, Liberia and Sierra Leone with a consequential stress on area's routine immunization programs. To address perceived decreased vaccination coverage, conducted catch-up campaign during 24-27 April 2015. We coverage survey report estimates surrounding time of EVD campaign.We selected 3 villages from each communities obtained dates birth measles vaccine (MV) 3rd dose...
To characterize the vascular changes in eyes within acute phase of retinal arterial occlusion (RAO) by optical coherence tomography angiography (OCT-A) imaging. This was a retrospective, observational study. Nineteen patients with RAO (symptom onset 7 days) and 19 age sex-matched normal control individuals were included. A comprehensive ophthalmic examination OCT-A conducted for all patients. The vessel density superficial capillary plexus (SCP), deep (DCP), area width 300 μm around FAZ...
ObjectivesTo evaluate the immunogenicity and safety of an anti-rabies monoclonal antibody (mAb), ormutivimab, compared with human rabies immunoglobulin (HRIG).MethodsThis phase III trial was designed as a randomized, double-blind, non-inferiority clinical in patients aged ≥18 years suspected World Health Organization category Ⅲ exposure. The participants were randomized 1:1 to ormutivimab HRIG groups. After thorough wound washing injection ormutivimab/HRIG on day 0, vaccination administered...
The Ebola virus disease spread rapidly in West Africa 2014, leading to the loss of thousands lives. Community engagement was one key strategies interrupt transmission, and practical community level measures needed be explored field tailored specific context communities.First, community-level education on (EVD) prevention launched for community's social mobilizers six districts Sierra Leone beginning November 2014. Then, from January May 2015, three pilot communities, local trained members...
Abstract Background Several COVID-19 vaccines are in widespread use China. Few data exist on comparative immunogenicity of different given as booster doses. We aimed to assess neutralizing antibody levels raised by injectable and inhaled aerosolized recombinant adenovirus type 5 (Ad5)-vectored vaccine a heterologous after an inactivated two-dose primary series. Methods Using open-label prospective cohort design, we recruited 136 individuals who had received series followed either or...
Heterologous vaccine schedules have been recommended to provide superior immunity and protection against emergent SARS-CoV-2 variants of concern. We aimed evaluate the safety, immunogenicity, efficacy an mRNA COVID-19 RQ3013 compared with adenoviral vectored Ad5-nCoV protein subunit ZF2001 as fourth dose in adults primed three doses inactivated vaccines China.
Selective hydrogenation of halogenated nitrobenzenes (XNBs) to amines (XANs) is great importance for practical applications. Non-noble metal-based catalysts have shown prominent advantages in price and reserves accompanying low activity selectivity toward the even under harsh conditions. In this work, inexpensive Ni–Co-based composites (NxCC) were prepared situ tandem XNBs XANs by using hydrogen released from ammonia borane (AB) hydrolysis ambient pressure. The results show these NxCC...
As a recently launched novel vaccine used as one of the vaccines for final eradication polios worldwide, complete data on consistency and immunogenicity characteristics inactivated poliomyelitis made from Sabin strain (sIPV) its safety in large-scale populations are required to support future use this worldwide. A phase IV clinical trial was conducted perform an evaluation lot-to-lot three commercial batches sIPV 1200 infants investigate vaccine's 20,019 active monitoring 29,683 passive...
Abstract Manual heart disease diagnosis with the electrocardiogram (ECG) is intractable due to intertwined signal features and lengthy procedure, especially for 24-hour dynamic ECG signals. Consequently, even experienced cardiologists may face difficulty in producing all accurate reports. In recent years, neural network-based automatic methods have exhibited promising performance, suggesting a potential alternative labor-intensive examination conducted by cardiologists. However, many...
BackgroundChina's three inactivated enterovirus A71 (EV-A71) vaccines are the first and currently world's only EV-A71 approved by a national regulatory authority used to prevent associated diseases. The vary vaccine strain, manufacturing cell substrate, antigen dose, but no head-to-head comparisons of these have been done. We compared immunogenicity in children 6-35 months old.MethodsWe recruited healthy aged who lived study site county into multicentre, open-label, non-inferiority,...
The Sabin-strain-based inactivated poliovirus vaccine (sIPV) plays an important role in poliomyelitis eradication developing countries. As part of the phase III clinical development program, this study aimed to evaluate safety, immunogenicity and lot-to-lot consistency sIPV 2-month-old infants.We conducted a III, randomized, double-blind, positive-controlled trial which 1300 healthy infants were randomly assigned four groups 1:1:1:1 ratio receive one three lots or control IPV at 2, 3 4...