A5086038216- Urinary Bladder and Prostate Research
- Cancer-related gene regulation
- Brucella: diagnosis, epidemiology, treatment
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pelvic floor disorders treatments
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Salmonella and Campylobacter epidemiology
- Spinal Dysraphism and Malformations
- COVID-19 epidemiological studies
- PI3K/AKT/mTOR signaling in cancer
- Viral-associated cancers and disorders
- Orthopedic Surgery and Rehabilitation
- Urinary and Genital Oncology Studies
- Biochemical and Molecular Research
- Bacteriophages and microbial interactions
- Tendon Structure and Treatment
- Cancer Mechanisms and Therapy
- Sexual function and dysfunction studies
- Burn Injury Management and Outcomes
First Affiliated Hospital of Nanchang University
2018-2024
Nanchang University
2018-2024
Guangdong Provincial People's Hospital
2022
Guangdong Academy of Medical Sciences
2022
Chinese Center For Disease Control and Prevention
2019-2021
Center for Disease Control
2019-2021
Sun Yat-sen Memorial Hospital
2017-2019
Sun Yat-sen University
2017-2019
Tangshan People's Hospital
2019
Weifang Medical University
2019
Protein arginine methyltransferases (PRMT) catalyze protein methylation and play an important role in many biological processes. Aberrant PRMT expression tumor cells has been documented several common cancer types; however, its precise contribution to hepatocellular carcinoma (HCC) cell invasion metastasis is not fully understood. In this study, we identified a new oncogene, PRMT9, whose overexpression strongly promotes HCC metastasis. PRMT9 was detected more frequently tissues than adjacent...
Long noncoding RNAs (lncRNAs) are involved in a variety of biological processes such as tumor proliferation and metastasis. A close relationship between hepatitis B virus X protein (HBx) SMYD3 promoting the metastasis hepatocellular carcinoma (HCC) was recently reported. However, exact oncogenic mechanism HBx-SMYD3 remains unknown. In this study, by performing lncRNA microarray analysis, we identified novel that regulated both HBx SMYD3, named it lncIHS (lncRNA intersection microarray)....
Both lysine and arginine methyltransferases are thought to be promising therapeutic targets for malignant tumors, yet how these function in especially hepatocellular carcinoma (HCC), has not been fully elucidated. Here, we reported that SMYD4, a methyltransferase, acts as an oncogene HCC. SMYD4 was highly upregulated HCC promoted cell proliferation metastasis. Mechanistically, PRMT5, well-known identified SMYD4-binding protein. monomethylated PRMT5 enhanced the interaction between MEP50,...
Abstract Increasing evidence suggests that PRMT 5, a protein arginine methyltransferase, has roles in cell growth regulation and cancer development. However, the role of 5 hepatocellular carcinoma ( HCC ) progression remains unclear. Here, we showed expression was frequently upregulated tissues, its inversely correlated with overall survival patients. knockdown markedly inhibited vitro proliferation vivo tumorigenesis. We revealed mechanism 5‐induced partially mediated by BTG downregulation,...
Uridine-cytidine kinase 2 (Uck2) has been demonstrated to activate antitumor prodrugs and regulate chemosensitivity in cancer cells. However, the expression function of Uck2 hepatocellular carcinoma (HCC) remain unknown. In this study, we were first systematically elucidate role HCC.Uck2 gene was queried between normal liver tissues HCC a web-based data mining platform (www.oncomine.org). tissue microarray determined by immunohistochemical staining. The clinical prognostic significance...
BACKGROUND: Tumor metastasis is the major reason for poor prognosis of hepatocellular carcinoma (HCC) patients after hepatic resection. SMYD3 has been demonstrated to promote liver tumor in mice. However, detailed molecular mechanism still largely unknown.The effect on invasiveness and HCC was analyzed by immunohistochemistry, migration assay, invasion wound healing assay vivo lung assay. Mass spectrometry analysis conducted using proteins pulled down H3K4me3 antibody SMYD3-overexpressing...
The Ebola virus disease spread rapidly in West Africa 2014, leading to the loss of thousands lives. Community engagement was one key strategies interrupt transmission, and practical community level measures needed be explored field tailored specific context communities.First, community-level education on (EVD) prevention launched for community's social mobilizers six districts Sierra Leone beginning November 2014. Then, from January May 2015, three pilot communities, local trained members...
We studied the efficacy of culture-specific antibiotic therapy for chronic bacterial prostatitis (CBP) patients with or without prostatic calculi.This study included 101 (21-62 years old) who met consensus criteria CBP (National Institutes Health category II).According to results transrectal ultrasonography (TRUS), all were divided into two groups: Group 1, calculi, n539; 2, n562.All received optimal antimicrobial 4 weeks and followed up a minimum 3 months (range: 3-8 months).In addition...
Abstract Background: At present, as a serious zoonotic infectious disease, the incidence of brucellosis is increasing each year worldwide, exhibiting signs resurgence. Brucellosis seriously threatens health humans, and it necessary to strengthen methods utilized for its rapid accurate diagnosis. Methods: Bioinformatic technology was used predict B-cell epitopes main outer membrane proteins Brucella subsequently verified antigenicity these epitopes. Prepared multiepitope fusion protein by...
Walker, R.; Cibrik, D. M.; Tedesco-Silva, H.; Johnston, T.; Kim, Y. S.; Zibari, G.; Cornu-Artis, C.; Panis, Jiang, H. Author Information
To evaluate the biomechanical property of tendons repaired with modified Kessler suture combined " 8" suture, and to provide evidence for clinical application this methods in repairing acute Achilles tendon rupture.Forty frozen flexor digitorum longus from fresh pork hind leg were randomly assigned into 4 groups, 10 specimens each group. In group A, dissected transversely at midpoint forming model cutting injury. The groups B, C, D midpoint, then a 2 cm segment incision side was...
Objective: To compare the clinical therapeutic effects of arterial first approach pancreaticoduodenectomy(AFA-PD) with standard pancreaticoduodenectomy(SPD) in treatment borderline resectable pancreatic cancer (BRPC). Methods: A retrospective analysis data 113 cases patients from January 2014 to August 2015 at Department Hepato-Biliary-Pancreatic Surgery, Changhai Hospital, Second Military Medical University, including 43 AFA-PD group and 70 SPD group.Every patient had gone high-resolusion...
S: Abstracts of Papers Accepted for Presentation at the Annual Meeting Society Developmental and Behavioral Pediatrics: October 3-4, 2004 Chicago, Illinois: Presented as Posters Sunday, 3,
THURSDAY AFTERNOON - MINI ORAL ABSTRACTS: Cardiac and Metabolic Complications of Transplantation: PDF Only
Purpose: To investigate the healing effect of Shaoshang Yuhe yihao (SYY) in a deep second-degree burns model rats.Methods: Female Wistar rats, weighing 200 - 220 g, were subjected to skin by electrical scald instrument. The animals divided into three groups as follows: (1) (control) group, (2) moist exposed ointment-treated group (positive control drug), and (3) SYY groups. rats treated with for 21 consecutive days. rate healing, scabs dropped time re-epithelialization observed every days...
Objective: To identify the relative factors of female patients with primary overactive bladder. determine whether medical interfered-pelvic floor muscle training and behavioral therapy can enhance treatment effects tolterodine on bladder (OAB).
Objective To investigate the overall risk factors of PPDH together with a subgroup analysis for different clinical conditions, and provide strategies diagnosis treatment individually precisely. Methods Clinical data pancreaticoduodenectomy (PD) patients in Department General Surgery, Sun-Yat-Sen Memorial Hospital University from September 2009 to March 2015 were analyzed retrospectively. Overall risk-factor was conducted, conducted subsequently according time, sites, severity,...