A5101619890- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Advanced materials and composites
- Powder Metallurgy Techniques and Materials
- Additive Manufacturing Materials and Processes
- Hepatocellular Carcinoma Treatment and Prognosis
- Surface Treatment and Residual Stress
- Protein Tyrosine Phosphatases
- Metal Alloys Wear and Properties
- Injection Molding Process and Properties
- MicroRNA in disease regulation
- High Entropy Alloys Studies
- Cancer-related molecular mechanisms research
- Optical Network Technologies
- Additive Manufacturing and 3D Printing Technologies
- Metallurgy and Material Forming
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Welding Techniques and Residual Stresses
- Kruppel-like factors research
- Wnt/β-catenin signaling in development and cancer
- Cellular and Composite Structures
Sun Yat-sen Memorial Hospital
2010-2024
Sun Yat-sen University
2010-2024
South China University of Technology
2012-2023
Guilin University of Electronic Technology
2023
Hunan Agricultural University
2022
Institute of New Materials
2019-2020
Third Affiliated Hospital of Guangzhou Medical University
2017
Guangzhou Medical University
2017
Huawei Technologies (China)
2011-2014
China Aerospace Science and Industry Corporation (China)
2010
Hepatitis B virus X protein (HBx) is involved in the initiation and progression of hepatocellular carcinoma (HCC) by regulating host protein-coding genes. In this study, we showed that HBx altered expression microRNAs (miRNAs) to promote proliferation transformation malignant hepatocytes vitro.miRNA microarray quantitative reverse-transcription polymerase chain reactions (qRT-PCRs) were performed identify miRNAs differentially regulated HCC cells. Protein, mRNA, miRNA analyses; cell cycle...
Long noncoding RNAs (lncRNAs) are involved in a variety of biological processes such as tumor proliferation and metastasis. A close relationship between hepatitis B virus X protein (HBx) SMYD3 promoting the metastasis hepatocellular carcinoma (HCC) was recently reported. However, exact oncogenic mechanism HBx-SMYD3 remains unknown. In this study, by performing lncRNA microarray analysis, we identified novel that regulated both HBx SMYD3, named it lncIHS (lncRNA intersection microarray)....
Mechanical and corrosion behaviors perpendicular to build direction (XOY) along (XOZ) of UNS S31803 duplex stainless steel (DSS) fabricated by laser powder bed fusion (LPBF) were investigated. With the post-annealing, exhibited a ferrite-austenite microstructure. For XOY plane, austenite displayed primarily <101> texture while ferrite kept <001> preferred orientation, mainly held Nishiyama-Wassermann orientation relationship. However, for XOZ showed mixed texture. The average size grains was...
Both lysine and arginine methyltransferases are thought to be promising therapeutic targets for malignant tumors, yet how these function in especially hepatocellular carcinoma (HCC), has not been fully elucidated. Here, we reported that SMYD4, a methyltransferase, acts as an oncogene HCC. SMYD4 was highly upregulated HCC promoted cell proliferation metastasis. Mechanistically, PRMT5, well-known identified SMYD4-binding protein. monomethylated PRMT5 enhanced the interaction between MEP50,...
Ti–35Nb–7Zr–5Ta biomedical alloys were fabricated by spark plasma sintering of nanocrystalline powders mechanical alloying. After 60 h milling, mixtures respective elemental transformed into a homogeneous structure completed β-Ti solid solution. The grain size the milled powder was ∼9 nm. Subsequently, obtained nanosized grained consolidated bulk form at different parameters. At temperature 1373 K, reached nearly full density. microstructure hcp α-Ti regions surrounded bcc regions. In...
BACKGROUND: Tumor metastasis is the major reason for poor prognosis of hepatocellular carcinoma (HCC) patients after hepatic resection. SMYD3 has been demonstrated to promote liver tumor in mice. However, detailed molecular mechanism still largely unknown.The effect on invasiveness and HCC was analyzed by immunohistochemistry, migration assay, invasion wound healing assay vivo lung assay. Mass spectrometry analysis conducted using proteins pulled down H3K4me3 antibody SMYD3-overexpressing...
Abstract Hepatitis B x protein (HBx) affects cellular expression and participates in the tumorigenesis progression of hepatitis virus (HBV)-related hepatocellular carcinoma (HCC). Metabolic reprogramming contributed to HCC development, but its role HBV-related remains largely unclear. Tyrosine-protein phosphatase nonreceptor type 13 (PTPN13) is a significant regulator tumor however, specific hepatocarcinogenesis be explored. Here, we found that decreased PTPN13 was associated with HBV/HBx....
Poly(lactic acid) (PLA) as a promising bio-plastic will decompose to small molecule flammable volatiles via chain scission, which thus exhibit poor fire safety and highly restrict its real-world applications.
Hepatitis B virus X protein (HBx) is considered as an oncogene in tumorigenesis and progression of hepatocellular carcinoma (HCC). In recent years, the important role circular RNAs (circRNAs) HCC has been increasingly demonstrated. However, regulatory mechanisms HBx on circRNAs remains largely unknown. this study, we identified that a novel circRNA, circSFMBT2, was markedly downregulated by HBx. Low expression circSFMBT2 correlated with poor prognosis vascular invasion. Functionally,...
Background: In addition to protein tyrosine kinases, accumulating evidence has shown that phosphatases (PTPs) are suitable therapeutic targets in cancer. PRL-3 is a PTP member been well studied many malignant tumours. The goal of the present study was elucidate role hepatocellular carcinoma (HCC), which remains largely unknown. Methods: Bioinformatic and immunohistochemical analyses were performed analyse expression HCC tissue samples determine its clinical relevance. gene copy number...
Increasing evidence has suggested inositol polyphosphate 5-phosphatase family contributes to tumorigenesis and tumor progression. However, the role of INPP5F in hepatocellular carcinoma (HCC) its underlying mechanisms is unclear.The expression HCC was analyzed public databases our clinical specimens. The biological functions were investigated vitro vivo. molecular mechanism regulating growth studied by transcriptome-sequencing analysis, mass spectrometry immunoprecipitation assay...
Vessels-encapsulate tumor cluster (VETC) is a vascular pattern distinct from classical capillary-like pattern. It reported that VETC structure common in hepatocellular carcinoma (HCC) and can promote HCC metastasis an epithelial-mesenchymal transition (EMT)-independent but VETC-dependent manner. However, the main metastatic manner of containing both (we called
Three different types of Ti6Al4V powders produced by electrode induction melting gas atomization (EIGA), plasma rotating process (PREP), and (PA) were compared from these aspects: particle size distribution, shape, microstructure. Theywere characterized shape analyzer, scanning electron microscope, X-ray diffraction. The results show some benefits using PA powder in selective beam melting. distribution bimodal, the had narrowest span. roundness elongation, bluntness index most analyzed...