A5114124866- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- MRI in cancer diagnosis
- Neurogenesis and neuroplasticity mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Pain Mechanisms and Treatments
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Mitochondrial Function and Pathology
- Neuroscience and Neural Engineering
- Neonatal Respiratory Health Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical Research and Treatments
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Amino Acid Enzymes and Metabolism
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Healthcare and Venom Research
- Schizophrenia research and treatment
- Molecular Sensors and Ion Detection
Hebei Medical University
2014-2024
Queen's University
2024
GTx (United States)
2024
Sun Yat-sen University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Second Hospital of Shanxi Medical University
2020-2024
Shanxi Medical University
2020-2024
State Ethnic Affairs Commission
2024
Southwest Minzu University
2024
Shanghai Jiao Tong University
2009-2020
Correction of echo planar imaging (EPI)-induced distortions (called "unwarping") improves anatomical fidelity for diffusion magnetic resonance (MRI) and functional investigations. Commonly used unwarping methods require the acquisition supplementary images during scanning session. Alternatively, can be corrected by nonlinear registration to a non-EPI acquired structural image. In this study, we compared reliability using two unwarping: 1) image symmetric normalization implemented in Advanced...
Glial glutamate transporter-1 (GLT-1) plays an essential role in the maintenance of homeostasis and is involved development pathological pain. The present study was undertaken (1) to observe anti-nociceptive effects ceftriaxone (Cef) a chronic neuropathic pain model induced by constrictive nerve injury (CCI) sciatic (2) identify spinal GLT-1 process. CCI significant thermal hyperalgesia mechanical allodynia, which began from postoperative day 3 lasted 21. This long-term accompanied...
Alzheimer's disease (AD) is characterized by progressive impairment of learning, memory, and cognitive deficits. Glutamate the major excitatory neurotransmitter in central nervous system plays an important role cognition. The homeostasis reutilization glutamate are dependent on astrocytic uptake transporter-1 (GLT-1) subsequent glutamate-glutamine cycle. Increasing evidence showed impairments GLT-1 expression activity cycle AD. Ceftriaxone (Cef) has been reported to upregulate GLT-1....
The nature of hippocampal changes in schizophrenia before first treatment, and whether subfields are affected by antipsychotic treatment important questions for research. Forty-one first-episode antipsychotic-naïve acutely ill inpatients had MRI scans six weeks after treatment. Thirty-nine matched healthy controls were also scanned, twenty-two which scanned a second time later. Volumes measured via FreeSurfer v6.0 using longitudinal analysis pipeline. Before patients no significant total...
Glial glutamate transporter-1 (GLT-1) plays an essential role in removing from the extracellular space and maintaining below neurotoxic level brain. To explore whether GLT-1 a acquisition of brain ischemic tolerance (BIT) induced by cerebral preconditioning (CIP), present study was undertaken to observe vivo changes expression glial fibrillary acidic protein (GFAP) CA1 hippocampus during induction BIT, effect dihydrokainate (DHK), inhibitor GLT-1, on BIT rats. Immunohistochemistry for GFAP...
This study was undertaken to determine the role of glutamate transporter-1a (GLT-1a), one splice variants transporter-1, in induction brain ischemic tolerance by cerebral preconditioning (CIP). We used a rat global model and assessed changes neuropathological evaluation, Western blot analysis, immunohistochemistry, real-time PCR, vivo microdialysis, high performance liquid chromatography. found that CIP induced significant upregulation GLT-1a expression CA1 hippocampus time course...
To identify the correlation between magnetic resonance manifestation and survival of patients with glioblastoma multiforme (GBM).The imaging (MRI) images 30 were collected. Imaging features including degrees contrasted area, edema surrounding tumor, intensity in T2-weighted selected to determine their patient survival. The relationship time was studied using SPSS 19.0 software. Kaplan-Meier analysis log-rank test used compare curves.Patients ≤5% enhancement area tumor had longer overall (OS)...
Abstract Amyloid beta (Abeta) synergistically enhances excitotoxicity of glutamate load by impairing transporter 1 (GLT1) expression and function, which exacerbates the development Alzheimer’s disease (AD). Our previous studies suggested that sulbactam can upregulate levels capacity GLT1. Therefore, this study aims to investigate whether improves neuronal tolerance against neurotoxicity Abeta up-regulating GLT1 in primary neuron-astrocyte co-cultures. Early postnatal P0–P1 Wistar rat pups’...
Alzheimer's disease (AD) is a progressive neurodegenerative dementia with the key pathological hallmarks amyloid-beta deposition and neurofibrillary tangles composed of hyperphosphorylated tau. microRNAs (miRNAs) are small non-coding RNAs that contribute to pathogenesis AD. In this study, we investigated effect loss miR-369 on phosphorylation tau protein activation kinases Fyn serine/threonine-protein kinase 2 (SRPK2) as upstream molecules facilitating in knockout 3xTg-AD mice.We generated...