A5029011351- Spaceflight effects on biology
- Bone health and osteoporosis research
- Electromagnetic Fields and Biological Effects
- Trace Elements in Health
- Bone Metabolism and Diseases
- Iron Metabolism and Disorders
- Hip and Femur Fractures
- High Altitude and Hypoxia
- Bone Tissue Engineering Materials
- Vitamin D Research Studies
- Erythrocyte Function and Pathophysiology
- Circadian rhythm and melatonin
- Parathyroid Disorders and Treatments
- Medical and Biological Ozone Research
- Exercise and Physiological Responses
- Fibroblast Growth Factor Research
- Bone and Joint Diseases
- Bone fractures and treatments
- Bone health and treatments
- Winter Sports Injuries and Performance
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Textile materials and evaluations
- Hemoglobinopathies and Related Disorders
- Magnetic and Electromagnetic Effects
Xi'an Honghui Hospital
2021-2025
Xi'an Jiaotong University
2021-2025
Southern Medical University
2005-2024
Northwestern Polytechnical University
2016-2023
Ningxia Medical University
2023
Zhujiang Hospital
2014-2023
Shenyang Agricultural University
2023
ShenZhen People’s Hospital
2019-2021
China Academy of Space Technology
2018
University of Tennessee Health Science Center
2015-2016
Clinical studies, epidemiological investigations and animal experiments have demonstrated that iron overload lead to bone loss, especially postmenopausal osteoporosis. As a physiotherapy tool, electromagnetic fields already used in clinical treatment of osteoporosis participates remodeling by affecting the metabolism organisms. an field with constant magnetic flux density direction, mechanism static (SMF) regulating remains unclear. Therefore, aim this study was investigate effects moderate...
Mechanisms underlying the association between fibroblastic growth factor 23 ( FGF ‐23) and inflammation are uncertain. We found that ‐23 was markedly up‐regulated in LPS / INF ‐γ‐induced proinflammatory M1 macrophages Hyp mouse‐derived peritoneal macrophages, but not IL ‐4‐induced M2 anti‐inflammatory macrophages. NF ‐КB JAK STAT 1 pathways mediated increased transcription of response to polarization. stimulated TNF ‐α, ‐6, expression M0 suppressed Arginase‐1 through FGFR ‐mediated...
Many studies have indicated that static magnetic fields (SMFs) positive effects on bone tissue, including formation and healing process. Evaluating the of SMFs cell (especially osteoblast) function exploring mechanism, which is critical for understanding possible risks or benefits from to balance remodeling. Iron natural relationship, iron an essential element normal metabolism. overload deficiency can cause severe disorders osteoporosis. However, there are few reports regarding role in...
A postnatal role of fibroblast growth factor receptor-1 (FGFR1) in the kidney is suggested by its binding to α-Klotho form an obligate receptor for hormone factor-23 (FGF-23). FGFR1 expressed both proximal and distal renal tubular segments, but specific functions are unclear. In this study, we crossed Fgfr1flox/flox mice with either gamma-glutamyltransferase-Cre (γGT-Cre) or specific-Cre (Ksp-Cre) selectively create tubule (PT) (DT) Fgfr1 conditional knockout (designated Fgfr1PT-cKO...
Abstract Iron metabolism is crucial to hepatocellular carcinoma progression and a key determinant of prognosis. Protein‐protein interactions within the iron gene network were analyzed using European Molecular Biology Laboratory's Search Tool for Recurring Instances Neighbouring Genes/Proteins database. We obtained 423 liver expression profiles from Cancer Genome Atlas The pathway enrichment representative intake genes ( TFRC DMT1 ), utilization FTH1 , FTL HIF1A HMOX1 SLC25A37 SLC25A38 efflux...
Rheumatoid arthritis (RA) is a chronic autoimmune disease in which synovial fibroblast-like cells (FLSs) play an important role RA development and known to be lack of effective therapy. Thus, novel therapeutic strategies are greatly needed for treatment RA. Metformin, first-line drug the type 2 diabetes, has been reported inhibit proliferation variety tumor cells. In this study, we demonstrated that metformin could RA-FLS dose- time-dependent manner. Our cell viability MTT test...
This article reviews the current development of nanoparticles on bone tissue engineering & cells and potential mechanisms effects NPs cell to potentially reveal new therapeutic strategies improve effectiveness regeneration therapy.
The accumulation of intracellular reactive oxygen species (ROS) is widely recognized to stimulate the development osteoclasts, a crucial factor in onset osteoporosis. ROS scavenging capability Prussian blue nanoparticles (PBNPs) exceptional, and they possess excellent biocompatibility. However, effects PBNPs on osteoporosis remain unknown. Present study aimed investigate whether could inhibit osteoclast differentiation prevent ovariectomy (OVX)-induced bone loss by suppressing ROS. In vitro...
Abstract Osteoporosis is one of the chronic complications type 1 diabetes with high risk fracture. The prevention diabetic osteoporosis particular importance. Static magnetic fields (SMFs) exhibit advantages on improvement complications. biological effects and mechanism SMFs bone health mice functions cells under glucose have not been clearly clarified. In animal experiment, six‐week‐old male C57BL/6J were induced to exposed SMF 0.4–0.7 T for 4 h/day lasting 6 weeks. Bone mass, biomechanical...
With the deepening of magnetic biomedical effects and electromagnetic technology, some medical instruments based on static field (SMF) have been used in orthopedic-related diseases treatment. Studies shown SMF could combat osteoporosis by regulating differentiation mesenchymal stem cells (MSCs), osteoblast osteoclast. development nanotechnology, iron oxide nanoparticles (IONPs) reported to regulate process bone anabolism. As for combined with IONPs, studies indicated osteogenic MSCs were...
Bone remodeling is affected by mechanical stimulation. Osteocytes are the primary load-sensing cells in bone, and can regulate osteoblast osteoclast activity, thus playing a key role bone remodeling. Further, mass during exercise also regulated Leukemia inhibitory factor (LIF). This study aimed to investigate of LIF response vivo vitro, elucidate mechanism which osteocytes secrete osteoblasts osteoclasts.A tail-suspension (TS) mouse model was used this mimic muscular disuse. ELISA...