A5042843937- Spaceflight effects on biology
- Ferroptosis and cancer prognosis
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Electromagnetic Fields and Biological Effects
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Bioactive natural compounds
- Drug Transport and Resistance Mechanisms
- Bone health and osteoporosis research
- Iron Metabolism and Disorders
- Genomics, phytochemicals, and oxidative stress
- Trace Elements in Health
- Vitamin C and Antioxidants Research
- Hemoglobinopathies and Related Disorders
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Endoplasmic Reticulum Stress and Disease
- Phytochemicals and Antioxidant Activities
- Magnetic and Electromagnetic Effects
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Autophagy in Disease and Therapy
- RNA regulation and disease
- Medicinal plant effects and applications
Fujian Agriculture and Forestry University
2024
Chinese Academy of Agricultural Sciences
2024
Institute of Animal Sciences
2024
Northwestern Polytechnical University
2018-2023
Xi'an Jiaotong University
2023
Henan University of Traditional Chinese Medicine
2023
National Clinical Research Center for Digestive Diseases
2021-2022
Xijing Hospital
2021-2022
Xi'an Medical University
2021-2022
Air Force Medical University
2022
Osteosarcoma is the most common primary malignancy of skeleton in children and adults. The outcomes people with osteosarcomas are unsatisfied. β -Phenethyl isothiocyanate (PEITC) exhibits chemoprevention chemotherapeutic activities against many human cancers. molecular mechanism underlying its action on osteosarcoma still unknown. This study was aimed at investigating effect PEITC both vitro vivo . results showed that reduced cell viability, inhibited proliferation, caused G 2 /M cycle...
Abstract Iron metabolism is crucial to hepatocellular carcinoma progression and a key determinant of prognosis. Protein‐protein interactions within the iron gene network were analyzed using European Molecular Biology Laboratory's Search Tool for Recurring Instances Neighbouring Genes/Proteins database. We obtained 423 liver expression profiles from Cancer Genome Atlas The pathway enrichment representative intake genes ( TFRC DMT1 ), utilization FTH1 , FTL HIF1A HMOX1 SLC25A37 SLC25A38 efflux...
Abstract Osteoporosis is one of the chronic complications type 1 diabetes with high risk fracture. The prevention diabetic osteoporosis particular importance. Static magnetic fields (SMFs) exhibit advantages on improvement complications. biological effects and mechanism SMFs bone health mice functions cells under glucose have not been clearly clarified. In animal experiment, six‐week‐old male C57BL/6J were induced to exposed SMF 0.4–0.7 T for 4 h/day lasting 6 weeks. Bone mass, biomechanical...
Osteosarcoma is a common malignant bone tumor in clinical orthopedics. Iron chelators have inhibitory effects on many cancers, but their and mechanisms osteosarcoma are still uncertain. Our vitro results show that deferoxamine (DFO) deferasirox (DFX), two iron chelators, significantly inhibited the proliferation of cells (MG-63, MNNG/HOS K7M2). The viability was decreased by DFO DFX concentration-dependent manner. generated reactive oxygen species (ROS), altered metabolism triggered...
Abstract Osteosarcoma is the most common primary bone malignancy in children and young adults, with a very poor prognosis. It of great importance to develop targeted therapeutic strategies for osteosarcoma. Sulfasalazine (SAS) an FDA-approved drug treatment Crohn’s disease, rheumatoid arthritis, inflammatory bowel disease. acts as inhibitor cystine/glutamate system, which important cellular glutathione synthesis maintenance GPx4 activity. Nowadays, SAS has been repurposed antitumor inducing...
Purpose Bone loss is one of the most serious medical problem associated with prolonged weightlessness in long-term spaceflight mission. Skeletal reloading after have indicated incomplete recovery lost bone, which may lead to an increased risk fractures astronauts when returning Earth. Substantial studies revealed capacity static magnetic fields (SMFs) on treating various bone disorders, whereas it unknown whether SMFs potential regulatory effects quality unloaded mice during unloading. This...
Osteocytes are the mechano-sensors of bones. Large gradient high-static magnetic fields (LG-HMFs) produce stable, high-precision, and non-attenuation mechanical forces. We discovered that forces opposite to gravity inhibited MLO-Y4 osteocyte proliferation viability by inducing structural damage apoptosis. In contrast, force loading in same direction as promoted apoptosis osteocytes. Differentially expressed gene (DEG) analysis after stimulation indicated ECM-integrin-CSK axis responded most...