A5033458976- Advanced Neuroimaging Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Spinal Dysraphism and Malformations
- Nerve injury and regeneration
- Systemic Lupus Erythematosus Research
- Tryptophan and brain disorders
- Medication Adherence and Compliance
- Chronic Disease Management Strategies
- Memory Processes and Influences
- Diabetes Management and Education
- Receptor Mechanisms and Signaling
- Gout, Hyperuricemia, Uric Acid
- Multiple Myeloma Research and Treatments
- MRI in cancer diagnosis
- Cancer, Stress, Anesthesia, and Immune Response
- Substance Abuse Treatment and Outcomes
- Cervical and Thoracic Myelopathy
University of Minnesota Medical Center
2020-2024
University of North Carolina at Chapel Hill
2008-2024
Seattle University
2023
Imaging Center
2017-2022
University of Washington
2016-2022
Institute for Behavioral Medicine
2018
University of Colorado Boulder
2018
East Tennessee State University
2013-2017
Kennedy Krieger Institute
2009-2015
Virginia Commonwealth University
2015
Correction of echo planar imaging (EPI)-induced distortions (called "unwarping") improves anatomical fidelity for diffusion magnetic resonance (MRI) and functional investigations. Commonly used unwarping methods require the acquisition supplementary images during scanning session. Alternatively, can be corrected by nonlinear registration to a non-EPI acquired structural image. In this study, we compared reliability using two unwarping: 1) image symmetric normalization implemented in Advanced...
Medication nonadherence, inconsistent patient self-monitoring, and inadequate treatment adjustment exacerbate poor disease control. In a collaborative, team-based, care management program for complex patients (TEAMcare), we assessed physician behaviors (medication adherence, adjustment) in achieving better outcomes diabetes, coronary heart disease, depression.A randomized controlled trial was conducted (2007-2009) 14 primary clinics among 214 with poorly diabetes (glycated hemoglobin...
Advanced dementia is characterized by severe cognitive impairment and complete functional dependence. Patients' goals of care should guide the prescribing medication during such terminal illness. Medications that do not promote primary goal be minimized.
For patients to effectively manage gout, they need be aware of the impact diet, alcohol use, and medications on their condition. We sought examine patients' knowledge beliefs concerning gout its treatment in order identify barriers optimal patient self-management. identified (≥18 years age) cared for setting a multispecialty group practice with documentation at least one health care encounter associated diagnosis during period 2008–2009 (n = 1346). Patients were sent questionnaire assessing...
Diffusion tensor imaging data were collected at 3.0 Tesla from 16 children with attention-deficit hyperactivity disorder (ADHD) and typically developing controls, ages 9 to 14 years. Fractional anisotropy images calculated normalized by linear transformation. Voxel-wise atlas-based region-of-interest analyses performed. Using voxel-wise analysis, fractional was found be significantly increased in the group right superior frontal gyrus posterior thalamic radiation, left dorsal cingulate...
Objectives To describe patterns of, and factors associated with, statin use discontinuation in nursing home ( NH ) residents progressing to advanced dementia followed for at least 90 days. Design Retrospective inception cohort using a dataset linking 2007 2008 M inimum D ata S et MDS edicare denominator P art files. Setting All s five states innesota, assachusetts, ennsylvania, C alifornia, F lorida). Participants with dementia. Measurements Residents who developed were observed from...
Despite several expert panel recommendations and cellulitis treatment guidelines, there are currently no clinical decision rules to assist clinicians in deciding which emergency department (ED) patients should be treated with oral antibiotics require intravenous (IV) therapy at first presentation of amenable outpatient treatment. The objective was determine risk factors associated adult presenting the ED who fail initial antibiotic as outpatients a change or admission hospital. This...
Abstract Stress has been reported to activate the locus coeruleus (LC)–noradrenergic system. In this study, corticosterone (CORT) was orally administrated rats for 21 days mimic stress status. situ hybridization measurements showed that CORT ingestion significantly increased mRNA levels of norepinephrine transporter (NET) and dopamine β‐hydroxylase (DBH) in LC region. Immunofluorescence staining western blotting revealed treatment also protein NET DBH LC, as well hippocampus, frontal cortex...
Current theories of the neurobiological basis autism spectrum disorder ( ASD ) posit an altered pattern connectivity in large‐scale brain networks. Here we used diffusion tensor imaging to investigate microstructural properties white matter WM that mediates interregional 36 high‐functioning children with HF‐ASD as compared 37 controls. By employing atlas‐based analysis using large deformation diffeometric morphic mapping registration, a widespread but left‐lateralized abnormalities was...
The contribution of this paper is to describe how we can program neuroimaging workflow using Make, a software development tool designed for describing build executables from source files. We show that achieve many the features more sophisticated pipeline systems, including reproducibility, parallelization, fault tolerance, and quality assurance reports. suggest Make represents large step towards these with only modest increase in programming demands over shell scripts. This approach reduces...
The contribution of this paper is to identify and describe current best practices for using Amazon Web Services (AWS) execute neuroimaging workflows "in the cloud." Neuroimaging offers a vast set techniques by which interrogate structure function living brain. However, many scientists whom an extremely important tool have limited training in parallel computation. At same time, field experiencing surge computational demands, driven combination data-sharing efforts, improvements scanner...
BACKGROUND To the authors' knowledge, few studies to date have examined adherence recommended guidelines for follow‐up and outcomes after an unsatisfactory Papanicolaou (Pap) test (UPT) with liquid‐based technologies. METHODS Within 4 US health plans, median time percentage of patients testing by 120 days was calculated a UPT. Multivariable analyses evaluated association between clinical factors testing. The authors compared risk diagnosis cervical intraepithelial neoplasia type 2 or worse...
Down syndrome (DS) results from the triplication of genes located on human chromosome 21 (Hsa21). Though many cognitive and behavioral impairments are associated with DS, sleep disturbances remain poorly understood despite being a reported phenotype in approximately 60% individuals diagnosed DS. In this study, electroencephalography (EEG) oscillations were recorded aged (12–14 mos.) Dp(16)1Yey/+ mice (Dp16), mouse model We observed disrupted demonstrated by increased activity during dark...
This study analyzed the role of dopamine D<sub>1</sub> and D<sub>2</sub> receptors in methylphenidate (MPH) conditioned place preference (CPP) adolescent male female rats, addition to these effects MPH on brain-derived neurotrophic factor (BDNF) dorsal striatum nucleus accumbens. Using a nonbiased CPP procedure, animals were from postnatal day (PD) 33 37. On conditioning trials, first administered saline or their respective antagonist (0.1 0.2 mg/kg SCH-23390; 0.01...