A5089370644- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- RNA modifications and cancer
- Gut microbiota and health
- Animal Virus Infections Studies
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Oral Health Pathology and Treatment
- Biological Activity of Diterpenoids and Biflavonoids
- Microbial Natural Products and Biosynthesis
- Respiratory viral infections research
- Olfactory and Sensory Function Studies
- Ubiquitin and proteasome pathways
- Hepatitis Viruses Studies and Epidemiology
- Natural product bioactivities and synthesis
- Advanced Chemical Sensor Technologies
- SARS-CoV-2 and COVID-19 Research
- Biochemical Analysis and Sensing Techniques
- Oral microbiology and periodontitis research
- Hepatitis B Virus Studies
- Animal Disease Management and Epidemiology
- Hepatitis C virus research
- RNA Research and Splicing
Fudan University
2023-2025
Zhongshan Hospital
2025
State Key Laboratory of Genetic Engineering
2024
Hebei General Hospital
2021
North China University of Science and Technology
2021
Donghua University
2012-2013
Dalhousie University
2012-2013
Emerging evidence has highlighted that olfactory dysfunction, a common feature of aging, is increasingly linked to cognitive decline in older adults. However, research on the underlying mechanism, particularly role nasal microbiome, remains limited. In this study, we investigated associations between function, and cognition among 510 adults with an average age 77.9 years. Olfactory function was assessed using brief Chinese Smell Identification Test, assessments were conducted via Mini-Mental...
Protein trans-splicing by split inteins has many uses in protein production and research. Splicing proteins with synthetic peptides, which employs atypical inteins, is particularly useful for site-specific modifications labeling, because the peptide can be made to contain a variety of unnatural amino acids chemical modifications. For this purpose, need engineered have small N-intein or C-intein fragment that more easily included also contains extein trans-spliced onto target proteins. Here...
Recurrent oral ulcer (ROU) is a prevalent and painful disorder with implications beyond physical symptoms, impacting quality of life necessitating comprehensive management. Understanding the interplays between dietary factors, microbiota, ROU crucial for developing targeted interventions to improve systemic health. Dietary behaviors plant-based diet indices including healthful index (hPDI) were measured based on validated food frequency questionnaire. Saliva microbial features profiled using...
Heterologous vaccine schedules have been recommended to provide superior immunity and protection against emergent SARS-CoV-2 variants of concern. We aimed evaluate the safety, immunogenicity, efficacy an mRNA COVID-19 RQ3013 compared with adenoviral vectored Ad5-nCoV protein subunit ZF2001 as fourth dose in adults primed three doses inactivated vaccines China.
Inteins catalyze a protein splicing reaction to excise the intein from precursor and join flanking sequences (exteins) with peptide bond. In split intein, fragments (IN IC) can reassemble non-covalently trans-splicing that joins exteins separate polypeptides. An atypical having very small IN large IC is particularly useful for joining synthetic peptides recombinant proteins, which be generally method of introducing site-specific chemical labeling or modifications into proteins. However,...
<title>Abstract</title> Emerging evidence has highlighted that olfactory dysfunction, a common feature of aging, is increasingly linked to cognitive decline in older adults. However, research on the underlying mechanism, particularly role nasal microbiome, remains limited. In this study, we investigated associations between function, and cognition among 510 adults with an average age 77.9 years. Olfactory function was assessed using brief Chinese Smell Identification Test, assessments were...
Inteins are internal proteins inside precursor and can be viewed as the protein equivalent of introns. catalyze a splicing reaction that excises intein sequence from joins flanking sequences (N- C-exteins) with peptide bond. Split inteins, in which is broken into two pieces (IN IC), trans-splicing exteins separate proteins. Protein has become powerful tool engineering, have included fusion polypeptides, segmental production labeling proteins, site-specific addition chemical modifications or...
Objective To inquire into the molecular epidemiology of enterovirus 71(EV71) in our region by analyzing whole genome characteristics and genetic evolution EV 71 strains isolated from Guizhou area. Methods The throat swabs samples hospitalized children with hand, foot mouth disease province 2013 to 2015 were collected, virus nucleic acid extracted, then piecewise amplified reverse transcription polymerase chain reaction(RT-PCR) sequenced.Sequencing results edited spliced DNAMAN8.0...
<i>Background.</i> Although the traditional Chinese medicine Prunella vulgaris may be effective in treating lymphoma, its mechanism of action remains unclear. The purpose this paper is to explore against lymphoma by combining network pharmacology and molecular docking. <i>Methods.</i> potential active ingredients were queried TCMSP database. Lymphoma-related genes searched DisgeNet After removing duplicates, remaining targets compared with obtain key target analyzed using a Venn map....