A5100321407- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Nasolacrimal Duct Obstruction Treatments
- Multiple Myeloma Research and Treatments
- Metabolomics and Mass Spectrometry Studies
- Systemic Lupus Erythematosus Research
- Head and Neck Surgical Oncology
- Retinal Development and Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Drug-Induced Ocular Toxicity
- Barrier Structure and Function Studies
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Protein Degradation and Inhibitors
- Retinal and Macular Surgery
- Ophthalmology and Eye Disorders
- Advanced Glycation End Products research
Xuzhou Central Hospital
2025
Shanghai Tenth People's Hospital
2017-2025
Tongji University
2017-2025
Shanghai Eye Disease Prevention & Treatment Center
2023
Shenyang Pharmaceutical University
2020
Xian Yang Central Hospital
2017-2018
First Affiliated Hospital of Sichuan Medical University
2013
ABSTRACT Proteolysis targeting chimera (PROTAC) has been developed and currently enjoys widespread interest among the field of pharmaceutical manufacturing in recent decades. NX‐5948 is an orally active PROTAC Bruton tyrosine kinase degrader, which shows anti‐inflammatory antitumor activities. In this study, a simple fast bioanalytical method for quantification beagle dog plasma was using liquid chromatography–tandem mass spectrometry (LC‐MS/MS). A full validation performed according to...
Purpose Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells contributes to the epiretinal membrane development in proliferative vitreoretinopathy (PVR). This study aimed at investigating changes mitochondrial function during EMT PVR.
To characterize the vascular changes in eyes within acute phase of retinal arterial occlusion (RAO) by optical coherence tomography angiography (OCT-A) imaging. This was a retrospective, observational study. Nineteen patients with RAO (symptom onset 7 days) and 19 age sex-matched normal control individuals were included. A comprehensive ophthalmic examination OCT-A conducted for all patients. The vessel density superficial capillary plexus (SCP), deep (DCP), area width 300 μm around FAZ...
Abstract In order to analyze the interocular correlation of vascular density, foveal avascular zone (FAZ) size, central macular thickness (CMT), and investigate relationship between density CMT in normal eyes, retinal superficial capillary plexus (SCP), deep (DCP) choriocapillaris (CC) networks, FAZ were visualized by optical coherence tomography (OCT) angiography. A total 174 eyes 87 Chinese subjects enrolled study. The results showed that measurements are not statistically significant...
Purtscher-like retinopathy is a rare and vision-threatening eye disease, which usually associated with acute pancreatitis, autoimmune diseases, renal failure. We here reported case of after dupilumab treatment in atopic dermatitis.
In the present study, efficacy of three consecutive anti‑VEGF treatments in patients with neovascular macular degeneration (nAMD) was assessed by optical coherence tomography angiography (OCT‑A). A total 23 eyes nAMD were treated intravitreal injections (IVIs) ranibizumab once a month for months. There eight follow‑up time‑points: Prior to initial IVI and on days 1, 3, 7, 14, 30, 60 90 after first IVI. The examinations consisted measurements best‑corrected visual acuity (BCVA), height...
Abstract A bioanalytical method for simultaneous quantification of isoniazid (INH), pyrazinamide (PZA) and ethambutol (EMB) in plasma was developed validated using high-performance liquid chromatography with tandem mass spectrometry. After extracted by protein precipitation acetonitrile, the analytes were separated on a Waters XBridge Amide column isocratic elution acetonitrile 5 mM ammonium acetate solution containing 0.3% formic acid (77:23, v/v) at flow rate 0.5 mL/min. The detection...
Objective To objectively quantitative assess the visual quality in patients with myopic foveoschisis (MF) using a double-pass optical analysis system (OQASⅡ). Methods Sixty-two subjects participated this cross-sectional, observational study, who were divided into three groups based on pathologic conditions including group (MFG), control (MCG) and normal (NCG). Measurements OQAS Ⅱ performed for modulation transfer function cut off frequency (MTF cut-off), Strehl ratio (SR) objective...
Objective To evaluate the lacrimal drainage tube assisted canaliculus anastomosis for traumatic canalicular laceration.Methods 45 cases with laceration in group A,which was used during repair of laceration.The effect observed after withdrawal 3-4 months later.The results were compared 42 epidural tube,which (group B).Results The 44 successful.The total cure rate 88.87％ groop A,compared 66.67％ that B (postoperative follow-up 6 months).There a significant difference between two groups (x2...
Objective To observe the serum homocysteine (Hcy) levels in retinal branch vein occlusion (BRVO) patients with hypertension or non-hypertension. Methods A total of 120 (120 eyes) BRVO were divided into group [72 eyes, blood pressure 140 - 175/90 105 mmHg (1 mmHg=0.133 kPa)] and non-hypertension (48 100 139/70 88 mmHg). According to sex age, 78 hypertensive non-retinal vascular diseases 48 non-hypertensive collected by a way same-size ratio as control group, respectively. Fasting...