A5101910298- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Studies
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Pharmacogenetics and Drug Metabolism
- Plant-based Medicinal Research
- Essential Oils and Antimicrobial Activity
- Food Quality and Safety Studies
- Metabolomics and Mass Spectrometry Studies
- Visual Attention and Saliency Detection
- Healthcare and Venom Research
- Drug Transport and Resistance Mechanisms
- Spectroscopy and Chemometric Analyses
- Medicinal Plant Pharmacodynamics Research
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Nanoparticle-Based Drug Delivery
- Advanced Synthetic Organic Chemistry
- Alcohol Consumption and Health Effects
- Flavonoids in Medical Research
- Identification and Quantification in Food
- Crystallization and Solubility Studies
- Biofuel production and bioconversion
Jinan University
2016-2025
Xuzhou Central Hospital
2025
Guangdong Pharmaceutical University
2013-2024
Yinchuan First People's Hospital
2024
Beijing Aerospace General Hospital
2024
Xi’an University of Posts and Telecommunications
2024
Anhui Institute of Information Technology
2023-2024
Research Institute of Petroleum Exploration and Development
2018-2024
Zhejiang University
2023
PowerChina (China)
2022
ABSTRACT Introduction In China, Typhae Pollen (TP) has been extensively utilized as a medicinal product, which is the dried pollen from male inflorescences of Typha angustifolia L. (TA), orientalis Presl (TO), or species within same genus. However, existing methods for differentiating botanical origin and controlling quality TP are confusing, unreliable, unsystematic. Objectives This study aims to elucidate microstructural similarities differences between grains two develop comprehensive...
Abstract: Lipid nanocarriers are becoming a versatile platform for oral delivery of lipophilic drugs. In this article, we aimed to explore the gastrointestinal behaviors lipid nanoparticles and effect PEGylation on absorption fenofibrate (FN), Biopharmaceutics Classification System (BCS) II model drug. FN-loaded PEGylated (FN-PLNs) were prepared by solvent-diffusion method characterized particle size distribution, morphology, Fourier transform infrared spectroscopy, drug release. Lipolytic...
The oral delivery of insoluble and enterotoxic drugs has been largely plagued by gastrointestinal irritation, side effects, limited bioavailability. Tripterine (Tri) ranks as the hotspot anti-inflammatory research other than inferior water-solubility biocompatibility. This study was intended to develop selenized polymer-lipid hybrid nanoparticles loading Tri (Se@Tri-PLNs) for enteritis intervention improving its cellular uptake Se@Tri-PLNs were fabricated a solvent diffusion-in situ...
Osteoporosis (OP) is considered as one of the major comorbidities rheumatoid arthritis (RA), and responsible for fragility fracture. However, there currently no effective treatment RA complicated with OP. Tubson-2 decoction (TBD), a Mongolian medicine also known Erwei Duzhong Decoction, has been shown to exert preventive effect on post-menopausal osteoporosis (PMOP). The effects TBD RA-induced OP, well bioactive compound underlying mechanisms, remain be elucidated.To explore OP in vivo,...
We recently found that butyrate could ameliorate inflammation of alcoholic liver disease (ALD) in mice. However, the exact mechanism remains incompletely comprehended. Here, we examined role on ALD-associated through macrophage (Mψ) regulation and polarization using vivo vitro experiments. For experiments, C57BL/6J mice were fed modified Lieber-DeCarli liquid diets supplemented with or without ethanol sodium (NaB). After 6 weeks treatment, euthanized associated indicators analyzed....
Background: Equus asinus L. [Equidae; Asini Corri Colla] (donkey-hide gelatin, E-Jiao) is a traditional Chinese medicine renowned for its exceptional blood-supplementing effect. However, the specific components that contribute to efficacy remain elusive. This study aimed demonstrate peptides are responsible E-Jiao’s effect and explore contributing efficacy. Methods: The low molecular weight of E-Jiao (LMEJ) were obtained using an in vitro digestion method. LMEJ rat bloodstream characterized...
ABSTRACT Proteolysis targeting chimera (PROTAC) has been developed and currently enjoys widespread interest among the field of pharmaceutical manufacturing in recent decades. NX‐5948 is an orally active PROTAC Bruton tyrosine kinase degrader, which shows anti‐inflammatory antitumor activities. In this study, a simple fast bioanalytical method for quantification beagle dog plasma was using liquid chromatography–tandem mass spectrometry (LC‐MS/MS). A full validation performed according to...
Objective The genetic analysis, particularly focusing on the psb A- trn H region, aims to tackle challenges linked myrrh identification and improve quality control in medicinal aromatic plant sectors. This process reveals diversity inherent species, identifies adulterants, assesses consistency with pharmacopoeia-designated species. Methods A meticulous investigation was conducted, involving twenty-five samples sourced from diverse origins one adulterant sample. methodology encompassed...
1. Niclosamide is an old anthelmintic drug that shows potential in fighting against cancers. Here, we characterized the metabolism of niclosamide by cytochrome P450 enzymes (CYPs) and UDP-glucuronosyltransferases (UGTs) using human liver microsomes (HLM) expressed enzymes.2. NADPH-supplemented HLM (and from various animal species) generated one hydroxylated metabolite (M1) niclosamide; UDPGA-supplemented mono-O-glucuronide (M2). The chemical structures M1 (3-hydroxy niclosamide) M2...
1. The natural polyphenol gossypol possesses many therapeutic benefits. Here we aim to determine the elimination pathways of in vivo and vitro.
We aim to determine the chemical constituents of three species Cistanches Herba using HPLC coupled with diode array detection and high-resolution MS. Ten phenylethanoid glycosides were identified further quantified as marker substances by method. The separation was conducted an Agilent TC-C18 column 0.1% formic acid methanol mobile phases under gradient elution. analytical method fully validated in terms linearity, sensitivity, precision, repeatability well recovery, subsequently applied...
Efflux of glucuronide is facilitated by the membrane transporters including BCRP and MRPs. In this study, we aimed to determine effects transporter expression on efflux cellular glucuronidation. Single (i.e., BCRP, MRP1, MRP3, or MRP4) was stably knocked-down in UGT1A1-overexpressing HeLa cells. Knock-down performed stable transfection short-hairpin RNA (shRNA) using lentiviral vectors. Glucuronidation transport cells were characterized three different aglycones genistein, apigenin, emodin)...
Ensiling has been widely applied to cope with agricultural solid waste achieve organic valorization and relieve environmental pressure feedstuff shortage. In this study, co-ensiling of cabbage leaf byproduct rice straw was performed inoculation Lactiplantibacillusplantarum (LP) investigate the effects on ensiling performance microflora profiles. Compared control, LP preserved more dry matter (DM) content (283.4 versus 270.9 g·kg−1 fresh (FM) day 30), increased lactic acid (LA) (52.1 35.8...
Abstract Background Head and neck squamous cell carcinoma (HNSCC) typically present with a complex anatomical distribution, often accompanied by insidious symptoms. This combination contributes to its high incidence poor prognosis. It is now understood that the immune features of cellular components within tumor ecosystem their interactions are critical factors influencing both progression effective response. Methods We obtained single-cell RNA sequencing data 26,496 cells from three tissues...