A5101712964- Nanoparticle-Based Drug Delivery
- Selenium in Biological Systems
- Neurological Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Pharmacogenetics and Drug Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Rice Cultivation and Yield Improvement
- Drug Transport and Resistance Mechanisms
- Tissue Engineering and Regenerative Medicine
- Lanthanide and Transition Metal Complexes
- Electrochemical Analysis and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Magnetic Properties and Synthesis of Ferrites
- Building materials and conservation
- Natural Compounds in Disease Treatment
- Traditional Chinese Medicine Analysis
- Polymer Surface Interaction Studies
- Ginkgo biloba and Cashew Applications
- CO2 Sequestration and Geologic Interactions
- Field-Flow Fractionation Techniques
- Flavonoids in Medical Research
- Echinoderm biology and ecology
- Lipid Membrane Structure and Behavior
- Graphene and Nanomaterials Applications
- Natural Antidiabetic Agents Studies
Peking University Third Hospital
2016-2024
Peking University
2016-2024
Chinese Academy of Sciences
2022
Shenyang Pharmaceutical University
2022
Nanjing Medical University
2021-2022
Hubei University
2021-2022
Shenzhen Institutes of Advanced Technology
2022
Chengdu University of Traditional Chinese Medicine
2021
Southwestern Institute of Physics
2021
Jinan University
2016-2017
The development of a highly efficient, low-toxicity, ultrasmall ferrite nanoparticle-based T1 contrast agent for high-resolution magnetic resonance imaging (MRI) is desirable. However, the correlations between chemical compositions, in vitro relaxivities, vivo nano-bio interactions and toxicities remain unclear, which has been challenge optimizing efficacy. Methods: Ultrasmall (3 nm) manganese nanoparticles (MnxFe3-xO4) with different doping concentrations ions (x = 0.32, 0.37, 0.75, 1, 1.23...
Oral bioavailability of flavonoids (and many phenolic drugs) is severely limited by extensive first-pass glucuronidation. Here we aimed to determine the modulatory effects commonly used pharmaceutical excipients (PEs) on UDP-glucuronosyltransferase (UGT) activities and evaluate potential nanoemulsions containing a UGT-inhibitory PE for oral absorption enhancement chrysin, model flavonoid. The PEs glucuronidation were determined using tissue (liver intestine) microsomes, expressed UGT1A1...
At present, Stroke is still one of the leading causes population death worldwide and leads to disability. Traditional Chinese medicine plays an important role in prevention or treatment stroke. l -borneol, a traditional medicine, has been used China treat stroke for thousands years. However, its mechanism action unclear. After cerebral ischemia, promoting angiogenesis after ischemia providing nutrition infarct area strategy improve damage ischemic area, but it also essential promote...
Abstract Small‐diameter vascular grafts (inner diameter < 6 mm) are useful in treating cardiovascular diseases. The off‐the‐shelf small‐diameter for clinical applications remain a great limitation owing to their thrombogenicity or intimal hyperplasia. Herein, bilayer anticoagulant hydrogel tubes with poly( ε ‐caprolactone) (PCL) sheaths prepared by freeze‐thawing and electrospinning, which contain nanofibrillated cellulose (NFC)/poly(vinyl alcohol) (PVA)‐heparin/poly‐ L ‐lysine...
Heterosis and polyploidy have an overwhelming influence on plant evolution. Recently, polyploid rice hybrids been used to breed new varieties because they combine the advantages of both heterosis polyploidy. In this study, we generated six lines: autotetraploid their parents, diploid donors, donors. To investigate molecular mechanism controlling effects hybridization polyploidization, performed bisulfite RNA sequencing young panicles at pollen meiosis stage compare DNA metabolomes...
Plant polyploidization is frequently associated with changes in nutrient contents. However, the possible contribution of metabolites to this change has not been investigated by characterizing metabolite contents diploid and tetraploid forms rice (Oryza sativa L.). We compared a group diploid-tetraploid japonica brown indica based on liquid chromatography-tandem mass spectrometry. In total, 401 were identified; these, between two groups, 180 showed opposite expression trends, but 221 same...
Little is known about transcriptional regulators of UDP-glucuronosyltransferase 2B10 (UGT2B10), an enzyme to glucuronidate many chemicals and drugs such as nicotine tricyclic antidepressants. Here, we uncovered that UGT2B10 was transcriptionally regulated by farnesoid X receptor (FXR), the bile acid sensing nuclear receptor. GW4064 chenodeoxycholic (two specific FXR agonists) treatment HepG2 cells led a significant increase in mRNA level UGT2B10. The treated also showed enhanced...
Abstract: Arenobufagin (ABG) is a major active component of toad venom, traditional Chinese medicine used for cancer therapy. However, poor aqueous solubility limits its pharmacological studies in vivo due to administration difficulties. In this study, we aimed develop polymeric nanomicelle (PN) system enhance the ABG effective intravenous delivery. ABG-loaded PNs (ABG-PNs) were prepared with methoxy poly (ethylene glycol)-block-poly (D,L-lactic-co-glycolic acid) (mPEG-PLGA) using...
This paper reports a new synthesis method to control the size of iron oxide nanoparticles (IONs) by adding sodium citrate during fabrication obtain citrate-modified (SCIONs).
Background: Contrast-enhanced magnetic resonance imaging (MRI) is a powerful diagnostic tool for many diseases. In situations, the contrasts are repeatedly administrated in order to monitor and assess disease progression. Objective: To investigate compare biological effects of γ-Fe 2 O 3 nanoparticle (NP) gadolinium dimeglumine (Gd-DTPA) with high multiple doses on kidney healthy mice. Methods: Polydextrose sorbitol carboxymethyl ether coated NP hydrodynamic size 68.2 nm clinically applied...
To explore the characteristics and influenced factors associated with onset of vertigo disease, analysis 3 719 cases hospitalized patients disease from real world. Analysis date diagnosed hospital information system 19 grade-III class-A 2004 to 2011, include general information, doctor's advice, other diseases combined, diagnostic relationship 24 solar terms, treatment drugs. The median age was 59, number women (65.91%) more than men (34.09%), manual workers (85.32%) were majority career,...
The pathological features of cerebral edema are complicated. intracranial pressure (ICP) is regarded as the most important indicator for monitoring edema. Recently, multi-parameter has been used to explore types and pathogenesis design effective treatment strategies. This research focused on investigating characteristic induced by lipopolysaccharide (LPS) in rats using simultaneous electrophysical hemodynamic parameters. results showed that neurophysiologic parameters (firing rate (FR) power...
Cellular drug response (concentration required for obtaining 50% of a maximum cellular effect, EC50) can be predicted by the intracellular bioavailability (Fic) and biochemical activity (half-maximal inhibitory concentration, IC50) drugs. In an ideal model, negative log EC50 (pEC50) equals sum Fic IC50 (pIC50). Here, we measured Fic's remdesivir, favipiravir, hydroxychloroquine in various cells calculated their anti-SARS-CoV-2 EC50's. The EC50's are close to observed vitro. When lung...
Objective To study the antifungal activities of triterpene glycosides derived from sea cucumber Actinopyga sp.Methods Triterpene were isolated and purified by silica gel chromatography,reversed-phase chromatography,Sephadex LH-20,and RP-HPLC sp.The structures elucidated based on spectral data,chemical reactions,and related references.The extracts against three strains:Candida albicans,Cryptococcus neoformans,and Aspergillus fumigatus assessed liquid microdilution method.Results Four...
Abstract Background : Plant polyploidization is frequently associated with changes in nutrient contents. However, the possible contribution of metabolites to this change has not been investigated by characterizing metabolite contents diploid and tetraploid forms rice ( Oryza sativa L.). Results We compared a group diploid–tetraploid japonica brown indica based on liquid chromatography-tandem mass spectrometry. In total, 401 differential expression were identified between diploids...