A5100344263- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Receptor Mechanisms and Signaling
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Health and Risk Factors
- Lipid metabolism and disorders
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- Ion Transport and Channel Regulation
- Cardiac Health and Mental Health
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
Shanghai Pulmonary Hospital
2021-2023
Tongji University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Dalian Medical University
2023
Army Medical University
2022-2023
Chongqing Medical University
2023
First Affiliated Hospital of Jinan University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Beijing Tongren Hospital
2020-2022
Beijing Center for Disease Prevention and Control
2022
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is characterized by progressive degeneration of the myocardium, arrhythmias, fibrous-fatty replacement, and increased risk sudden death. Mutations in 6 genes, including 4 encoding desmosomal proteins (Junctional plakoglobin (JUP), Desmoplakin (DSP), Plakophilin 2, Desmoglein 2), have been identified patients with ARVD/C. Mutation analysis 66 probands variants DSP; V30M, Q90R, W233X, R2834H. To establish a cause effect...
Matrix metalloproteinase (MMP) activation contributes to tissue remodeling in several disease states, and increased MMP activity has been observed left ventricular (LV) failure. The present study tested the hypothesis that inhibition would influence LV function developing failure.LV size were measured 5 groups of rats: (1) obese male spontaneously hypertensive heart failure rats (SHHF) at 9 months (n=10), (2) SHHF 13 (n=12), (3) treated with an inhibitor during (PD166793 mg. kg(-1). d(-1)...
This study tested the hypothesis that early routine use of tranexamic acid (TXA) reduces mortality in a subset most critically injured trauma intensive care unit patients.Consecutive patients (n = 1,217) who required emergency surgery (OR) and/or transfusions from August 2009 to January 2013 were reviewed. At surgeon discretion, TXA was administered at median 97 minutes (1-g bolus then 1-g over 8 hours) 150 deemed high risk for hemorrhagic death. With propensity scores based on age, sex,...
Background —Long-QT syndrome (LQTS) is an inherited cardiac arrhythmia that causes sudden death in young, otherwise healthy people. Four genes for LQTS have been mapped to chromosome 11p15.5 ( LQT1 ), 7q35–36 LQT2 3p21–24 LQT3 and 4q25–27 LQT4 ). Genes responsible , identified as potassium channel KVLQT1 HERG ) the sodium gene SCN5A Methods Results —After studying 115 families with LQTS, we used single-strand conformation polymorphism (SSCP) DNA sequence analysis identify mutations gene, ....
ABSTRACT The sinoatrial node (SAN), the primary cardiac pacemaker, consists of a head domain and junction/tail that exhibit different functional properties. However, underlying molecular mechanism defining these two pacemaker domains remains elusive. Nkx2-5 is key transcription factor essential for formation working myocardium, but it was generally thought to be detrimental SAN development. expressed in developing junction, suggesting role junction development function. In this study, we...
Abstract Hand, foot, and mouth disease (HFMD) is an infectious that usually occurs in children under 5 years caused by a group of enteroviruses. This study aimed to investigate the epidemiological characteristics HFMD clusters from 2016 2020 Tongzhou, Beijing, explored genetic evolution CV‐A6. The case information came Information System China Center for Disease Control Prevention (CDC), as well verification on‐site investigation Tongzhou CDC. ARIMA model was applied forecast 2020. Totally...
BACKGROUND:This study aimed to clarify the protective role of dexmedetomidine in thoracoscopic-assisted thoracic surgery (TATS), including control intraoperative heart rate, blood pressure, and myocardial injury markers. MATERIAL AND METHODS:The patients who underwent TATS were divided into 2 equal groups: group (dexmedetomidine pumped at 0.5 µg/kg for >10 min before administration anesthesia maintenance period) (pumped normal saline anesthesia). The data recorded each patient rate...
Abstract Objectives.—To describe the state of art our understanding long QT syndromes and to provide genetic correlation clinical severity patients with this disorder. Date Sources.—In review, we outline data that were obtained from work in laboratory, as well information reported literature. Study Selection.—The review spans last decade; studies had most impact, recent at laboratory. Data Extraction.—The herein extracted world literature on sudden death aspects syndrome. The genes...
Angiopoietin-like protein 2 (ANGPTL2), a member of the glycoprotein family, is mainly secreted by adipose tissues under normal conditions. Recently, ANGPTL2 has been found to be upregulated in some types cancers and considered tumor promoter. However, functional significance glioma not yet elucidated. In this study, we investigated specific role glioma. The results showed that was highly expressed cell lines. Knockdown reduced proliferative invasive abilities cells. Moreover, tumorigenesis...
Enterovirus 71 (EV71) is one of the causative agents hand, foot and mouth disease, which mostly affects infants children leads to severe neurological diseases. Vaccination offers best option for disease control. We have screened virus strain FY-23 K-B, used as an inactivated vaccine strain. An important issue in development vaccines whether they provide cross protection against all other strains.We collected identified 19 clinical EV71 isolates from mainland China, belong C4 genotype....
Enterovirus 71 (EV-A71) and Coxsackievirus A16 (CV-A16) are the two most common pathogens causing hand, foot, mouth disease (HFMD). Previously, we obtained one candidate live attenuated strain each for EV-A71 CV-A16; here, evaluated safety immunogenicity of a combinedlive vaccine against CV-A16 generated from these strains. Rhesus monkeys were intramuscularly treated with combinationvaccine both or either alone. No fever atypical clinical signs observed in any animals. Monkeys vaccinated...
Abstract Background Primary cardiac tumors are rare, and myxoma (CM) accounts for the majority of these tumors. Most reports in literature case reports. This study summarizes our clinical experience surgical treatment CM over past 12 years. Methods We retrospectively analyzed data 23 children with CM(8 boys, 15 girls; median age: 8.92 months, range: 2 years 5 months-12 9 months; body weight: 11-45 kg, 28.21 kg) admitted to hospital previous years, we statistically their manifestations...
Abstract Objectives.—To describe the state of art our understanding long QT syndromes and to provide genetic correlation clinical severity patients with this disorder. Date Sources.—In review, we outline data that were obtained from work in laboratory, as well information reported literature. Study Selection.—The review spans last decade; studies had most impact, recent at laboratory. Data Extraction.—The herein extracted world literature on sudden death aspects syndrome. The genes...
Introduction Preliminary evidence from clinical observations suggests that Tai Chi exercise may offer potential benefits for patients with chronic coronary syndrom (CCS). However, the advantages CCS to practice as rehabilitation have not been rigorously tested and there is a lack of consensus on its benefits. This study aims develop an innovative Cardiac Rehabilitation Program (TCCRP) assess efficacy, safety acceptability programme. Methods analysis We propose conduct multicentre randomised...