A5101821427- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- T-cell and Retrovirus Studies
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Ovarian function and disorders
- RNA Research and Splicing
- Photoreceptor and optogenetics research
- Kruppel-like factors research
- Genetics and Neurodevelopmental Disorders
- Probiotics and Fermented Foods
- RNA regulation and disease
- Viral Infections and Immunology Research
- Nuclear Receptors and Signaling
- Retinal Development and Disorders
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- RNA modifications and cancer
- Adipose Tissue and Metabolism
- Insect Resistance and Genetics
- Endoplasmic Reticulum Stress and Disease
Yangzhou University
2022-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shandong Agricultural University
2024
University of California, Los Angeles
2023
University of Southern California
2023
University of California, Irvine
2023
Southern California University for Professional Studies
2023
Huazhong Agricultural University
2023
Obstetrics and Gynecology Hospital of Fudan University
2021
Hair morphogenesis is tightly related to hair follicle stem cells (HFSCs) proliferation and (HF) development. Yangtze River Delta white goats (YRDWG) HFSCs are important for producing superior-quality brush (SQBH). Nonetheless, the known regulatory mechanisms not sufficient explain YRDWG gHFSCs growth, HF development, SQBH formation. To deeply investigate interaction networks of circCOL1A1 in development formation detail, we applied whole-transcriptome sequencing bioinformatics analysis...
Retinitis pigmentosa (RP) is an ocular disease characterized by the loss of night vision, followed daylight vision. Daylight vision initiated in retina cone photoreceptors, which are gradually lost RP, often as bystanders a process that initiates their neighboring rod photoreceptors. Using physiological assays, we investigated timing electroretinogram (ERG) decline RP mouse models. A correlation between time ERG and rods was found. To investigate potential role visual chromophore supply this...
Circular RNAs (circRNAs) are a novel type of non-coding RNA expressed across different species and tissues. At present, little is known about the expression function circRNAs in tree shrew brain. In this study, we used RNA-seq to identify 35,007 hippocampus cerebellum samples from infant (aged 47-52 days), young 15-18 months), old 78-86 months) shrews. We observed no significant changes total circRNA profiles brain regions over time. However, tended be downregulated Real-time RT-PCR analysis...
Abstract Background Several studies have shown the crucial role of miR-501 in regulating cellular pathology various cancers. However, function and expression endometrial cancer (EC) remain obscure. Methods The was determined using quantitative real-time PCR. MTT assay, colony formation assay cell cycle analysis were used to evaluate proliferation ability. Migration invasion assessed transwell assay. Tumor nude mice observe effects on migration vivo. Luciferase PCR western blot applied...
Microbiota are known to modulate the host response influenza infection, but mechanisms remain largely unknown. Gut metabolites key mediators through which gut microbes play anti-influenza effect. Transferring fecal from mice with high resistance into antibiotic-treated recipient conferred infections. By comparing of different individuals or low resistance, we identified and validated N-acetyl-D-glucosamine (GlcNAc) adenosine showed strong positive correlations exerted effects in vivo vitro,...
Superior-quality brush hair, also called Type III can be obtained only from the cervical spine region of skin tissues Yangtze River Delta white goats. The formation superior-quality hair is controlled by a series critical genes and related signaling pathways. Circular RNAs (circRNAs) are ubiquitous endogenous noncoding that regulate many biological physiological processes in mammals. However, little known about potential regulatory role circRNAs formation. Here, we analyzed circRNA...
Epigenetic was identified to closely related nasal polyp formation in CRSwNP before 18 years ago,epigenetic modifications have gained more attention from researchers owing their importance role the pathogenesis of and potential biomarkers for diagnosis treatment. As regulators, epigenetic (including ncRNA, histone modification DNA methylation) participate inflammation remodeling processes by different signaling pathways through affecting gene expression. In this review, we conclude changes ,...
Abstract Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding that play an important role in growth and development by regulating gene expression participating variety biological processes. However, the circRNAs porcine follicles remains unclear. Therefore, this study examined middle-sized ovarian obtained from Meishan Duroc sows at day 4 follicular phase. High-throughput RNA sequencing (RNA-seq) was utilized to construct circRNAs, differential identified. The...
As the master regulator of adipogenesis, peroxisome proliferator-activated receptor gamma (PPARG) is required for accumulation adipose tissue and hence contributes to obesity. A previous study showed that substitution +20A>G in PPARG changed 7th amino acid from Asp Gly, creating a mutant referred as Asp7Gly. In this study, association analysis indicated Asp7Gly was associated with lower body height, weight heart girth cattle (P<0.05). Overexpression NIH3T3-L1 cells may cause decrease its...