A5050988890- Natural product bioactivities and synthesis
- Pain Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Plant-based Medicinal Research
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Berberine and alkaloids research
- Cancer therapeutics and mechanisms
- Innovations in Medical Education
- Cultural Competency in Health Care
- Chromatography in Natural Products
- Infant Nutrition and Health
- Synthesis and bioactivity of alkaloids
- Advanced Chemical Sensor Technologies
- Inflammasome and immune disorders
- Insect Pheromone Research and Control
- Global Health and Surgery
- Systemic Sclerosis and Related Diseases
- Phytochemicals and Antioxidant Activities
- Protein Hydrolysis and Bioactive Peptides
- Lymphoma Diagnosis and Treatment
- Nerve injury and regeneration
- Traditional Chinese Medicine Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Tianjin Hospital
2024
Jinzhou Medical University
2024
Xiyuan Hospital
2023-2024
Tianjin University
2024
Nanjing University of Chinese Medicine
2024
Chongqing University of Arts and Sciences
2024
Tianjin Medical University Cancer Institute and Hospital
2024
Peking Union Medical College Hospital
2013-2023
North China University of Science and Technology
2023
Diabetic peripheral neuropathy (DPN) is a prevalent complication of diabetes with no effective drug currently. As powerful antioxidant, the flavonoid quercetin has been demonstrated to have potential neuroprotective and prebiotic capacity. But mechanism its function link gut microbiota remains be elucidated. The effect was evaluated on streptozotocin(STZ)-induced DPN rats through electrophysiology, behavioristic, pathomorphology studies. Serum urine reactive oxygen species (ROS) production...
Abstract A phenylethanoid‐rich extract (ECD) of Cistanche deserticola Y.C. Ma, a holoparasitic plant and valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) administered orally to mice 3 weeks. The swimming time exhaustion longer the treatment groups (0.50, than control group ( p < 0.01). serum creatine kinase, lactate dehydrogenase lactic acid levels were decreased significantly compared with group, while contents...
Human and animal milk contains a rich variety of oligosaccharides (OSs), which are great interest due to similar biological efficacy. In this study, the OSs were identified concentrations eight specific in human four (cow, goat, sheep, camel) analyzed. general, 30, 42, 32, 34, 35 bovine, caprine, ovine, camel, milk, respectively. Camel was most type than other milk. The concentration approximately six times higher that camel 20 bovine caprine 75 ovine Collectively, these findings revealed...
The aim of this study was to investigate the changes in human and animal milk oligosaccharides over lactation. In total, 89, 97, 115, 71 were identified human, bovine, goat, camel milk. number common between highest (16 17 transitional mature milk). With respect absolute concentration eight (2'-FL, 3-FL, α3'-GL, LNT, LNnT, 3'-SL, 6'-SL, DSL), 2'-FL, 3'-FL, LNnT much higher than three species. 3'-SL had a similar bovine colostrum (322.2 μg/mL) (321.0 μg/mL), followed by goat (105.1 μg/mL);...
Biflavonoids, a special class of flavonoids, are widely distributed in gymnosperm plants and have various biological activities. They also major bioactive ingredients Selaginella tamariscina. In this work, we report the use high-performance liquid chromatography with diode-array detector (HPLC-DAD) electrospray ionization multi-stage tandem mass spectrometry (ESI-MS(n)) to study fragmentation behavior three main types biflavonoids using seven biflavonoid reference compounds analyze The most...
Background This study aims to investigate the relationship between blood urea nitrogen serum albumin ratio (BAR) and all-cause mortality in patients with acute kidney injury (AKI) evaluate effect of BAR on prognosis AKI. Methods Adult AKI admitted ICU Medical Information Mart for Intensive Care IV (MIMIC-IV) were selected a retrospective cohort study. (mg/g) was calculated using initial (mg/dl)/serum (g/dl). According BAR, these divided into quartiles (Q1–Q4). Kaplan–Meier analysis used...
Jinmaitong (JMT) has been used to prevent and treat diabetic peripheral neuropathy (DPN) for decades. The present study aimed elucidate the effects of JMT on thioredoxin-interacting protein (TXNIP) Nod-like receptor 3 (NLRP3) inflammasome activation in streptozotocin (STZ)-induced rat model.The model was induced by a single intraperitoneal injection 55 mg/kg STZ. rats were divided into groups (n = 8-10 per group): control, (0.876 g/kg/d), alpha-lipoic acid (ALA; 100 mg/kg/d). Body weight...
GTSE1 is well correlated with tumor progression; however, little known regarding its role in liver cancer prognosis. By analyzing the hepatocellular carcinoma (HCC) datasets GEO and TCGA databases, we showed that high expression of was advanced pathologic stage poor prognosis HCC patients. To investigate underlying molecular mechanism, generated knockdown cell line explored effects deficiency growth. Between wild-type cells, identified 979 differentially expressed genes (520 downregulated...
This article studies whether or not health education programs targeting childhood anemia are sufficient for changing behavior and nutrition in rural China. We conducted three different randomized-controlled trials of single multiple face-to-face sessions with parents distributed written materials—and compare our results a simple vitamin distribution program. Across all studies, we find little evidence changes blood hemoglobin concentration status. In contrast, two that also examined...
Intestinal bacteria have a significant role in metabolism and the pharmacologic actions of traditional Chinese medicine active ingredients. Phenylethanoid glycosides (PhGs), as typical phenolic natural products, possess wide bioactivities, but low oral bioavailability. The aim this work was to elucidate metabolic mechanism underlying PhGs intestinal tract screen for more metabolites. In study, rapid reliable method using an effective post-acquisition approach based on advanced...
Shengjiang Xiexin decoction (SXD), a classic traditional Chinese medical formula chronicled in Shang Han Lun, is used modern clinical practice to decrease gastrointestinal toxicity induced by the chemotherapeutic drug irinotecan (CPT-11). In this study, effect of SXD on pharmacokinetics CPT-11 and its active metabolites (SN-38 SN-38G), underlying mechanisms were further examined. An ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed...