A5101894560- Pain Mechanisms and Treatments
- Phytochemistry and biological activities of Ficus species
- Nerve injury and regeneration
- Calpain Protease Function and Regulation
- Ginger and Zingiberaceae research
- Pharmacological Effects of Natural Compounds
- Berberine and alkaloids research
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Bee Products Chemical Analysis
- Fungal Biology and Applications
- Plant-based Medicinal Research
- Plant Virus Research Studies
- Traditional Chinese Medicine Analysis
- Axon Guidance and Neuronal Signaling
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Healthcare and Venom Research
- Inflammasome and immune disorders
- Neuroendocrine Tumor Research Advances
- Neurological Disorders and Treatments
- Plant-Microbe Interactions and Immunity
- Flavonoids in Medical Research
- Sirtuins and Resveratrol in Medicine
- Mangiferin and Mango Extracts
- Vitamin K Research Studies
Peking Union Medical College Hospital
2008-2024
Ningxia Academy of Agriculture and Forestry Sciences
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2024
Shandong Academy of Agricultural Sciences
2016-2023
Institute of Zoology
2023
Guangdong Academy of Sciences
2023
Sun Yat-sen University
2018-2020
Chinese Academy of Tropical Agricultural Sciences
2019
Ministry of Agriculture and Rural Affairs
2019
Chinese PLA General Hospital
2011-2012
Quercetin can reverse high glucose-induced inhibition of neural cell proliferation, and therefore may have a neuroprotective effect in diabetic peripheral neuropathy. It is difficult to obtain primary Schwann cells RSC96 could replace studies the role autophagy mechanism underlying Here, we show that under glucose conditions, there are fewer autophagosomes immortalized rat than control proliferative activity both types significantly impaired, expression Beclin-1 LC3, molecular markers for...
OBJECTIVE This study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi [SZ-A]) in treatment type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS was a multicenter, randomized, double-blind, double-dummy, parallel controlled noninferiority clinical trial that conducted for 24 weeks. A total 600 patients were randomly allocated SZ-A group (n = 360) or acarbose 240). The primary end point change glycosylated hemoglobin (HbA1c) compared with baseline. In addition,...
Jinmaitong (JMT) has been used to prevent and treat diabetic peripheral neuropathy (DPN) for decades. The present study aimed elucidate the effects of JMT on thioredoxin-interacting protein (TXNIP) Nod-like receptor 3 (NLRP3) inflammasome activation in streptozotocin (STZ)-induced rat model.The model was induced by a single intraperitoneal injection 55 mg/kg STZ. rats were divided into groups (n = 8-10 per group): control, (0.876 g/kg/d), alpha-lipoic acid (ALA; 100 mg/kg/d). Body weight...
Bacterial wilt caused by the bacterial pathogen Ralstonia solanacearum is one of most devastating crop diseases worldwide. The molecular mechanisms controlling early stage R. colonization in root remain unknown. Aiming to better understand mechanism establishment infection root, we established four stages interaction with Arabidopsis roots and determined transcriptional profiles these infection. A total 2,698 genes were identified as differentially expressed during initial 96 h after...
Jinmaitong (JMT) is a Traditional Chinese Compound Prescription for the treatment of diabetic peripheral neuropathy (DPN). This study aims to investigate effect JMT on insulin-like growth factor 1 (IGF-1) and insulin like receptor (IGF-1R) expression in sciatic nerves rats. Firstly, chemical profile was characterized by UPLC/Q-TOF-MS analysis. A total 72 compounds were putatively identified. Secondly, streptozotocin (STZ)-induced rats treated with neurotropin (NTP, 2.67 NU/kg/day) or at...
To assess the accuracy of combined preoperative localizations and analyze change in management strategy operation insulinoma.One hundred seventy-two patients with a diagnosis insulinoma at tertiary hospital between 1985 2010 were reviewed, where accurate localization before surgical exploration was primary policy insulinoma. Operation details for 147 checked.An average 2.89 studies including 1.61 non-invasive 1.28 invasive utilized per patient. Contrast-enhanced ultrasonography (CEUS) most...
Introduction The root-knot nematodes (RKN), especially Meloidogyne spp., are globally emerging harmful animals for many agricultural crops. Methods To explore microbial agents biological control of these nematodes, the communities rhizosphere soils and roots sponge gourd ( Luffa cylindrica ) infected non-infected by M. incognita were investigated using culture-dependent -independent methods. Results Thirty-two culturable bacterial eight fungal species, along with 10,561 2,427 operational...
Chinese Artichoke ( Stachys sieboldii Miq.), an indigenous vegetable in China, is renowned for its rich nutritional content and medicinal properties. With a significant cultivation history promising prospects, this holds great potential further development. In study, we investigated changes gene expression levels metabolite within relevant metabolic pathways during the development of tubers. Tubers from three different periods—S1 (6 Aug), S2 (2 Sep), S3 (1 Oct)—served as materials analysis....
One of the major variables affecting yield mushroom Agaricus bisporus is casing layer, which directly affects productivity and mass. Here, volatile organic compounds were extracted by headspace solid-phase microextraction high-throughput sequencing was used to analyze microbial community diversity. The relationship between at different cropping stages contents microorganisms in three layers: peat, peat + soil systematically evaluated. result shows that Benzaldehyde (E)-2-octenal stimulate...
Abstract The objective of this study was to investigate the effects single nucleotide polymorphisms (SNPs) in nine candidate genes on meat quality traits longissimus dorsi muscle pigs. Each SNP allele's main were as follows: ADRB3 c. 1192G allele increased intramuscular fat (IMF; p<0.01) and yellowness (p<0.05). MC4R 745G body weight LEPR 232T rib eye area decreased tenderness HSL 873G IMF backfat thickness LPL 74T IMF, tenderness, MYF5 1205A improved H-FABP 1322T PPARγ 175G water loss...
Protein kinase D 1 (PKD1) is a serine/threonine implicated in the regulation of diverse cellular functions including cell growth, differentiation, adhesion and motility. The current model for PKD1 activation involves diacylglycerol (DAG) binding to C1 domain which results translocation subcellular membranes where phosphorylated activated by protein C (PKC). In this study, we have identified novel activation. epithelial membrane E-cadherin physically binds leads redistribution PKD1....