A5029775146- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Berberine and alkaloids research
- Diet, Metabolism, and Disease
- Natural Antidiabetic Agents Studies
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Gut microbiota and health
- Biochemical and Molecular Research
- Biochemical Analysis and Sensing Techniques
- Drug Transport and Resistance Mechanisms
- Receptor Mechanisms and Signaling
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Phytochemistry and biological activities of Ficus species
- Helicobacter pylori-related gastroenterology studies
- Ginger and Zingiberaceae research
- Aldose Reductase and Taurine
- Regulation of Appetite and Obesity
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Henan University
2024
Peking Union Medical College Hospital
2005-2018
Texas A&M University
1992
Chronic glucocorticoid therapy has serious side effects, including diabetes and fatty liver. However, the molecular mechanisms responsible for steroid-induced remain largely enigmatic. Here, we show that hepatic Krüppel-like factor 9 (Klf9) gene expression is induced by dexamethasone fasting. The overexpression of Klf9 in primary hepatocytes strongly stimulated Pgc1a through direct binding to its promoter, thereby activating gluconeogenic program. mutation abolished stimulatory effect on...
OBJECTIVE This study aimed to evaluate the efficacy and safety of mulberry twig alkaloids (Sangzhi [SZ-A]) in treatment type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS was a multicenter, randomized, double-blind, double-dummy, parallel controlled noninferiority clinical trial that conducted for 24 weeks. A total 600 patients were randomly allocated SZ-A group (n = 360) or acarbose 240). The primary end point change glycosylated hemoglobin (HbA1c) compared with baseline. In addition,...
Nonalcoholic fatty liver disease (NAFLD), obesity, and type 2 diabetes mellitus (T2DM) have highly related mechanisms. Ramulus Mori (Sangzhi) alkaloids (SZ-A) from Morus alba L. were approved in 2020 for the treatment of T2DM. In this study, we examined therapeutic effects mechanism SZ-A on obesity NAFLD mice. Mice (C57BL/6J) fed a high-fat diet (HFD) 14 weeks treated with another 6 weeks. HFD-induced weight gain was reduced by dose-dependent manner. significantly stimulated adiponectin...
Berberine (BBR), a small alkaloid, is used as hypoglycemic agent in China. Stachyose (Sta), Rehmannia glutinosa oligosaccharide, acts prebiotic. This study aimed to evaluate whether BBR combined with Sta produced better glycometabolism than alone, and explored the effects on gut microbiota metabolomics. Type-2 diabetic db/db mice were administered (100 mg/kg), (200 or both by gavage once daily. Glucose metabolism, balance of α- β-cells, mucin-2 expression ameliorated treatment Sta, stronger...
The novel Traditional Chinese Medicine Ramulus Mori (Sangzhi) alkaloid tablets (SZ-A) are approved by China National Medical Products Administration for the treatment of type 2 diabetes mellitus (T2DM). However, extensive pharmacological characteristics and underlying mechanism unknown. This study investigated mechanisms which SZ-A ameliorates glucose metabolism in KKAy mice, an animal model T2DM. Diabetic mice were treated intragastrically with once daily 8 weeks, after levels, lipid...
α-glucosidase inhibitors (AGIs) have been an important category of oral antidiabetic drugs being widely exploited for the effective management type 2 diabetes mellitus. However, marketed AGIs not only inhibited disaccharidases, but also exhibited excessive inhibitory effect on α-amylase, resulting in undesirable gastrointestinal side effects. Compared to these agents, Ramulus Mori alkaloids (SZ-A), was a group from natural Morus alba L., and showed excellent hypoglycemic fewer effects Phase...
Berberine (BBR) has the beneficial effects of anti-inflammation, anti-bacteria, and anti-diabetes. The clinical application BBR been hindered by its poor gastrointestinal absorption. Stachyose (Sta), a prebiotic agent, improves composition gut microbiota benefits for diabetes. We therefore investigated whether Sta anti-diabetic actions using KKAy mice. Here, we find that combination is more effective than alone in blood glucose control, improvement insulin resistance islet functions,...
Background:Morus alba L. (Sangzhi) alkaloids (SZ-A), extracted from the Chinese herb Morus (mulberry twig), have been shown to ameliorate hyperglycemia in type 2 diabetes and approved for treatment clinic. However, their versatile pharmacologic effects regulatory mechanisms are not yet completely understood. Purpose: This study explored protective of SZ-A on islet β cells underlying mechanism. Methods: Type diabetic KKAy mice were orally administered (100 or 200 mg/kg, once daily) 11 weeks,...
The aim of this study was to investigate the capacity chiglitazar improve insulin resistance and dyslipidemia in monosodium L ‐glutamate (MSG) obese rats determine whether its lipid‐lowering effect is mediated through activation PPAR α . Chiglitazar a / γ dual agonist. compound improved impaired glucose tolerance; decreased plasma level increased sensitivity index HOMA index. Euglycemic hyperinsulinemic clamp studies showed infusion rate MSG rats. inhibited alanine gluconeogenesis, lowered...
Solid rationales are still present for the identification of synthetic ligands to simultaneously target multiple PPAR subtypes treatment T2DM. The purpose this study was characterize in vitro and vivo differential effects chiglitazar, a non-TZD type pan-agonist currently phase III clinic development China, from γ -selective agonist like rosiglitazone. Chiglitazar showed transactivating activity each α , δ subtype upregulated expression and/or downstream genes involved key processes lipid...
Three novel sesquinlignans, tatanans A (1), B (2), and C (3), have been isolated from the rhizomes of Acorus tatarinowii Schott. Their structures were established by spectroscopic techniques single-crystal X-ray analysis. Tatanans A−C potently increase GK enzymatic activity with EC1.5 values in range 0.16−1.85 μM. The potent unique structural features make them promising leads for therapeutic development antihyperglycemic drugs.
3-Hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase inhibitors or statins are competitive of the rate-limiting enzyme in cholesterol biosynthesis. Currently, used as first-line therapy treatment diabetic dyslipidemia. However, effects on β cell function remains unclear. This study aims to examine atorvastatin pancreatic obese C57BL/6 J mice and possible mechanisms. Diet-induced obesity (DIO) were treated with (30 mg/kg/day) for 58 days. was assessed by hyperglycemic clamp area...
Refined-JQ (JQ-R) is a mixture of refined extracts from Coptis chinensis (Ranunculaceae), Astragalus membranaceus (Leguminosae) and Lonicera japonica (Caprifoliaceae), the three major herbs JinQi-JiangTang tablet, traditional Chinese medicine (TCM) formula. The mechanisms by which JQ-R regulates glucose metabolism improves insulin sensitivity were studied in type 2 diabetic KKAy mice insulin-resistant L6 myotubes. To investigate sensitivity, model cells induced with palmitic acid (PA) was...
Six new triterpenoids including four secodammarane triterpenoid glycosides (1–4), an epoxydammarane glycoside (5), and a (6) were isolated from the ethanolic extract of leaves Cyclocarya paliurus. The structures these compounds elucidated by spectroscopic analysis methods. Compounds 1–6 evaluated for their inhibitory activities against α-glucosidase, lipase, DPP-IV, aldose reductase.
Abstract Background Fenofibrate, a PPAR alpha agonist, has been widely used in clinics as lipid-regulating agent. is known to be expressed many organs including pancreatic beta cells and regulate genes involved fatty acid metabolism. Some reports based on cell lines or animals have provided evidences that agonists may affect (increased suppressed) insulin secretion, several studies are producing interesting but still debated results. Methods In this research, we investigated the long term...