A5100455428- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Parkinson's Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Traditional Chinese Medicine Analysis
- Plant-based Medicinal Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Syphilis Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Intracranial Aneurysms: Treatment and Complications
- Restless Legs Syndrome Research
- Traditional Chinese Medicine Studies
- Acute Myeloid Leukemia Research
- Vascular Malformations Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Medicinal Plant Pharmacodynamics Research
- Cardiovascular Syncope and Autonomic Disorders
- Brain Metastases and Treatment
- Ginkgo biloba and Cashew Applications
Yancheng First People's Hospital
2025
Nantong University
2025
Wannan Medical College
2025
First Affiliated Hospital of Wannan Medical College
2025
Peking University First Hospital
2022-2024
Peking University
2022-2024
Capital Medical University
2013-2024
Qingdao Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Ningxia Medical University
2024
Xanthine oxidase (XO), a key enzyme in purine catabolism, is widely distributed human tissues. It can catalyze xanthine to generate uric acid and cause hyperuricemia gout. Inhibition kinetics assay showed that kaempferol inhibited XO activity reversibly competitive manner. Strong fluorescence quenching conformational changes of were found due the formation kaempferol-XO complex, which was driven mainly by hydrophobic forces. The molecular docking further revealed inserted into cavity...
Chemoresistance is one of the major causes therapeutic failure and poor prognosis for breast cancer patients, especially triple-negative patients. However, underlying mechanism remains elusive. Here, we identified novel functional roles heat shock protein beta-1 (HSPB1), regulating chemoresistance ferroptotic cell death in cancer. Based on TCGA GEO databases, HSPB1 expression was upregulated tissues associated with which considered an independent prognostic factor Functional assays revealed...
To investigate clinical features and potential mechanisms involving α-synuclein oligomer inflammation in patients with Parkinson disease (PD) probable REM sleep behavior disorder (PRBD).We used the Sleep Behavior Disorder Screening Questionnaire (RBDSQ) to evaluate PD classified each as PRBD or not (NPRBD). Data collection included demographic information evaluation of symptoms using a series rating scales. We tested for inflammatory factors CSF serum. analyses comparisons between NPRBD...
Cognitive impairment strikingly reduces the quality of life Parkinson's disease (PD) patients. Studies find that pathological proteins, neuroinflammatory factors and free radicals may involve in pathogenesis cognitive PD, however, results are inconclusive. We recruited 62 PD patients 31 healthy controls. were identified with impairment, including mild (PD-MCI) dementia (PDD) according to diagnostic criteria for PD-MCI PDD issued by Movement Disorder Society Task Force. The levels β-amyloid...
Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of involving serotonergic dysfunction abnormal iron metabolism are still unknown. Therefore, we evaluated the symptoms, classified PD patients into group non-fatigue group, detected levels serotonin, related proteins CSF serum. In CSF, 5-HT level significantly decreased transferrin dramatically increased group. score negatively correlated...
The mechanism of cuproptosis has recently been reported in lipoylated proteins the tricarboxylic acid (TCA) cycle. Besides, role copper was previously recognized cancer progression. We evaluated prognostic value cuproptosis-related gene expression hepatocellular carcinoma (HCC). Remarkable genes were selected both differential analysis and Kaplan-Meier survival from ninety-six using Cancer Genome Atlas (TCGA) database. relationships between clinical characteristics performed with Wilcoxon...
The cost and time to develop a drug continues be major barrier widespread distribution of medication. Although the genomic revolution appears have had little impact on this problem, might even exacerbated it because flood additional usually ineffective leads, emergence high throughput resources promises possibility rapid, reliable systematic identification approved drugs for originally unintended uses. In paper we apply method identifying such repositioned candidates against breast cancer,...
ABSTRACT Renal fibrosis (RF) is a crucial pathological factor in the progression of chronic kidney disease (CKD) to end‐stage renal failure, and accurate noninvasive assays monitor are needed. Circular RNAs (circRNAs) noncoding that can be used as diagnostic biomarkers therapeutic targets for human diseases. In this study, we analysed expression hsa_circ_0008925 urinary tubular cells investigated its role fibrosis. Urinary samples were collected from CKD patients with varying degrees...
Parkinson's disease (PD) is characterized by olfactory dysfunction (OD) and cognitive deficits at its early stages, yet the link between OD also not well-understood. This study aims to examine changes in network associated with their relationship function de novo PD patients. A total of 116 drug-naïve patients 51 healthy controls (HCs) were recruited for this study. Graph theoretical approaches employed reveal abnormalities topological characteristics network. Network-based statistics (NBS)...
Background Renal fibrosis is a hallmark of progressive chronic kidney disease (CKD), with emerging evidence linking gut microbiota dysbiosis to progression. Myeloid-derived suppressor cells (MDSCs) have demonstrated renoprotective effects, yet the impact fecal transplantation (FMT) on MDSC-mediated modulation renal remains unclear.
Ephrin type B receptor 4 (EphB4, Eph receptor) selectively binds ephrin B2 (Eph ligand). EphB4/ephrin is involved in embryonic vessel development, vascular remodelling and pathological formation adults (including tumour angiogenesis). Binding of endothelial growth factor (VEGF)-A to the endothelial-specific VEGF receptor-2 main extracellular signal triggering angiogenic response. Little known about role during angiogenesis arteriovenous plasticity cerebral malformation (cAVM). This study...