A5037258717- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Inflammation biomarkers and pathways
- Ovarian function and disorders
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
Anhui Medical University
2025
Shandong University
2006-2020
ABSTRACT Renal fibrosis (RF) is a crucial pathological factor in the progression of chronic kidney disease (CKD) to end‐stage renal failure, and accurate noninvasive assays monitor are needed. Circular RNAs (circRNAs) noncoding that can be used as diagnostic biomarkers therapeutic targets for human diseases. In this study, we analysed expression hsa_circ_0008925 urinary tubular cells investigated its role fibrosis. Urinary samples were collected from CKD patients with varying degrees...
Macrophages are recognized as vital players in renal fibrosis, with a high degree of heterogeneity and plasticity, the triggering receptor expressed on myeloid cell-2 (TREM-2) is highly macrophages participates progression tissue fibrosis. However, mechanism by which TREM-2 mediates fibrosis still unclear. Our study revealed that exosomes derived from TREM-2-deficient (TREM-2