Objective: We aimed to develop and validate a predictive machine learning (ML) model for cardiac surgery associated with acute kidney injury (CSA-AKI) based on multicenter randomized control trial (RCT) Medical Information Mart Intensive Care-IV (MIMIC-IV) dataset. Methods: This was subanalysis from completed RCT approved by the Ethics Committee of Fuwai Hospital in Beijing, China (NCT03782350). Data were randomly assigned, 80% training dataset 20% testing The data three other centers used...

Intestinal microbiota operated as a whole and was closely related with human health. Previous studies had suggested close relationship between liver cirrhosis (LC) gut microbiota.To determine the functional characteristic of intestinal specific for cirrhosis, fecal metaproteome three LC patients Child-Turcotte-Pugh (CTP) score A, B, C, their spouse were first compared using high-throughput approach based on denaturing polyacrylamide gel electrophoresis liquid chromatography-tandem mass...

Background: The potential myocardial protective effect of nicorandil (NICD) in patients undergoing percutaneous coronary intervention has been established. However, its efficacy the context cardiac surgery remains controversial. present study aimed to evaluate perioperative NICD use with cardiopulmonary bypass (CPB). Methods: We retrospectively gathered data from between 12/2018 and 04/2021 Fuwai Hospital. Subsequently, were divided into two groups, group non-nicorandil (non-NICD) group. A...

Abstract Background Perioperative myocardial injury (PMI) with different cut-off values has showed to be associated prognostic effect after cardiac surgery. Machine learning (ML) method been widely used in perioperative risk predictions during However, the utilization of ML PMI not studied yet. Therefore, we sought develop and validate performances for surgery cardiopulmonary bypass (CPB). Methods This was a second analysis multicenter clinical trial (OPTIMAL) requirement written informed...

Macrophages are recognized as vital players in renal fibrosis, with a high degree of heterogeneity and plasticity, the triggering receptor expressed on myeloid cell-2 (TREM-2) is highly macrophages participates progression tissue fibrosis. However, mechanism by which TREM-2 mediates fibrosis still unclear. Our study revealed that exosomes derived from TREM-2-deficient (TREM-2

Peripheral nerve block is often used to relieve postoperative pain. But the effect of on inflammatory response not fully understood. Spinal cord primary center pain processing. This study investigate single sciatic spinal in rats with plantar incision and combined flurbiprofen.The was establish a model. Single block, intravenous flurbiprofen or combination both were for intervention. The sensory motor functions after evaluated. changes IL-1β, IL-6, TNF-α, microglia astrocytes examined by...

Introduction: We sought to comprehensively explore the potential linear and nonlinear relationship between preoperative iron metabolism perioperative myocardial injury (PMI) following cardiac surgery with cardiopulmonary bypass (CPB). Methods: Patients who underwent CPB December 2018 April 2021 were retrospectively collected. The measurements of included serum (SI), ferritin (SF), transferrin (TRF), saturation (TS), total iron-binding capacity (TIBC). Logistic regression restricted cubic...

We sought to explore the linear or nonlinear relationship between preoperative iron metabolism and acute kidney injury following cardiac surgery (CSA-AKI) with cardiopulmonary bypass (CPB). Patients who underwent CPB December 2018 April 2021 were retrospectively collected from Fuwai Hospital Medical Information Mart for Intensive Cared dataset (MIMIC-IV). The measurements of included serum (SI), ferritin (SF), transferrin (TRF), saturation (TS), total binding capacity (TIBC). Logistic...

Background Perioperative myocardial injury (PMI) is associated with increased mobility and mortality after noncoronary cardiac surgery. However, limited studies have developed a predictive model for PMI. Therefore, we used hybrid feature selection (FS) methods to establish PMI in surgery cardiopulmonary bypass (CPB). Methods This was single-center retrospective study conducted at the Fuwai Hospital China. Patients aged 18-70 years who underwent elective CPB our institution from December 2018...

Objective The monocyte-to-lymphocyte multiplying platelets ratio (MLPR) is a novel systemic inflammatory marker, deriving from the (MLR). However, link between MLPR and acute kidney injury following cardiac surgery (CSA-AKI) with cardiopulmonary bypass (CPB) has not been investigated yet. We comprehensively explored potential linear nonlinear relationship or MLR CSA-AKI.

Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is related to increased morbidity and mortality. However, limited studies have explored the influence of different feature selection (FS) methods on predictive performance CSA-AKI. Therefore, we aimed compare impact FS for Methods CSA-AKI defined according disease: Improving Global Outcomes (KDIGO) criteria. Both traditional logistic regression machine learning were used select potential risk factors The area under receiver...

The meniscus plays a critical role in preserving the knee's normal physiological function, which includes proprioception, stabilising joint, nourishing and lubricating it, increasing contact area of articular surfaces match between tibia femur, bearing distributed stress shock. When people are exposed to external forces that cause their knees twist, injury may result. However, if is removed for resection, likelihood developing osteoarthritis knee joint increases. As arthroscopy technology...

Abstract Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is related to increased mobility and mortality. A large number of studies have explored the risk factors AKI using traditional logistic regression (LR), which requires a generalized linear relationship between covariates outcome. However, limited influence different feature selection (FS) methods on predictive performance CSA-AKI. Therefore, we aimed compare impact FS for Methods CSA-AKI defined according disease:...

Objective To guide fluid management for sever heart failure patients by using PICCO indicators, in order to direct clinical and nursing care. Methods Sixty- four with level IV cardiac function were randomly divided into the control group experimental according random number table, each one had 32 patients. Fluid was implemented CVP monitoring technology, while accepted technology as management. Then compare these indicators between two groups-- length of stay ICU, mortality rate 28...

Purpose: To determine the anti-tumor effects of Actinidia chinensis Planch (ACP) root extract as well its mechanism action against gastric cancer (GC) using network pharmacology.Methods: The bioactive compounds and targets ACP, GC-related genes were identified from a series public databases. Functional enrichment analysis was conducted to find relevant biological processes pathways. survival GEPIA tool. Autodock used carry out molecular docking between ingredients their targets.Results: A...

Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a complication related to increased mobility and mortality. Machine learning techniques have been emerging as novel prediction method; however, the influence of different feature selections (FS) on predictive performance risk factors for CSA-AKI remain unknown. Therefore, this study compared selection based machine with traditional logistic regression (LR) investigate CSA-AKI.Methods: A total 1977 patients undergoing...