A5036574404- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cardiovascular Disease and Adiposity
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Energy and Environment Impacts
- Cancer-related molecular mechanisms research
- Inflammation biomarkers and pathways
- HIV/AIDS drug development and treatment
- MicroRNA in disease regulation
Wannan Medical College
2022-2025
First Affiliated Hospital of Wannan Medical College
2022-2025
ABSTRACT Renal fibrosis (RF) is a crucial pathological factor in the progression of chronic kidney disease (CKD) to end‐stage renal failure, and accurate noninvasive assays monitor are needed. Circular RNAs (circRNAs) noncoding that can be used as diagnostic biomarkers therapeutic targets for human diseases. In this study, we analysed expression hsa_circ_0008925 urinary tubular cells investigated its role fibrosis. Urinary samples were collected from CKD patients with varying degrees...
Background Renal fibrosis is a hallmark of progressive chronic kidney disease (CKD), with emerging evidence linking gut microbiota dysbiosis to progression. Myeloid-derived suppressor cells (MDSCs) have demonstrated renoprotective effects, yet the impact fecal transplantation (FMT) on MDSC-mediated modulation renal remains unclear.
Chronic renal disease (CKD) is a common and irreversible loss of function. Renal fibrosis reflected the degree dysfunction. However, current biomarkers only characterize function instead indicating degree. The potential diagnostic value urinary exosomes derived circRNAs for needs to be further studied.Urine from 3 chronic kidney patients without fibrotic were collected human microarray analysis performed detect expression profile. 110 biopsy-proven CKD 54 healthy controls enrolled urine RNA...
At present, there is no noninvasive biomarker of renal fibrosis. The potential diagnostic value urinary exosome-derived circRNAs from glomerular disease patients for fibrosis still uncertain. Here, we first detected the expression hsa_circ_0008925 in TGF-β1-cultured HK-2 cell-derived exosomes. Secondly, collected urine samples 95 biopsy-proven and 34 healthy controls. was analyzed, correlation with function pathological changes calculated. receiver operating characteristic (ROC) curve...
Macrophages are recognized as vital players in renal fibrosis, with a high degree of heterogeneity and plasticity, the triggering receptor expressed on myeloid cell-2 (TREM-2) is highly macrophages participates progression tissue fibrosis. However, mechanism by which TREM-2 mediates fibrosis still unclear. Our study revealed that exosomes derived from TREM-2-deficient (TREM-2
Objectives The use of combination antiretroviral therapy ( cART ) increases clinical uncertainty about changes in renal function. Specifically, little is known regarding the interaction effects aging, baseline impairment, and stages HIV infection on post‐treatment Methods This analysis included 5533 ‐infected patients 2004–2016. Progression to chronic kidney disease CKD was defined as either two consecutive estimated glomerular filtration rate eGFR measurements < 60 mL/min/1.73 m 2 for ≥...