A5080011846- Autophagy in Disease and Therapy
- Calcium signaling and nucleotide metabolism
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Lysosomal Storage Disorders Research
- Ferroptosis and cancer prognosis
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Renal Diseases and Glomerulopathies
- Pediatric health and respiratory diseases
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic function and diabetes
- Cholesterol and Lipid Metabolism
- Autoimmune and Inflammatory Disorders Research
- Edible Oils Quality and Analysis
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Connective Tissue Growth Factor Research
- Inflammation biomarkers and pathways
- Glutathione Transferases and Polymorphisms
- Reproductive tract infections research
- Epigenetics and DNA Methylation
- RNA regulation and disease
- Natural Compounds in Disease Treatment
Wannan Medical College
1995-2025
Jiangnan University
2023-2025
First Affiliated Hospital of Wannan Medical College
1995-2023
State Key Laboratory of Food Science and Technology
2023
The First People's Hospital of Changde
2008-2021
South China Normal University
2020
Xinxiang Central Hospital
2016
Sarcopenia is a syndrome of age-related loss muscle mass and strength that seriously affects human health, there are currently no effective drugs to treat the disease. Linolenic acid as common n-3 polyunsaturated fatty (n-3 PUFA) known have many beneficial functions. Some studies found PUFA might potential improve sarcopenia. In this study, Caenorhabditis elegans (C. elegans) was used model animal investigate effects linolenic on C. muscles. The results showed 50 μg mL-1 significantly...
Abstract The regulation and homeostasis of autophagy are essential for maintaining organ morphology function. As a lysosomal membrane protein, the effect Sidt2 on kidney structure renal is still unknown. In this study, we found that kidneys −/− mice showed changes in basement thickening, foot process fusion, mitochondrial swelling, suggesting was damaged. Increased urine protein at 24 h indicated function also At same time, absence caused decrease number acidic lysosomes, acid hydrolase...
Chronic renal disease (CKD) is a common and irreversible loss of function. Renal fibrosis reflected the degree dysfunction. However, current biomarkers only characterize function instead indicating degree. The potential diagnostic value urinary exosomes derived circRNAs for needs to be further studied.Urine from 3 chronic kidney patients without fibrotic were collected human microarray analysis performed detect expression profile. 110 biopsy-proven CKD 54 healthy controls enrolled urine RNA...
Primary liver cancer has consistently exhibited a high prevalence and fatality rate, necessitating the investigation of associated diagnostic markers inhibition mechanisms to effectively mitigate its impact. The significance apolipoprotein M (ApoM) in impeding progression neoplastic ailments is progressively gaining recognition. However, comprehensive understanding underlying mechanism advancement remains be elucidated. Recent evidence indicates potential association between ApoM...
Introduction.Chlamydia psittaci is an important cause of community-acquired pneumonia (CAP). The spectrum CAP due to Chlamydia ranges from mild, self-limited acute respiratory failure and the early identification this disease can be challenging. Metagenomic next-generation sequencing (mNGS) bronchoalveolar lavage fluid has potential improve pathogen in severe CAP.Hypothesis/Gap Statement. rapidly identify pathogens CAP. appropriate use antibiotics prognosis caused by psittaci.Aim. aim study...
Disintegrin and metalloproteinase 12 (ADAM12) is thought to trigger the occurrence development of numerous tumours, including colorectal, breast, pancreatic cancers. On basis The Cancer Genome Atlas (TCGA) datasets, in this study, relationship between ADAM12 gene expression hepatocellular carcinoma (HCC), prognostic value relationship, potential mechanisms influencing HCC were evaluated. results showed that was significantly highly expressed liver cancer tissue. high tissue positively...
Polycyclic aromatic hydrocarbons (PAHs) in oil are affected by many factors, including temperature, time, and PAHs precursors. Phenolic compounds, as beneficial endogenous components of oil, often associated with the inhibition PAHs. However, studies have found that presence phenols may lead to increased levels Therefore, this study took Camellia oleifera (C. oleifera) research object, order effect catechin formation under different heating conditions. The results showed PAH4 were generated...
In recent years, abnormal liver lipid metabolism has emerged as one of the important pathogenesis pathways primary cancer. It is highly to identify mechanisms explore potential prevention and treatment targets. Apolipoprotein M specifically expressed in participates metabolism, but evidence that ApoM affects cancer insufficient. The Cancer Genome Atlas (TCGA) database clinical case analysis, well animal level cell analysis suggest expression
At present, there is no noninvasive biomarker of renal fibrosis. The potential diagnostic value urinary exosome-derived circRNAs from glomerular disease patients for fibrosis still uncertain. Here, we first detected the expression hsa_circ_0008925 in TGF-β1-cultured HK-2 cell-derived exosomes. Secondly, collected urine samples 95 biopsy-proven and 34 healthy controls. was analyzed, correlation with function pathological changes calculated. receiver operating characteristic (ROC) curve...
In patients with chronic kidney disease, the abnormal activation of inflammatory pathways is usually an important factor leading to renal fibrosis and further deterioration function. Finding effective intervention targets signaling pathway way treat disease. As a newly discovered lysosomal membrane protein, correlation between SID1 transmembrane family member 2 (Sidt2) has not been reported. The aim this study was investigate effect Sidt2 on inflammation by inhibiting expression gene in...
The objective of this study was to investigate the clinical effects Tripterygium wilfordii on chronic glomerulo nephritis (CGN) and its mechanisms. Eighty-two cases CGN treated in our hospital were randomly divided into observation control groups. group with conventional western medicine, medicine orally-administered T. pills for three courses treatment, each consisting 4 weeks. Changes serum reatinine, blood urea nitrogen, total cholesterol, albumin, 24-h urine protein observed. levels...
Apolipoprotein M (ApoM) is considered a protective factor that inhibits the occurrence and development of liver cancer, but specific underlying mechanisms require further investigation. Previous studies have demonstrated ApoM gene knockout promotes expression transcription sterol regulatory element-binding protein 1 (SREBP1; also known as SREBF1) in livers mice. SREBF1 closely associated with factors involved fatty acid synthesis has role promotion tumor progression. The present study...
Margarine is a typical water-in-oil (W/O) emulsion fat product. Due to the presence of water-oil interface, oil oxidation in system interface reaction, which much faster than that bulk and shows different mechanisms. The analysis Rancimat electron spin resonance indicated α-tocopherol EGCG show synergistic antioxidant effects margarine. After 20 days accelerated storage, effect compound (50 mg/kg + 350 EGCG) on margarine was significantly higher single EGCG. Based results antioxidants...
Abstract The role of Sidt2 in the process glucose and lipid metabolism has been recently reported. However, whether is involved metabolic regulation skeletal muscle remains unknown. In this study, for first time, using muscle‐selective knockout mice, we found that was vital quality control mitochondria mouse muscle. These mice showed significantly reduced tolerance structurally abnormal mitochondria. Deletion gene resulted decreased expression mitochondrial fusion protein 2 (Mfn2)...
Diabetic nephropathy (DN) is one of the most lethal complications diabetes mellitus with chronic inflammation. We have examined role inflammatory chemokine CCL24 in DN. observed that serum levels were significantly elevated patients Not only that, expression was increased kidneys DN mice. The kidney mice showed renal fibrosis and characterized an vitro podocyte cell model high glucose. Western blot analysis under high-glucose conditions. Stimulation glucose (35 mmol/L) resulted increase...
To explore the regulatory mechanism of human hepatocyte apoptosis induced by lysosomal membrane protein Sidt2 knockout.The knockout (Sidt2-/-) cell model was constructed in HL7702 cells using Crispr-Cas9 technology.The levels and key autophagy proteins LC3-II/I P62 were detected Western blotting, formation autophagosomes observed with MDC staining.EdU incorporation assay flow cytometry performed to observe effect on proliferation apoptosis.The chloroquine at saturating concentration...
Preeclampsia (PE) is a complex pregnancy-related disease that endangers the safety of maternal and fetal. The purpose this study to reveal pathogenesis preeclampsia discover new predictors from perspective peptidomics. umbilical cord blood PE control group was analyzed by A peptide named Regulation Proliferation Process in (ROPPIP) screened out explore its role proliferation, migration apoptosis trophoblast cells preeclampsia.We compared patients with normal pregnant women using liquid...
In order to promote high-quality online teaching and learning of Chinese colleges universities during the COVID-19 pandemic. This study conducted an questionnaire survey on college students in different China, analyzed data collected from 155 valid questionnaires gain in-depth understanding status specific needs epidemic. According results, model epidemic was constructed based mixed theory generative theory, for proposed upgrade quality implementation strategies.