A5100320901- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Digestive system and related health
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cellular transport and secretion
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- Helicobacter pylori-related gastroenterology studies
- Proteoglycans and glycosaminoglycans research
- Thermal Expansion and Ionic Conductivity
- Neuroscience and Neuropharmacology Research
- Colorectal and Anal Carcinomas
- Force Microscopy Techniques and Applications
- RNA Research and Splicing
- Herpesvirus Infections and Treatments
- Genetic factors in colorectal cancer
- Fibroblast Growth Factor Research
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Colorectal Cancer Surgical Treatments
Beijing Tongren Hospital
2021-2024
Capital Medical University
2021-2024
Cornell University
2021-2024
Weill Cornell Medicine
2021-2024
Guizhou University
2024
Rutgers, The State University of New Jersey
2012-2023
Shanghai Tenth People's Hospital
2014-2022
University of Science and Technology of China
2022
Tongji University
2014-2022
Zhongnan Hospital of Wuhan University
2022
Abstract O-GlcNAcylation has been implicated in the tumorigenesis of various tissue origins, but its function liver is not clear. Here, we demonstrate that can enhance expression, stability and Yes-associated protein (YAP), downstream transcriptional regulator Hippo pathway a potent oncogenic factor cancer. induces transformative phenotypes cancer cells YAP-dependent manner. An O-GlcNAc site YAP was identified at Thr241, mutating this decreased O-GlcNAcylation, stability, pro-tumorigenic...
Hooking into antigen transfer Segmented filamentous bacteria (SFB) are anaerobic, spore-forming, clostridia-like organisms that important immune modulators in the mammalian gut. For some reason, SFB do not provoke inflammatory responses. Ladinsky et al. probed mechanistic basis of this soothing effect mice. attach tightly to intestinal epithelial cells via a hook-like structure. Bacterial material is extruded from hook and enters host cell by endocytosis. An protein called P3340 shuttled...
Amyloid diseases encompass >20 medical disorders that include amyloid protein A (AA) amyloidosis, Alzheimer's disease, and type 2 diabetes. common feature of these conditions is the selective organ deposition disease-specific fibrillar proteins, along with sulfated glycosaminoglycan, heparan sulfate. We have generated transgenic mice overexpress human heparanase tested their susceptibility to induction. Drastic shortening sulfate chains was observed in heparanase-overproducing organs,...
Alzheimer's disease (AD) is attributable to synapse dysfunction and loss, but the nature progression of presynaptic structural functional changes in AD are essentially unknown. We expressed wild-type or arctic form β amyloid 1-42 (Aβ) a small group neurons adult fly performed extensive time course analysis function structure both axon terminals at identified single-neuron level. Aβ accumulated intracellularly induced range age-dependent changes, including depletion mitochondria, slowdown...
Abstract Although Yes-associated protein (YAP) is very important to liver cancer, its nuclear localisation prevents consideration as a promising therapeutic target and diagnostic biomarker. Recently, we reported that the protumourigenic roles of YAP in cancer are indispensable for transcription factor CP2 (TFCP2) Hippo-independent manner; however, proteins act upstream simultaneously control TFCP2 remain unclear. The aim this study was uncover such evaluate whether they potential...
Mutations in the APC or β-catenin genes are well-established initiators of colorectal cancer, yet modifiers that facilitate survival and progression nascent tumor cells not well defined. Using genetic pharmacologic approaches mouse cancer human xenograft models, we show incipient intestinal activate CDC42, an APC-interacting small GTPase, as a crucial step malignant progression. In mouse, Cdc42 ablation attenuated tumorigenicity mutant carrying single mutations. Similarly, with relatively...
Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function poorly understood. Here, we show that TFCP2 required for and malignancy. Mechanistically, stimulated via a WW-PSY interaction. also stability inhibiting βTrCP. Notably, genomic co-occupancy of revealed. acts as co-factor stimulates facilitating binding motif (YBF)-containing factors. Interestingly, YAP-TEAD interaction TEAD target gene expression. Finally,...
Abstract Epstein-Barr virus (EBV) is associated with a range of epithelial and B cell malignancies as well autoimmune disorders, for which there are still no specific treatments or effective vaccines. Here, we isolate EBV gH/gL-specific antibodies from an EBV-infected individual. One antibody, 1D8, efficiently neutralizes infection two major target types, cells cells. In humanized mice, 1D8 provides protection against high-dose challenge by substantially reducing viral loads tumor burden....
MO3 (M = Mo, W) or VI-VI binary compounds are important semiconducting oxides that show great promise for a variety of applications. In an effort to tune and enhance their properties in systematic manner we have applied designing strategy deliberately introduce organic linker molecules these perovskite-like crystal lattices. This approach has led wealth new hybrid structures built on one-dimensional (1D) two-dimensional (2D) modules. The semiconductors exhibit number greatly improved...
Fatty acid synthase (FASN) is upregulated in breast cancer and correlates with poor prognosis. FASN contributes to mammary oncogenesis serves as a bona fide target therapies. MicroRNAs inhibit gene expression through blocking mRNA translation or promoting degradation by targeting their 3'-UTRs. We identified four microRNAs two microRNA clusters miR-15a-16-1 miR-497-195 that share common seed sequence the 3'-UTR of mRNA. In reporter assays, both these inhibited construct containing 3'-UTR....
Ginsenoside-Rb1 (Rb1), a major active component of ginseng, has many benefits for cardiovascular disease and diabetes mellitus (DM), but the effect mechanism on diabetic cardiomyopathy are not clear. In present study, we found that Rb1-feeding significantly improved cardiac dysfunction abnormal cardiomyocytes calcium signaling caused by diabetes. This was because Rb1 reduced Ca2+ leakage overactivated ryanodine receptor 2 (RyR2) increased uptake sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA...
Abstract Globally, hepatocellular carcinoma (HCC) is one of the most lethal malignant tumors. Studies have shown that alterations in tumor immune microenvironment (TIME) play a significant role pathogenesis and progression HCC, notably, lipid metabolism has been to regulate TIME. Therefore, predicting prognosis efficacy immunotherapy patients with metabolism-related prognostic factors are highly relevant. mRNA expression data HCC were obtained from Cancer Genome Atlas (TCGA), International...
Abstract The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their poor response to current targeted therapy, difficult preneoplastic detection, challenging endoscopic resection make identification of requirements a priority. Here, we demonstrate that phosphorylation SCAP by atypical PKC (aPKC), PKCλ/ι promotes its...
// Hao Cui 1,* , Ying-xia Tan 1,2,* Cecilia Österholm 3,4 Xiao Zhang 5 Ulf Hedin 3 Israel Vlodavsky 6 and Jin-Ping Li 1 Department of Medical Biochemistry Microbiology, SciLifeLab Uppsala, The Biomedical Center, University Husargatan, Sweden 2 Tissue Engineering, Beijing Institute Transfusion Medicine, Beijing, China Molecular Medicine Surgery, Karolinska Institutet, Stockholm, 4 Cell Therapy Institute, Nova Southeastern University, Fort Lauderdale, FL, USA Neuroscience Pharmacology, Cancer...
Abstract The effects of polarized membrane trafficking in mature epithelial tissue on cell growth and cancer progression have not been fully explored vivo. A majority colorectal cancers reduced mislocalized Rab11, a small GTPase dedicated to recycling endosomes. Patients with low Rab11 protein expression poor survival rates. Using genetic models across species, we show that intact endosome function restrains aberrant elicited by APC or RAS mutations. Loss led dysplasia early animal...
Abstract Background Ovarian cancer is the most lethal gynecologic cancer. Chemoresistance, especially platinum-resistance, closely related to metastasis of ovarian cancer, however, molecular basis by which links chemoresistance and remains vague. Disordered arachidonic acid (AA) metabolism has been shown play an important role in advanced This study aimed explore underlying mechanism involving eicosanoid that controlling Methods Cisplatin (DDP)-resistant SKOV3 (SKOV3-R) cells were constantly...
Abstract Leukemia inhibitory factor (LIF) is a cytokine essential for maintaining pluripotency of mouse embryonic stem cells. However, its role in adult intestinal cells (ISCs) unclear. The epithelium has high self-renewal rate driven by ISCs crypts. Here, we find that LIF present the ISC niche crypts and critical function epithelial homeostasis regeneration. Mechanistically, maintains β-catenin activity through AKT/GSK3β signaling to regulate functions. deficiency mice impairs renewal under...