A5053162695- Gut microbiota and health
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Neonatal Respiratory Health Research
- HIV/AIDS Research and Interventions
- Influenza Virus Research Studies
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
- Clostridium difficile and Clostridium perfringens research
- Immunotherapy and Immune Responses
- HIV-related health complications and treatments
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Regulation of Appetite and Obesity
- Digestive system and related health
- Tryptophan and brain disorders
- Eosinophilic Esophagitis
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Macrophage Migration Inhibitory Factor
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
Weizmann Institute of Science
2017-2024
ETH Zurich
2014-2021
Alveolar macrophages (AM) are critical for defense against bacterial and fungal infections. However, a definitive role of AM in viral infections remains unclear. We here report that play key survival to influenza vaccinia virus infection by maintaining lung function thereby protecting from asphyxiation. Absence GM-CSF-deficient (Csf2−/−) mice or selective depletion wild-type resulted impaired gas exchange fatal hypoxia associated with severe morbidity infection, while clearance was affected...
During cell entry, capsids of incoming influenza A viruses (IAVs) must be uncoated before viral ribonucleoproteins (vRNPs) can enter the nucleus for replication. After hemagglutinin-mediated membrane fusion in late endocytic vacuoles, vRNPs and matrix proteins dissociate from each other disperse within cytosol. Here, we found that capsid disassembly, IAV takes advantage host cell's aggresome formation disassembly machinery. The mimicked misfolded protein aggregates by carrying unanchored...
Type-2 immune responses are well-established drivers of chronic inflammatory diseases, such as asthma, and represent a large burden on public health systems. The transcription factor PPARγ is known to promote M2-macrophage alveolar macrophage development. Here, we report that plays key role in both T cells dendritic (DCs) for development type-2 responses. It predominantly expressed mouse Th2 vitro vivo well human from allergic patients. Using conditional knockouts, show signaling cells,...
People with diabetes feature a life-risking susceptibility to respiratory viral infection, including influenza and SARS-CoV-2 (ref.
Steroid-resistant asthma is often characterized by high levels of neutrophils and mixed TH2/TH17 immune profiles. Indeed, are key drivers chronic lung inflammation in multiple respiratory diseases. Their numbers correlate strongly with disease severity, their presence associated exacerbation inflammation.What factors drive development neutrophil-mediated remains largely unknown, we sought to study the role GM-CSF as a potential regulator asthma.Different experimental animal models were used...
Abstract PI3Ks have been identified as key signaling proteins involved in many basic biologic processes health and disease. Transgenic animals essential tools to study the underlying molecular mechanisms this context therefore, widely used elucidate role of these factors different settings. More specifically, PI3Kγ, a subunit highly expressed hematopoietic system, has implicated play an important inflammatory diseases well cancer. Here, we report identification multiple, additional,...
Phosphoinositide-3-kinases have been shown to be involved in influenza virus pathogenesis. They are targeted directly by proteins and essential for efficient viral replication infected lung epithelial cells. However, date the role of PI3K signaling infection vivo has not thoroughly addressed. Here we show that one subunits, p110γ, is fact critically required mediating host's antiviral response. PI3Kγ deficient animals exhibit a delayed clearance increased morbidity during respiratory with...