A5100718251- Ferroptosis and cancer prognosis
- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Renal Diseases and Glomerulopathies
- Gout, Hyperuricemia, Uric Acid
- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
- Acute Kidney Injury Research
- Enzyme Production and Characterization
- Mast cells and histamine
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- RNA regulation and disease
- Renin-Angiotensin System Studies
- Diabetes and associated disorders
- Dietary Effects on Health
- Retinal and Optic Conditions
- Plant pathogens and resistance mechanisms
- Erythropoietin and Anemia Treatment
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Bamboo properties and applications
- Genetics, Bioinformatics, and Biomedical Research
Shanxi University
2025
Shaanxi University of Chinese Medicine
2025
Ministry of Agriculture and Rural Affairs
2024
Nanjing Agricultural University
2024
First Affiliated Hospital of Wannan Medical College
2008-2022
Wannan Medical College
2008-2022
Northwest A&F University
2021
Shanghai First People's Hospital
2020
Huazhong University of Science and Technology
2019
Tongji Hospital
2019
CpG island methylator phenotype (CIMP), a common biological phenomenon characterized by subset of concurrently methylated genes, can have an influence on the progression multiple cancers. However, potential mechanism CIMP in hepatocarcinogenesis and its clinical relevance remains only partially understood.We used methylation array from cancer genome atlas (TCGA) to stratify HCC patients into different subtypes, evaluated their correlation with characteristics. In addition, mutation, CNV,...
Metastasis is the major cause of prostate cancer deaths and there a need for clinically relevant in vivo models allowing elucidation molecular cellular mechanisms underlying metastatic behavior. Here we describe development new model system cancer. Pieces tissue from patient were grafted testosterone-supplemented male NOD-SCID mice at subrenal capsule graft site permitting high tumor take rates. After five serial transplantations, tissues into mouse prostates. Resulting tumors suspected...
Abstract Carcinoma of the prostate is most common cancer in men. Treatment aggressive involves a regiment radical prostectomy, radiation therapy, chemotherapy and hormonal therapy. Despite significant improvements last decade, treatment remains unsatisfactory, because fraction cancers develop resistance to multiple treatments become incurable. This prompts an urgent need investigate molecular mechanisms underlying evolution therapy-induced either form castration-resistant (CRPC) or...
To evaluate the association between serum uric acid (SUA) levels with CKD in elderly health checkup population and explore gender difference.A total of 4242 subjects were included cross-sectional study. All participated annual June 2016 2017. Chronic kidney disease (CKD) was defined by estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2. We examined SUA CKD. Multivariate binary logistic regression analysis used to estimate odds ratios (ORs) 95% confidence intervals (95%CIs)...
Abstract Background Elevated serum uric acid (SUA) has been associated with vascular cognitive impairment (CI) in the elderly. However, its relationship function elderly patients receiving maintenance hemodialysis (MHD) not yet elucidated. Objective The is prevalent MHD patients. Various insults may contribute to MHD. aim of this study was investigate between SUA and CI Methods A total 180 subjects from two hospitals were enrolled our study. Cognitive domains evaluated by MMSE at beginning...
Acute kidney injury (AKI) is a devastating condition with high morbidity and mortality rates. The pathological features of AKI are tubular injury, infiltration inflammatory cells, impaired vascular integrity. Pyruvate kinase the final rate-limiting enzyme in glycolysis pathway. We previously showed that pyruvate M2 (PKM2) plays an important role regulating glycolytic reprogramming fibroblasts renal interstitial fibrosis. present study aimed to determine PKM2 fibroblast activation during...
At present, there is no noninvasive biomarker of renal fibrosis. The potential diagnostic value urinary exosome-derived circRNAs from glomerular disease patients for fibrosis still uncertain. Here, we first detected the expression hsa_circ_0008925 in TGF-β1-cultured HK-2 cell-derived exosomes. Secondly, collected urine samples 95 biopsy-proven and 34 healthy controls. was analyzed, correlation with function pathological changes calculated. receiver operating characteristic (ROC) curve...
Renal fibrosis is a common outcome of all pathological types chronic kidney disease (CKD). However, the noninvasive detection renal remains challenge. We collected urine samples from 154 biopsy-proven IgA nephropathy (IgAN) patients and 61 healthy controls. The expression mTOR was measured correlation with function parameter indicators. receiver operating characteristic (ROC) curve for diagnosis IgAN calculated. urinary mammalian target rapamycin (mTOR) decreased in patients. correlated...
Abstract Background Amyloid-β (Aβ), a component of age-related macular degeneration (AMD) hallmark drusen, induces retinal pigment epithelium (RPE) cell and promotes the progress AMD. Evidence shows that epigenetics mechanism is involved in regulation In this study, we aimed to investigate roles N6-methyladenosine (m6A) its demethylase fat mass obesity-associated gene (FTO) Aβ-mediated degeneration. Methods The molecular characteristics morphology FTO were examined by quantitative Real-Time...
Abstract Advances in the development of novel nanocarriers and their applications area drug delivery have inspired created new opportunities for anticancer formulation development. About 10 nanomedicines various dosage forms liposomes polymeric micelles been approved since 1995, with albumin-bound paclitaxel (Abraxane) being a milestone treatment variety aggressive cancers. These outperform low molecular weight chemotherapeutic agents by favorable pharmacokinetics tissue distribution,...