A5101856926- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Genetic Mapping and Diversity in Plants and Animals
- Phytochemicals and Antioxidant Activities
- Animal Virus Infections Studies
- Cholesterol and Lipid Metabolism
- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Genetics and Plant Breeding
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Wheat and Barley Genetics and Pathology
- melanin and skin pigmentation
- Plant tissue culture and regeneration
- Genomics and Phylogenetic Studies
- Advances in Cucurbitaceae Research
- Genetics, Aging, and Longevity in Model Organisms
- Chromosomal and Genetic Variations
- Biochemical Analysis and Sensing Techniques
- Plant Genetic and Mutation Studies
- Mechanisms of cancer metastasis
- Machine Learning in Bioinformatics
- Diet, Metabolism, and Disease
Jiangnan University
2021-2025
Tianjin Agricultural University
2020-2024
Jiangxi Normal University
2024
Huazhong Agricultural University
2017-2023
China Agricultural University
2011-2023
Sun Yat-sen University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Ministry of Agriculture and Rural Affairs
2022
Henan Agricultural University
2020-2021
Henan University
2020-2021
ABSTRACT Aims Circular RNA forkhead box O3 (circFOXO3) is crucial in regulating inflammation lung and heart injuries. However, its role periodontitis remains unclear. We sought to elucidate the effects of circFOXO3 on progression related molecular mechanisms. Methods Reverse‐transcription quantitative polymerase chain reaction fluorescence situ hybridization were used quantify localize expression. The mechanism by which promotes was investigated using epithelial cells, human gingival...
A loop‐mediated isothermal amplification (LAMP) assay for detection of Meloidogyne enterolobii (Me‐LAMP) was developed based on the sequences 5S ribosomal DNA (5S rDNA) and intergenic spacer 2 (IGS2) segment. The LAMP achieved at 65°C conditions within 1–1·5 h. Its amplicons were confirmed using gel electrophoresis, Sac I enzyme analysis, lateral flow dipstick (LFD) assay, visual inspection through SYBR Green calcein staining. results demonstrated that Me‐LAMP able to specifically detect M....
Long noncoding RNAs (lncRNAs) play important roles in the spatial and temporal regulation of muscle development regeneration. Nevertheless, determination their biological functions mechanisms underlying regeneration remains challenging. Here, we identified a lncRNA named lncMREF (lncRNA enhancement factor) as conserved positive regulator among mice, pigs humans. Functional studies demonstrated that lncMREF, which is mainly expressed differentiated satellite cells, promotes myogenic...
The dynamics of gene expression in crop grains has typically been investigated at the transcriptional level. However, this approach neglects translational regulation, a widespread mechanism that rapidly modulates to increase plasticity organisms. Here, we performed ribosome profiling and polysome obtain comprehensive translatome data set developing bread wheat (Triticum aestivum) grains. We further genome-wide during grain development, revealing translation many functional genes is modulated...
Sarcopenia is a syndrome of age-related loss muscle mass and strength that seriously affects human health, there are currently no effective drugs to treat the disease. Linolenic acid as common n-3 polyunsaturated fatty (n-3 PUFA) known have many beneficial functions. Some studies found PUFA might potential improve sarcopenia. In this study, Caenorhabditis elegans (C. elegans) was used model animal investigate effects linolenic on C. muscles. The results showed 50 μg mL-1 significantly...
Infectious bronchitis virus (IBV), an ongoing emergence enveloped with a single-stranded positive-sense RNA genome, belongs to the Gammacoronavirus genus in Coronaviridae family. IBV-associated tracheitis, nephritis, salpingitis, proventriculitis and egg drop have caused devastating economic losses poultry industry worldwide. Since end of 2018, remarkably increasing number commercial broilers layers, vaccinated or not, were infected IBV China. Here, we described two IB outbreaks severe...
Astroviruses are a non-enveloped virus with large host range breadth. AstV-associated gastroenteritis in human and animal, nephritis chicken, gout gosling hepatitis duckling pose great threats to public health poultry industry. Since early 2020, continuous emergence of fatal goose astrovirus (GAstV) infections characterized by articular visceral was reported China. Here, we described two outbreaks emerging disease different farms central Two virulent GAstV strains, designated as...
Abstract Myogenesis, the process of skeletal muscle formation, is a highly coordinated multistep biological process. Accumulating evidence suggests that long non‐coding RNAs (lncRNAs) are emerging as gatekeeper in myogenesis. Up to now, most studies on development‐related lncRNAs mainly focussed humans and mice. In this study, novel expressed lncRNA, named lnc23, localized nucleus, was found differentially different stages embryonic development myogenic differentiation. The knockdown...
Intracellular gene transfers (IGTs) between the nucleus and organelles, including plastids mitochondria, constantly reshape nuclear genome during evolution. Despite substantial contribution of IGTs to variation, dynamic trajectories at pangenomic level remain elusive. Here, we developed an approach, IGTminer, that maps evolutionary using collinearity reannotation across multiple assemblies. We applied IGTminer create a organellar (NOG) map 67 genomes covering 15 Poaceae species, important...
species have a long history of use in traditional medicine Asian and European countries been considered to possess resistance the challenges presented by extreme altitudes. However, influence different
Myogenic differentiation factor (MyoD) is a master transcription in muscle development and differentiation. Although several long non-coding RNAs (lncRNAs) linked to MyoD have been found influence development, the functions of many lncRNAs not explored. Here we utilized lncRNA mRNA microarray analysis identify potential regulated by cells. A total 997 differentially expressed (335 up-regulated 662 down-regulated) 1,817 mRNAs (148 1,669 were identified after knockdown C2C12 Functional...
// Mingfei Zhu 1, * , Rong Zheng Yiwen Guo 1 Yunxia Zhang 3 and Bo Zuo 2 Key Laboratory of Swine Genetics Breeding Ministry Agriculture & Animal Genetics, Reproduction Education, College Science Technology, Huazhong Agricultural University, Wuhan 430070, P.R. China The Cooperative Innovation Center for Sustainable Pig Production, Life Agronomy, Zhoukou Normal 466000, These authors have contributed equally to this work Correspondence to: Zuo, email: zuobo@mail.hzau.edu.cn Keywords:...
Myostatin (MSTN) is an important negative regulator of muscle growth and development. In this study, we performed comparatively the proteomics analyses gluteus tissues from MSTN +/− Mongolian cattle (MG.MSTN ) wild type (MG.WT) using a shotgun-based tandem mass tag (TMT) 6-plex labeling method to investigate regulation mechanism on development bovine skeletal muscle. A total 1,950 proteins were identified in MG.MSTN MG.WT. Compared with MG.WT cattle, 320 differentially expressed including...
Myoblast differentiation is essential for the formation of skeletal muscle myofibers. Profilin1 (Pfn1) has been identified as an actin-associated protein, and shown to be critically important cellular function. Our previous study found that PFN1 may inhibit bovine satellite cells, but underlying mechanism not known. Here, we confirmed negatively regulated myogenic cells. Immunoprecipitation assay combined with mass spectrometry showed Cdc42 was a binding protein PFN1. could activated by like...