A5102735117- Genetics and Plant Breeding
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Platelet Disorders and Treatments
- Wheat and Barley Genetics and Pathology
- Blood groups and transfusion
- Glioma Diagnosis and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Skin and Cellular Biology Research
- Cervical and Thoracic Myelopathy
- Light effects on plants
- Histone Deacetylase Inhibitors Research
- VLSI and Analog Circuit Testing
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced biosensing and bioanalysis techniques
- Protein Degradation and Inhibitors
- Higher Education and Teaching Methods
- Genetic and rare skin diseases.
- Nitrogen and Sulfur Effects on Brassica
- Plant nutrient uptake and metabolism
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Plant Gene Expression Analysis
- melanin and skin pigmentation
- Blood transfusion and management
China Agricultural University
2020-2024
Shanghai University of Traditional Chinese Medicine
2018-2024
XinHua Hospital
2016-2024
Luoyang Institute of Science and Technology
2010-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2021-2024
Jiujiang University
2012-2022
Fujian University of Traditional Chinese Medicine
2022
Hainan University
2022
Yueyang Hospital
2018-2021
Yinchuan First People's Hospital
2021
Platinum(IV) prodrug diaminedichlorodihydroxyplatinum (ACHP) conjugated with a histone deacetylase (HDAC) inhibitor valproic acid (VA), VAAP, exhibited strong synergistic cytotoxicity, about 50–100 times more cytotoxic than ACHP or its simple mixture VA, against various human carcinoma cell lines. VAAP could be quickly absorbed in the membrane and diffused into cytosol. loaded polyethylene glycol–polycaprolactone micelles (PEG-PCL) was taken up via endocytosis. The cytosolic intracellular...
Most human cancers develop from stem and progenitor cell populations through the sequential accumulation of various genetic epigenetic alterations. Cancer cells have been identified medulloblastoma (MB), but a comprehensive understanding MB stemness, including interactions between tumor immune microenvironment is lacking. Here, we employed trained stemness index model based on an existent one-class logistic regression (OCLR) machine-learning method to score samples; then obtained two...
<h3>Background</h3> In light of recent reports diminished platelet serotonin concentration and increased plasma levels in patients with Alzheimer disease (AD), we hypothesized that a state heightened activation might be present AD. <h3>Objective</h3> To compare baseline unstimulated platelets AD control subjects. <h3>Patients Methods</h3> Flow cytometry was used to measure 91 probable 40 age-matched Groups were compared for percentage circulating aggregates, expression CD62p, formation...
Members of plant WRKY gene family are ancient transcription factors that function in growth and development respond to biotic abiotic stresses. In our present study, we have investigated genes Brachypodium distachyon, a new model Poaceae. We identified total 86 from B. distachyon explored their chromosomal distribution evolution, domain alignment, promoter cis-elements, expression profiles. Combining the analysis phylogenetic tree BdWRKY result profiling, results showed most clustered pairs...
Significance Plant seedlings encounter increasing levels of UV-B irradiation during their emergence from soil as they undergo a light-induced developmental process termed photomorphogenesis. However, less is known about the molecular mechanisms underlying plant responses to this invisible part light spectrum. Here, we reveal that signal interpreted coordinately by two sets E3 ligases and transcription factor in Arabidopsis . The UV-B–inducible CUL4-DDB1–RUP1/RUP2 complex targets master HY5...
In plants, the HAK (high-affinity K⁺)/KUP (K⁺ uptake)/KT transporter) family represents a large group of potassium transporters that play important roles in plant growth and environmental adaptation. Although HAK/KUP/KT genes have been extensively investigated many species, they remain uncharacterized wheat, especially those involved response to stresses. this study, 56 wheat (hereafter called TaHAKs) were identified by genome-wide search using recently released genomic data. Phylogenetic...
The dynamics of gene expression in crop grains has typically been investigated at the transcriptional level. However, this approach neglects translational regulation, a widespread mechanism that rapidly modulates to increase plasticity organisms. Here, we performed ribosome profiling and polysome obtain comprehensive translatome data set developing bread wheat (Triticum aestivum) grains. We further genome-wide during grain development, revealing translation many functional genes is modulated...
Programmed cell death 1 ligand (PD-L1) is a of programmed (PD-1) that functions as an immune checkpoint by down-regulating responses. To determine whether PD-L1 therapy target in vitiligo treatment, Pmel-1 mice were treated with fusion protein. Treatment this protein significantly reversed/suppressed depigmentation development adult mice. Mechanistically, enrichment regulatory T cells (Treg) the skin was detected after treatment Furthermore, Tregs abundance also increased both spleen and...
The IL-6/STAT3 signaling pathway is required for the development of psoriatic lesions, and tripartite motif-containing 27 (TRIM27) a protein inhibitor activated STAT3 (PIAS3)-interacting that could modulate IL-6-induced activation. However, whether TRIM27 associated with in psoriasis remains enigmatic. expression gene set enrichment analysis patients were determined using bioinformatics. Human keratinocyte HaCaT cells treated recombinant IL-6 (rh-IL-6) transduced lentivirus silencing and/or...
Aim: To prepare RGD-modified long circulating liposome (LCL) loading matrine (RGD-M-LCL) to improve the tumor-targeting and efficacy of matrine.Methods: LCL which was prepared with HSPC, cholesterol, DSPE-PEG2000 DSPE-PEG-MAL modified an RGD motif confirmed by high performance liquid chromatography (HPLC).The encapsulation efficiency RGD-M-LCL also detected HPLC.MTT assay used examine effects on proliferation Bcap-37, HT-29 A375 cells.The percentage apoptotic cells morphological changes in...
Glioblastoma (GBM) is the most common and malignant primary brain cancer in adults. Despite multimodality treatment, prognosis still poor. Therefore, further work urgently required to discover novel therapeutic strategies for GBM treatment. The synergistic effects of cotreatment with histone deacetylase (HDAC) inhibitor panobinostat bromodomain JQ1 or OTX015 were validated using cell viability assays lines. Furthermore, inhibitory mechanisms investigated via an EdU proliferation assay,...
The electrochemical aptasensor for AFB1 detection based on HCR.
The present paper describes a flow cytometric method for assay of platelet aggregates (PAg) in blood. This combines and simplifies previously reported techniques, simultaneously enumerating PAg formed upon activation, their expression activation marker CD62P (P-selectin), content bound leukocytes (LPAg). sensitivity this to low levels agonists (ADP, collagen) is compared conventional aggregometry some features platelet-leukocyte interaction are explored. results were: (1) ADP or collagen...
Amides with β-carboxylic acid groups are stable and negatively charged at physiological pH, but hydrolyze back to the corresponding amines anhydrides once in an acidic environment. We thereby developed charge-reversal nanocarriers for drug delivery. In these systems, served only as amidize cationic polymers had no therapeutic use after being cleaved from carrier cells. Herein, we utilized characteristic anhydride structure of norcantharidin (NCTD) pH-dependent hydrolysis its amides novel...
Glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite multiple treatment strategies, prognosis still poor. This study aimed to evaluate efficacy of combination GBM with histone deacetylase (HDAC) inhibitor panobinostat and dual phosphoinositide 3-kinase (PI3K) mammalian target rapamycin (mTOR) BEZ235. cells were exposed BEZ235 alone or combination, after which cell viability, proliferation apoptosis detected. Furthermore, inhibitory mechanisms investigated...
Abstract Variants in the melanocortin-1 receptor ( MC1R ) gene, encoding a trimeric G-protein-coupled and activated by α-melanocyte-stimulating hormone (α-MSH), are frequently associated with red or blonde hair, fair skin, freckling, skin sensitivity to ultraviolet (UV) light. Several hair color variants of also increased melanoma risk. affect risk independent phenotype. Here, we demonstrated that is critical factor chromosome stability centromere integrity melanocytes. α-MSH/MC1R...