A5077919782- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Wheat and Barley Genetics and Pathology
- Plant Molecular Biology Research
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Marine and coastal ecosystems
- Chromosomal and Genetic Variations
- Plant Stress Responses and Tolerance
- T-cell and B-cell Immunology
- Heat shock proteins research
- RNA and protein synthesis mechanisms
- Wind Turbine Control Systems
- Real-time simulation and control systems
- Immune Response and Inflammation
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Genetic Mapping and Diversity in Plants and Animals
- Immune Cell Function and Interaction
- Marine Biology and Ecology Research
- Plant Disease Resistance and Genetics
Thomas Jefferson University
2021-2025
Henan Agricultural University
2024
South China Sea Institute Of Oceanology
2020-2024
Institute of Oceanology
2020-2024
Chinese Academy of Sciences
2016-2024
China Agricultural University
2019-2024
Army Medical University
2024
Southwest Hospital
2024
Center for Excellence in Molecular Cell Science
2017-2024
Northwest Institute of Eco-Environment and Resources
2022-2023
Significance Tumor suppressor genes (TSGs) play important roles in lung cancer initiation, progression, and even metastasis. Here, we take advantage of the clustered regularly interspaced short palindromic repeats/Cas9-mediated screening vivo technique to identify multiple tumor contributing malignant progression. Using genetically engineered mouse models, further confirm tumor-suppressive role epigenetic regulator UTX provide therapeutic implications for UTX-deficient tumors. Thus, our work...
Heat stress greatly threatens crop production. Plants have evolved multiple adaptive mechanisms, including alternative splicing, that allow them to withstand this stress. However, how splicing contributes heat responses in wheat (Triticum aestivum) is unclear. We reveal the shock transcription factor gene TaHSFA6e alternatively spliced response generates two major functional transcripts: TaHSFA6e-II and TaHSFA6e-III. TaHSFA6e-III enhances transcriptional activity of three downstream protein...
Human lung adenosquamous cell carcinoma (LUAS), containing both adenomatous and squamous pathologies, harbors strong plasticity is significantly associated with poor prognosis. We established an up-to-date comprehensive genomic transcriptomic landscape of LUAS in 109 Chinese specimens demonstrated development via adeno-to-squamous transdifferentiation. Unsupervised clustering dynamic network biomarker analysis identified inflammatory subtype as the critical transition stage during...
The mRNA-LNP vaccine has received much attention during the COVID-19 pandemic since it served as basis of most widely used SARS-CoV-2 vaccines in Western countries. Based on early clinical trial data, these were deemed safe and effective for all demographics. However, latest data raise serious concerns about safety effectiveness vaccines. Here, we review some efficacy identified to date. We also discuss potential mechanism observed adverse events related use whether they can be mitigated by...
Abstract Heat stress threatens global wheat ( Triticum aestivum ) production, causing dramatic yield losses worldwide. Identifying heat tolerance genes and comprehending molecular mechanisms are essential. Here, we identify a gene, TaSG-D1 E286K , in Indian dwarf sphaerococcum ), which encodes an STKc_GSK3 kinase. improves compared to by enhancing phosphorylation stability of downstream target TaPIF4 under condition. Additionally, reveal evolutionary footprints during selective breeding...
Metastasis is the dominant cause of patient death in small-cell lung cancer (SCLC), and a better understanding molecular mechanisms underlying SCLC metastasis may potentially improve clinical treatment. Through genome-scale screening for key regulators mouse Rb1-/- Trp53-/- using pooled CRISPR/Cas9 library, we identified Cullin5 (CUL5) suppressor cytokine signaling 3 (SOCS3), two components Cullin-RING E3 ubiquitin ligase complex, as top candidates. Mechanistically, deficiency CUL5 or SOCS3...
Heat stress is a major limiting factor for global wheat production and causes dramatic yield loss worldwide. The TaMBF1c gene upregulated in response to heat wheat. Understanding the molecular mechanisms associated with responses will pave way improve thermotolerance. Through CRISPR/Cas9-based editing, polysome profiling coupled RNA-sequencing analysis, protein-protein interactions, we show that conferred via regulating specific translation results showed evolutionarily conserved diploid,...
Abstract Background The massive structural variations and frequent introgression highly contribute to the genetic diversity of wheat, while huge complex genome polyploid wheat hinders efficient genotyping abundant varieties towards accurate identification, management, exploitation germplasm resources. Results We develop a novel workflow that identifies 1240 high-quality large copy number variation blocks (CNVb) in at pan-genome level, demonstrating CNVb can serve as an ideal DNA...
Alternative splicing (AS) occurs extensively in eukaryotes as an important mechanism for regulating transcriptome complexity and proteome diversity, but variation the AS landscape response to domestication polyploidization crops is unclear. Hexaploid wheat (AABBDD, Triticum aestivum) has undergone two separate allopolyploidization events, providing ideal model studying changes during events. In this study, we performed high-throughput sequencing of roots leaves from species with varied...
Nucleoside modified mRNA combined with Acuitas Therapeutics’ lipid nanoparticles (LNPs) has been shown to support robust humoral immune responses in many preclinical animal vaccine studies and later humans the SARS-CoV-2 vaccination. We recently showed that this platform is highly inflammatory due LNPs’ ionizable component. The property key development of potent responses. However, mechanism by which drives T follicular helper (Tfh) cells remains unknown. Here we show lack Langerhans or...
Hundreds of millions SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding the immune effects this platform. The mRNA-LNP-based is highly inflammatory, and its synthetic ionizable lipid component responsible for induction inflammation has long in vivo half-life. Since chronic can lead exhaustion non-responsiveness, sought determine pre-exposure on adaptive responses innate fitness. We found that mRNA-LNPs or LNP alone led...
Dendritic cells (DCs) are key regulators of adaptive immunity, guiding T helper (Th) cell differentiation through antigen presentation, co-stimulation, and cytokine production. However, in steady-state conditions, certain DC subsets, such as Langerhans (LCs), induce follicular (Tfh) B responses without inflammatory stimuli. Using multiple mouse models vitro systems, we investigated the mechanisms underlying LC-induced immune responses. We found that LCs drive germinal center Tfh antibody...
This study aimed to explore the neuroimaging basis of motor imagery (MI) in stroke rehabilitation, particularly focusing on brain activation patterns during MI tasks. Additionally, this may provide insights into clinical rehabilitation strategies. A total 40 right-handed patients from Zhejiang Rehabilitation Medical Center were assigned either right-sided or left-sided cerebral infarction group. They and recruited Center. portable near-infrared function imaging system was used detect changes...
Neuronal differentiation is tightly regulated by a variety of factors. In search for neuron-specific genes, we identified highly conserved novel zinc finger protein, ZNF536. We observed that ZNF536 most abundant in the brain and, particular, expressed developing central nervous system and dorsal root ganglia localized cerebral cortex, hippocampus, hypothalamic area. During neuronal P19 cells induced retinoic acid (RA), expression increased at an early stage, it maintained constant level...
Abstract Vaccines based on mRNA-containing lipid nanoparticles (LNPs) are a promising new platform used by two leading vaccines against coronavirus disease in 2019 (COVID-19). Clinical trials and ongoing vaccinations present with very high protection levels varying degrees of side effects. However, the nature reported effects remains poorly defined. Here we evidence that LNPs many preclinical studies highly inflammatory mice. Intradermal injection these led to rapid robust responses,...
In this paper, a novel miniature-step mobile robot with three degrees of freedom (DOFs) is developed based on the inchworm principle. This device, driven by piezo stack actuator, utilizes rhombic flexure hinge mechanism and four electromagnetic legs to achieve large stroke translation rotation high resolution platform. The design process flexible frame described. electric circuits for generating appropriate voltage signals are designed control clamp release from order investigate motion...