A5074495825- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Corneal surgery and disorders
- Pluripotent Stem Cells Research
- Rangeland Management and Livestock Ecology
- Peptidase Inhibition and Analysis
- Long-Term Effects of COVID-19
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Photoacoustic and Ultrasonic Imaging
- Corneal Surgery and Treatments
- Ultrasound and Hyperthermia Applications
- Lung Cancer Diagnosis and Treatment
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Ureteral procedures and complications
- ATP Synthase and ATPases Research
- Cancer Genomics and Diagnostics
- 14-3-3 protein interactions
- Anorectal Disease Treatments and Outcomes
- Genetics, Aging, and Longevity in Model Organisms
- Metallurgy and Material Science
- Pain Management and Opioid Use
- Autophagy in Disease and Therapy
- Neuropeptides and Animal Physiology
- Regional Development and Environment
Hubei Provincial Women and Children's Hospital
2024-2025
Harvard University
2024
Boston Children's Hospital
2024
Dalian Medical University
2017-2024
Chongqing Medical University
2017-2024
Second Affiliated Hospital of Chongqing Medical University
2017-2024
Zhejiang Cancer Hospital
2017-2022
University of Chinese Academy of Sciences
2017-2022
Cancer Hospital of Chinese Academy of Medical Sciences
2022
Tongji University
2021
Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 liver cancer tissues and negative correlation between expression patient survival. Furthermore, depletion dramatically reduced cell proliferation tumorigenesis, indicating oncogenic role progression. Moreover, identified acetylation at K323 site as regulatory mechanism for promoting its enzymatic activity metabolism. And further...
The current outbreak of coronavirus disease 2019 (COVID-19) has been defined as a pandemic by the World Health Organization. We aimed to evaluate clinical features and virological course non-severe COVID-19 patients with or without symptoms who were admitted Chinese cabin hospital. In this retrospective single center study, we reviewed 252 laboratory-confirmed treated at one temporary hospital in Wuhan, China. Demographic, clinical, serial chest computed tomography (CT), viral test data...
Metastasis is the dominant cause of patient death in small-cell lung cancer (SCLC), and a better understanding molecular mechanisms underlying SCLC metastasis may potentially improve clinical treatment. Through genome-scale screening for key regulators mouse Rb1-/- Trp53-/- using pooled CRISPR/Cas9 library, we identified Cullin5 (CUL5) suppressor cytokine signaling 3 (SOCS3), two components Cullin-RING E3 ubiquitin ligase complex, as top candidates. Mechanistically, deficiency CUL5 or SOCS3...
AIM: To evaluate the possible differences in visual quality between small incision lenticule extraction (SMILE) and femtosecond laser situ keratomileusis (FS-LASIK) for myopia. METHODS: A Meta-analysis was performed. Patients were from previously reported comparative studies treated with SMILE versus FS-LASIK. The PubMed, EMBASE, Cochrane, Web of Science Chinese databases (i.e. WANFANG CNKI) searched Nov. 2016 using RevMan 5.1 version software. acuity, aberration biomechanical effects within...
Urinary incontinence (UI) is commonly linked to pregnancy and obstetric factors, but the association between fetal birthweight maternal UI remains contentious. This study investigates its subtypes in Chinese primiparas. Cross-sectional data from 54,346 women aged 20 years above were obtained 2019–2021 National Incontinence Survey. Restricted cubic spline (RCS) regression analysis threshold effect used explore urinary subtypes. Among 19,365 primiparas, prevalence of was 14.5%. Adjusted...
Urinary incontinence (UI) is a disease that quietly yet seriously impacts women's health and represents global burden often neglected. This study aims to systematically assess the prevalence dynamics of female UI in China, can inform further policies have international implications. used three nationwide investigations: A national cross-sectional survey 2021; another 2006; data regarding institutions physicians providing pelvic floor rehabilitation services from 2005 2019. The weighted its...
To investigate whether α B-crystallin protects against acute retinal ischemic reperfusion injury (I/R) and elucidate the potential antioxidant mechanisms. Retinal I/R was made by elevating intraocular pressure (IOP) 110 mmHg for 60 min, (1 × 10 −5 g/L) or vehicle solution administered intravitreously immediately after injury. The animal sacrificed 24 h, 1 w, m retina damage detected hematoxylin eosin (HE) staining electroretinography (ERG). level of malondialdehyde (MDA), nitric oxide (NO),...
The present paper describes the molecular mechanism of diosgenin on tumor microenvironment angiogenesis and regulation GRP78 in signaling pathway. CCK8 method was used to evaluate effect different concentrations HUVEC activity hypoxic microenvironment. Apoptosis detected by Annexin V/PI staining. Tube Formation experiment conducted angiogenesis. Western Blot assay applied detect expressions phosphorylation levels angiogenesis-related pathways HIF-1α, GRP78, VEGF/VEGFR, PI3K/AKT, ERK, FAK...
p62/SQSTM1 (sequestosome-1) is a key protein involved in multiple cellular bioprocesses including autophagy, nutrient sensing, cell growth, death, and survival. Therefore, it implicated human diseases such as obesity cancer. Here, we show that the CUL5–ASB6 complex ubiquitin E3 ligase mediating p62 ubiquitination degradation. Depletion of CUL5 or ASB6 induced accumulation, overexpression promoted degradation p62. Functionally, can inhibit proliferation MEF hepatocellular carcinoma cells by...
Abstract Mechanisms of cell fate specification remain a central question for developmental biology and regenerative medicine. The pioneer factor ETV2 is master regulator the endothelial (EC) lineage specification. Here, we studied mechanisms ETV2-driven using highly efficient system in which directs human induced pluripotent stem cell-derived mesodermal progenitors to form ECs over two days. By applying CUT&RUN, single-cell RNA-sequencing (scRNA-seq) assay transposase-accessible...
To explore the clinical efficacy of modified limbal stem cell transplantation(Modified LSC transplantation) and bandage contact lens(BCL) implantation in pterygium surgery. A total 479 patients with primary who were admitted to our hospital from March 2019 2023 randomly divided into three groups: normal group (Group A: 89 patients), control B: 195 C: patients). Each received different intervention measures. Group did not undergo surgical treatment required follow up as outpatients. B...
Lin28a, originally discovered in the nematode Caenorhabditis elegans and highly conserved across species, is a well characterized regulator of let-7 microRNA (miRNA) implicated cell proliferation pluripotency control. However, little known about how Lin28a function modulated at post-translational level thereby responds to major signaling pathways. Here we show that directly phosphorylated by ERK1/2 kinases Ser-200. By editing lin28a gene with CRISPR/Cas9-based method, generated P19 mouse...
Purpose: To investigate the effect of β-elemene on bone cancer-related pain (BCRP) and its underlying mechanism in a rat model.Methods: A model BCRP was established by injection Walker 256 cells into medullary cavity adult male Sprague-Dawley rats. The effects pain-related behaviours were assessed paw withdrawal mechanical threshold (PWMT) thermal latency (PWTL). Quantitative real-time polymerase chain reaction (qRT-PCR) western blotting used to analyse transcription translation levels...
Opioid-tolerant patients are more likely to deviate from recommended treatments and experience inadequate analgesia than opioid-naive ones. The aim of this study was examine whether pharmacist-led management could help improve treatment adherence quality life. Eligible were randomized in a 1:1 ratio control group intervention group. received routine education support, while the additional individualized care. primary endpoint per-protocol analysis, as evaluated by blinded assessors. An...
Encroachment of woody plants into grasslands is a global phenomenon that has substantial impacts on pastoral productivity and ecosystem services. Over the past half century, pastoralists land management agencies have explored various options to control in order improve services shrub‐encroached grasslands. We examined effectiveness controlling encroachment shrub Caragana microphylla grassland Inner Mongolia, China. cut removed all aboveground biomass from 450 shrubs, predicting this...
Abstract: The global incidence and mortality rates of lung cancer are the highest any cancer. Small-cell (SCLC) is an undifferentiated carcinoma which accounts for 15–20% all cancers. Compared with other major type, non-small cell cancer, SCLC exhibits worse biological behavior, has a higher degree malignancy, develops more rapidly. majority present extensive-stage disease, prognosis these patients remains poor. Recently, immunotherapy been demonstrated clinical activity in (ES-SCLC);...
Improving morphine tolerance (MT) is an urgent problem in the clinical treatment of bone cancer pain. Considering that β-Elemene widely used pain, we explored effects and mechanism preventing MT pain.Bone pain chronic rat model was established by injecting MADB106 cells (10 mg/kg). SH-SY5Y were treated with μg/mL) for 48 h to establish a cell model. The mechanical withdrawal threshold thermal latency rats detected allodynia hyperalgesia tests, respectively. protein expressions μ-opioid...
Background: 2019 novel coronavirus disease (COVID-19) has been characterized as a pandemic by WHO. Clinical and virological course of patients with severe status have reported, but the data are little about non-severe patients. Methods: In this retrospective single center study, we include 252 inpatients laboratory confirmed COVID-19 treated in one temporary cabin hospital Wuhan, China. Demographic, clinical, serial chest CT outcome viral test were compared between asymptomatic mildly...