A5101635859- Retinoids in leukemia and cellular processes
- Wheat and Barley Genetics and Pathology
- Heat shock proteins research
- Chromosomal and Genetic Variations
- Effects and risks of endocrine disrupting chemicals
- Inflammasome and immune disorders
- Microtubule and mitosis dynamics
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Plant Disease Resistance and Genetics
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- interferon and immune responses
- Insect-Plant Interactions and Control
- Protist diversity and phylogeny
- Insect and Pesticide Research
- Estrogen and related hormone effects
- Genetics and Plant Breeding
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Cellular transport and secretion
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Crop Yield and Soil Fertility
- Cancer-related molecular mechanisms research
China Agricultural University
2020-2023
Yidu Central Hospital of Weifang
2019-2020
Nanjing University of Science and Technology
2018-2019
Heat stress greatly threatens crop production. Plants have evolved multiple adaptive mechanisms, including alternative splicing, that allow them to withstand this stress. However, how splicing contributes heat responses in wheat (Triticum aestivum) is unclear. We reveal the shock transcription factor gene TaHSFA6e alternatively spliced response generates two major functional transcripts: TaHSFA6e-II and TaHSFA6e-III. TaHSFA6e-III enhances transcriptional activity of three downstream protein...
Bisphenol A (BPA) and its replacement analog, bisphenol S (BPS), have been proposed as environmental obesogen to disrupt the lipid metabolism through regulating peroxisome proliferator-activated receptor gamma (PPARγ) receptor. However, there is a dearth of information on whether this biological effect can occur in human macrophage, cell type which closely interacts with adipocytes hepatocytes control metabolism. Here, we for first time investigate activity BPA BPS PPARγ pathway macrophages....
Heat stress is a major limiting factor for global wheat production and causes dramatic yield loss worldwide. The TaMBF1c gene upregulated in response to heat wheat. Understanding the molecular mechanisms associated with responses will pave way improve thermotolerance. Through CRISPR/Cas9-based editing, polysome profiling coupled RNA-sequencing analysis, protein-protein interactions, we show that conferred via regulating specific translation results showed evolutionarily conserved diploid,...
Alternative splicing (AS) occurs extensively in eukaryotes as an important mechanism for regulating transcriptome complexity and proteome diversity, but variation the AS landscape response to domestication polyploidization crops is unclear. Hexaploid wheat (AABBDD, Triticum aestivum) has undergone two separate allopolyploidization events, providing ideal model studying changes during events. In this study, we performed high-throughput sequencing of roots leaves from species with varied...
Endoplasmic reticulum (ER) stress contributes to the development and progression of many chronic inflammatory diseases, including type 2 diabetes, obesity, atherosclerosis, neurodegenerative cancer. ER has been reported induce inflammasome activation release mature IL-1β, which diseases. The molecular mechanisms that activate during are still poorly understood. Here we report kinase receptor-interacting protein 1 (RIP1) plays an important role in stress-induced inflammasome. Inhibition RIP1...
Lung cancer is the leading cause of cancer-related death, and adenocarcinoma most common histological type lung cancer.Syntaxin-binding protein 1 (STXBP1) essential for exocytosis secretory vesicles.Since basic cellular process cells, we investigated STXBP1 expression clinical significance in adenocarcinoma.We performed quantitative real-time polymerase chain reaction 20 pairs paired normal tissues, demonstrated that relative levels mRNA was significantly higher than those tissues.We then...
The aberrant expression of microRNAs (miRs) may be involved in tumor growth and progression human non-small cell lung carcinoma (NSCLC). present study aimed to investigate the potential roles miR-191 NSCLC. Western blotting reverse transcription-quantitative polymerase chain reaction were performed assess protein and/or mRNA levels. Scratch wound healing transwell assays determine NSCLC migration invasion. A luciferase demonstrated that CCAAT/enhanced binding β (C/EBPβ) was a target miR-191....
Objective: To determine the anti-tumor effects of 13-cis-retinoic acid (13cRA) combined with interferonα-2b (IFNα-2b) in mantle cell lymphoma (MCL) animal model. Methods: The model MCL was established by introducing Jeko-1 line into severe immunodeficiency disease mice. successfully tumor-developed mice were assigned to different groups treated negative control group (solvents), 13cRA (high dose: 200mg/kg; middle 100mg/kg; low 50 mg/kg) alone, IFNα-2b alone or combination dose IFNα-2b, and...
Objectives: To explore the effects of 13-cis-retinoic acid (13cRA) alone or combined with interferonα-2b (IFNα-2b) for inhibition cell growth and apoptosis induction mantle lymphoma lines Jeko-1 cells. Methods: cells were treated by different concentrations 13cRA IFN-α2b. CCK-8 was used to measure treatments. Cell cycles analyzed flow cytometry. Effects on assessed staining Annexin Ⅴ/PI. And levels Cyclin D1, caspase-9 Rb proteins measured Western blot method. Results: at doses its...