A5007583142- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Neuroscience and Neuropharmacology Research
- Metastasis and carcinoma case studies
- Endoplasmic Reticulum Stress and Disease
- Advanced biosensing and bioanalysis techniques
- Electrochemical sensors and biosensors
- Connexins and lens biology
- Colorectal Cancer Surgical Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Analytical chemistry methods development
- Inflammatory mediators and NSAID effects
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Analytical Chemistry and Sensors
- Synthesis and biological activity
- RNA modifications and cancer
- Circular RNAs in diseases
- Advanced Chemical Sensor Technologies
- Cancer-related molecular mechanisms research
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Bioactive Compounds and Antitumor Agents
Nanjing Drum Tower Hospital
2013-2025
The First People's Hospital of Changde
2025
Fudan University
2025
Regend Therapeutics (China)
2024
Institute of Archaeology
2024
Sun Yat-sen University
2019-2023
Nanjing University of Chinese Medicine
2023
Nanjing Medical University
2017-2023
Nanjing University
2013-2023
Bridge University
2021
Abstract Aim Hepatic tissue engineering is considered as a possible alternative to liver transplantation for end‐stage disease. Several methods of decellularization xenogeneic are available produce three‐dimensional organ scaffolds tissues. However, rare studies have examined and compared the effectiveness different on structure composition intact decellularized extracellular matrix. Methods Two were adopted herein. Their effects collagen, elastin, glycosaminoglycans ( GAG s), hepatocyte...
Oral administration of probiotics orchestrates the balance between intestinal microbes and immune response. However, effective delivery in situ colonization are limited by harsh environment gastrointestinal tract. Herein, we provide a microfluidics-derived encapsulation strategy to address this problem. A novel synergistic system composed EcN Nissle 1917 prebiotics, including alginate sodium inulin gel, for treating inflammatory bowel disease colitis-associated colorectal cancer is proposed....
The phase II JO25567 study compared the efficacy and safety of erlotinib plus bevacizumab vs. alone as first-line therapy for advanced epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (NSCLC).Our objective is to provide updated analyses assessment manageability specific adverse events.Patients with stage IIIB/IV or recurrent, non-squamous, EGFR NSCLC were randomized receive erlotinib. primary endpoint was progression-free survival. Adverse event frequency...
Patients with non-small-cell lung cancer (NSCLC) frequently develop radioresistance, resulting in poor response to radiation and unfavourable prognosis. Early detection of radioresistance hence can guide the adjustment treatment regimens time. Exosomes are lipid bilayer-enclosed vesicles sub-micrometer size that released by various cells. contain a tissue-specific signature wherein variety proteins nucleic acids selectively packaged. Growing evidence shows exosomes involved pathophysiology...
Objectives The aim of this study is to derive and validate a reliable indicator for predicting an increased risk postoperative mortality in elderly patients undergoing curative resection colorectal cancer (CRC). Design This multicentre retrospective design. Setting participants A total 1227 CRC (age ≥65 years) from three distinct cohorts were enrolled. Participant consisted the derivation (n=845), external validation (n=95) localised (n=287) groups. carcinoembryonic antigen (CEA) lymphocyte...
Objective: To explore the clinical application value of transoral robotic surgery (TORS) in treatment tonsil squamous cell carcinoma (TSCC). Methods: A retrospective analysis was conducted. The data 157 TSCC patients were collected who received TORS at five medical centers, namely Sun Yat-sen University Cancer Center, Memorial Hospital, Eye Ear Nose and Throat Hospital Fudan University, First Affiliated China Medical Tongji College, from 1 January 2017 to 31 July 2022. There 130 males 27...
The potentiation of glycine-induced responses by ethanol (EtOH) was studied in neurons freshly dissociated from the ventral tegmental area (VTA) 5- to 14-day-old postnatal rats using whole-cell and gramicidin-perforated patch-clamp techniques. Under current-clamp conditions, EtOH increased membrane depolarization action potential firing. voltage-clamp (0. 1-40 mM) alone did not elicit a current. When coapplied with glycine, enhanced current 35% (180 474) neurons. EtOH-induced enhancement...
Three-dimensional (3D) reconstruction and rapid prototyping technology (RPT) of multislice spiral computed tomography angiography (CTA) was applied to prepare physical models the heart ventricular septal defects tetralogy Fallot (ToF) patients in order explore their applications diagnosis treatment this complex disease.CTA data 35 ToF were collected l:l 3D solid using digital RPT, resultant used intraoperatively as reference.The operations all completed under guidance model, without...
Hepatic carcinoma is one of the most common cancers in world, with a high incidence. Emodin an anthraquinone derived from Polygonum multiflorum Thunb, possessing anti-cancer activity. The purpose this study to investigate effect different dosages emodin on HepG2 cells using 1H NMR based metabolic approach complemented qRT-PCR and flow cytometry identify potential markers discover targets explore underlying mechanism. can dose-dependently inhibit growth cells, perturb cell cycle progression,...
Carbohydrate antigen 125 (CA125) is elevated as a tumor marker in many carcinomas, but its association with gastrointestinal stromal (GIST) has received less attention. This study intends to evaluate whether CA125 level can predict progression and overall survival (OS) of GIST patients.We retrospectively analyzed the clinical data follow-up records patients who underwent surgical resection Nanjing Drum Tower Hospital from August 2010 December 2020. All were classified according serum level....
In this work, a multifunctional drug delivery system was developed for potential application in NIR fluorescence imaging and targeting PDT.
// Qiang Li 1, * , Xuefeng Xia Jie Ji 2 Jianghui Ma 1 Liang Tao Linjun Mo 3 Wei Chen 4 Department of General Surgery, The Afflicted Drum Tower Hospital Nanjing University Medical School, Nanjing, China Nangjing University, Nangjing, School Western Australia, and Australia Liver Kidney Surgical Transplant Service, Sir Charles Gairdner Hospital, Perth, Institute Molecular Engineering, Chicago, Illinois, USA These authors contributed equally to this work share the first authorship...
Endoplasmic reticulum (ER) stress contributes to the development and progression of many chronic inflammatory diseases, including type 2 diabetes, obesity, atherosclerosis, neurodegenerative cancer. ER has been reported induce inflammasome activation release mature IL-1β, which diseases. The molecular mechanisms that activate during are still poorly understood. Here we report kinase receptor-interacting protein 1 (RIP1) plays an important role in stress-induced inflammasome. Inhibition RIP1...
Abstract Photothermal therapy (PTT) is an emerging noninvasive and precise localized therapeutic modality; however, it deeply limited by its poor tumor accumulation, inadequate photothermal conversion efficiency, the thermoresistance of cancer cells. Aimed at these shortcomings, tumor‐targeting nanoparticles (iRGD‐W 18 O 49 ‐17AAG) comprising carboxyl‐group‐functionalized W nanoparticles, integrin‐targeting peptide iRGD, HSP90‐inhibitor 17AAG are developed. The act as excellent PTT carriers...