A5100377666- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Pharmacological Receptor Mechanisms and Effects
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Navier-Stokes equation solutions
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Neurotransmitter Receptor Influence on Behavior
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Nanoplatforms for cancer theranostics
- Nuclear Receptors and Signaling
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
Xuzhou Medical College
2014-2025
Soochow University
2015-2025
Hunan University of Arts and Science
2025
First Affiliated Hospital of Soochow University
2023-2025
Shanghai University
2025
Chinese Academy of Sciences
2009-2024
China Pharmaceutical University
2016-2024
Jiangnan University
2021-2024
Institute of Zoology
2024
State Key Laboratory of Membrane Biology
2024
Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the gastrointestinal tract in response to food intake. It enhances pancreatic islet beta-cell proliferation and glucose-dependent insulin secretion, lowers blood glucose intake patients with type 2 diabetes mellitus (T2DM). A long-acting GLP-1 receptor (GLP-1R) agonist, exendin-4 (Ex-4), first of this new class antihyperglycemia drugs approved treat T2DM. GLP-1Rs are coupled cAMP second messenger pathway...
Glucocorticoids play an important biphasic role in modulating neural plasticity; low doses enhance plasticity and spatial memory behavior, whereas chronic, higher produce inhibition. We found that 3 independent measures of mitochondrial function-mitochondrial oxidation, membrane potential, calcium holding capacity-were regulated by long-term corticosterone (CORT) treatment inverted "U"-shape. This regulation function CORT correlated with neuroprotection; is, had a neuroprotective effect,...
In this manuscript we report that human embryonic stem cells (hESCs) differentiated into dopaminergic neurons when cocultured with PA6 cells. After 3 weeks of differentiation, approximately 87% hES colonies contained tyrosine hydroxylase (TH)-positive cells, and a high percentage the in most expressed TH. Differentiation was inhibited by exposure to BMP4 or serum. TH-positive derived from hESCs were postmitotic, as determined bromodeoxyurindine colabeling. Differentiated other markers...
Abstract Background The Perceived Stress Scale (PSS) is a globally used and self-report scale measuring perceived stress. Three versions of PSS (PSS-14, PSS-10 PSS-4) are available which comprise 14, 10 4 items respectively. However, the Chinese version has not yet been validated in large community-based general population. aims this study were to evaluate psychometric properties population compare appropriateness three PSS. Methods A total 9507 adults with at least junior high school...
Hydrogen therapy, an emerging therapeutic strategy, has recently attracted much attention in anticancer medicine. Evidence suggests that hydrogen (H2) can selectively reduce intratumoral overexpressed hydroxyl radicals (•OH) to break the redox homeostasis and thereby lead stress cell damage. However, inability achieve stable storage efficient delivery hinders development of therapy. Furthermore, oxygen (O2) deficiency tumor microenvironment (TME) electron-hole separation inefficiency...
Of the six fatty acid elongase (Elovl) subtypes expressed in mammals, adult rat liver expresses four subtypes: Elovl-5 > Elovl-1 = Elovl-2 Elovl-6. Overnight starvation and fish oil-enriched diets repressed hepatic activity livers of male rats. Diet-induced changes correlate with Elovl-6 mRNA abundance. Adult rats fed peroxisome proliferator-activated receptor alpha (PPARalpha) agonist WY14,643 have increased activity, Elovl-1, Elovl-5, Elovl-6, Delta5, Delta6, Delta9 desaturase abundance,...
Down-regulation of miR-138 (microRNA-138) has been frequently observed in various cancers, including HNSCC (head and neck squamous cell carcinoma). Our previous studies suggest that down-regulation is associated with mesenchymal-like morphology enhanced migration invasion. In the present study, we demonstrated these miR-138-induced changes were accompanied by marked reduction E-cad (E-cadherin) expression Vim (vimentin) expression, characteristics EMT (epithelial–mesenchymal transition). On...
Long-term depression (LTD) induced by low-frequency synaptic stimulation (LFS) was originally introduced as a model to probe potential mechanisms of deprivation-induced in visual cortex. In hippocampus, LTD requires activation postsynaptic NMDA receptors, PKA, and the clathrin-dependent endocytosis α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. It has long been assumed that cortical layer 2/3 LFS 4 uses similar mechanisms. Here we show mouse cortex this conclusion...
Accumulating evidence suggests that mitochondrial dysfunction plays a critical role in the progression of variety neurodegenerative and psychiatric disorders. Thus, enhancing function could potentially help ameliorate impairments neural plasticity cellular resilience associated with neuropsychiatric A series studies was undertaken to investigate effects mood stabilizers on function, against mitochondrially mediated neurotoxicity. We found long-term treatment lithium valproate (VPA) enhanced...
Sigma-1 receptors (Sig-1Rs) are endoplasmic reticulum (ER)-resident proteins known to be involved in learning and memory. Dendritic spines hippocampal neurons play important roles neuroplasticity This study tested the hypothesis that Sig-1Rs might regulate denritic spine formation examined potential mechanisms therein. In rat primary neurons, knockdown of by siRNAs causes a deficit dendritic is unrelated ER Ca(2+) signaling or apoptosis, but correlates with mitochondrial permeability...
The interactions between microorganisms driven by substrate metabolism and energy flow are important to shape diversity, abundance, structure of a microbial community. Single cell technologies useful tools for dissecting the functions individual members their in communities. Here, we developed novel Raman stable isotope probing (Raman-SIP), which uses microspectroscopy coupled with reverse D2O colabeling study metabolic two-species community consisting Acinetobacter baylyi ADP1 Escherichia...
Dysregulated microRNAs (miRNAs) play an important role in osteosarcoma (OS) progression. In the present study, we investigate clinical significance of serum miR-491 level and potential OS lung metastasis chemoresistance. Clinical data show that was decreased from patients compared with healthy control subjects, a is correlated increased metastasis, poor chemoresponse, lower survival rate patients. vitro vivo experiments overexpression suppresses cell whereas it enhances cisplatin...
Abstract Background Hippocampal damage caused by status epilepticus (SE) can bring about cognitive decline and emotional disorders, which are common clinical comorbidities in patients with epilepsy. It is therefore imperative to develop a novel therapeutic strategy for protecting hippocampal after SE. Mitochondrial dysfunction one of contributing factors Given the benefits mitochondrial replenishment exogenous mitochondria, we hypothesized that transplantation mitochondria would be capable...
Abstract In the era of ubiquitous computing with flourished visual displays in our surroundings, application haptic feedback technology still remains its infancy. Bridging gap between and real world to enable ambient on various physical surfaces is a grand challenge field human-computer interaction. This paper presents concept an active electronic skin, characterized by three features: richness (multi-modal stimuli), interactivity (bi-directional sensing actuation capabilities), invisibility...