A5101876895- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Skin Protection and Aging
- Lung Cancer Diagnosis and Treatment
- Lymphatic System and Diseases
- Advanced Photocatalysis Techniques
- Advanced Nanomaterials in Catalysis
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Esophageal Cancer Research and Treatment
- Nanoparticle-Based Drug Delivery
- Natural Compounds in Disease Treatment
- Metabolomics and Mass Spectrometry Studies
- Cancer-related Molecular Pathways
- Hedgehog Signaling Pathway Studies
- Photodynamic Therapy Research Studies
- Digestive system and related health
- RNA Research and Splicing
Wenzhou Medical University
2024
Xuzhou Medical College
2022-2023
University of Chinese Academy of Sciences
2021
University of South Carolina Sumter
2021
Soochow University
2020
First Affiliated Hospital of Soochow University
2020
Zhoushan Hospital
2020
First Affiliated Hospital of Xi'an Jiaotong University
2019
Hydrogen therapy, an emerging therapeutic strategy, has recently attracted much attention in anticancer medicine. Evidence suggests that hydrogen (H2) can selectively reduce intratumoral overexpressed hydroxyl radicals (•OH) to break the redox homeostasis and thereby lead stress cell damage. However, inability achieve stable storage efficient delivery hinders development of therapy. Furthermore, oxygen (O2) deficiency tumor microenvironment (TME) electron-hole separation inefficiency...
Abstract Caudal-related homeobox transcription factor 2 (CDX2), an intestine-specific nuclear factor, has been strongly implicated in the tumourigenesis of various human cancers. However, functional role CDX2 development and progression colorectal cancer (CRC) is not well known. In this study, knockdown colon cells promoted cell proliferation vitro, accelerated tumor formation vivo, induced a cycle transition from G0/G1 to S phase, whereas overexpression inhibited proliferation....
Ovarian cancer is a highly lethal gynecological malignancy, emphasizing the need for effective treatment strategies. This study investigated synergistic effects of quercetin and paclitaxel on ovarian cancer. Using SKOV3 A2780 cell lines, we found that combined significantly enhanced apoptosis inhibited invasion migration compared to individual treatments. Then, identified 32 common targets between quercetin/paclitaxel cancer, with 29 genes showing differential expression normal tissue tumor...
Background: Photodynamic therapy increases collagen and decreases solar fibrosis in photoaged skin; however, the efficacy of photodynamic is limited tissues with a hypoxic microenvironment. Methods: A novel autogenous oxygen-targeted nanoparticle, named MCZT, was synthesized based on zeolitic imidazole framework material ZIF-8, methyl aminolevulinate, catalase an anti-TRPV1 monoclonal antibody, its effects skin photoaging were investigated. Results: MCZT successfully showed uniform particle...
The present study aimed to investigate the roles of cancer-associated fibroblasts (CAFs), matrix metalloproteinase-9 (MMP-9) and lymphatic vessel density (LVD) during progression from adenocarcinoma in situ (AIS) invasive lung (IAC). A total 77 patients with stage 0-IA were enrolled. expression levels α-smooth muscle actin, MMP-9 D2-40 immunohistochemically analyzed. Survival analysis was performed using Kaplan-Meier method. In non-invasive component, proportion CAFs increased AIS IAC;...
Triptolide (TPL) is a small molecule isolated from traditional Chinese herb Tripterygium wilfordii Hook F and shows excellent anticancer effect for pancreatic cancer cells. However, the poor water solubility ad severe liver toxicity of TPL hindered its clinical application. Herein, covalently conjugated to polymer entrapped inside core nanogel (nTPL) protect it premature leakage during blood circulation. With help lactobionic acid (LBA), nTPL‐LBA could selectively target tumors in an...
Abstract Aim The purpose of this research was to evaluate lncRNA FEZF1‐AS1 in cervical cancer development and clinical significance. Materials methods Collecting tissues, measuring expression, analysis correlation between prognosis. In cell vitro study, using MTT assay measure proliferation, evaluating apoptosis by flow cytometry, invasion migration Transwell wound healing assay; miR‐1254 gene expressions were evaluated RT‐qPCR relative protein (Smurf1, E‐cadherin, Vimentin, N‐cadherin, AKT,...