A5101894014- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Nanoplatforms for cancer theranostics
- Radical Photochemical Reactions
- Synthesis and Catalytic Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Nanocluster Synthesis and Applications
- Crystal structures of chemical compounds
- Polymer composites and self-healing
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Advancements in Battery Materials
- biodegradable polymer synthesis and properties
- Electrospun Nanofibers in Biomedical Applications
- Magnetism in coordination complexes
- Natural Compounds in Disease Treatment
- Covalent Organic Framework Applications
- MicroRNA in disease regulation
- Congenital Heart Disease Studies
- Axon Guidance and Neuronal Signaling
- Hedgehog Signaling Pathway Studies
- Apelin-related biomedical research
- Supramolecular Chemistry and Complexes
- Medicinal Plant Pharmacodynamics Research
- Gas Sensing Nanomaterials and Sensors
Affiliated Hospital of Qingdao University
2025
Qingdao University
2025
Xuzhou Medical College
2025
Children's Hospital of Zhejiang University
2015-2025
Hefei Normal University
2023-2024
University of Jinan
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
China United Network Communications Group (China)
2024
State Key Laboratory of Cardiovascular Disease
2024
National Clinical Research Center for Digestive Diseases
2024
The catalytic C(sp3)–H functionalization is highly desirable yet challenging in organic synthesis. Incorporation of the SP(O)(OR)2 group through remains unexplored. We herein report an unprecedented protocol for phosphorothiolation primary and secondary via a multicomponent reaction with N-fluoro-substituted amides, elemental sulfur, P(O)H compounds involving sequence amidyl radical generation, 1,5-HAT, Cu-catalyzed cross coupling resulting carbon (RO)2P(O)SH (generated situ).
Abstract Photothermal therapy (PTT) has attracted tremendous attention due to its noninvasiveness and localized treatment advantages. However, heat shock proteins (HSPs) associated self‐preservation mechanisms bestow cancer cells thermoresistance protect them from the damage of PTT. To minimize improve efficacy PTT, an integrated on‐demand nanoplatform composed a photothermal conversion core (gold nanorod, GNR), cargo HSPs inhibitor (triptolide, TPL), mesoporous silica based nanoreservoir,...
Abstract The biomimetic enzyme activity of cerium oxide nanoparticles (CeNPs) prefers ultrasmall particle size and bare surface. Unfortunately, those two features are not favorable for its in vivo application due to easy aggregation fast renal filtration. To take advantage the CeNP cancer therapy, a homologous targeted nanoparticle system, (T‐CeNP), with integration biodegradable dendritic mesoporous silica nanoparticle, superoxide dismutase catalase mimicking CeNPs, camouflage coating cell...
The first oxidative C(sp3)-H phosphonylation of tertiary aliphatic amines has been developed. use cobalt acetate as a catalyst, N-hydroxyphthalimide cocatalyst, and air an oxidant enabled the conversion aromatic into α-aminophosphonates in moderate to excellent yields under mild conditions via cross dehydrogenative coupling reaction.
Abstract Organothiophosphates have found widespread application as biologically active compounds and synthetic intermediates in medicinal chemistry. The first transition‐metal‐free one‐pot direct synthesis of heterocyclic phosphorothioates involving indole or imidazo[1,2‐a]pyridine derivatives, elemental sulfur, P(O)H is presented. use NaI KI a catalyst, tert ‐butyl hydroperoxide an oxidant, various derivatives are tolerant this transformation, affording the corresponding products good to...
This study aims to investigate the correlation between development of diabetic retinopathy (DR) and changes in corneal sub-basal nerve plexus (SNP) dendritic cells (DCs). 58 patients with type 2 diabetes mellitus (T2DM) 30 age- sex-matched healthy participants underwent assessment nerve. The DR group was divided into no (NDR) 29 eyes mild moderate non-proliferative (NPDR). We collected clinical data (gender, age, body mass index), laboratory indicators (fasting blood glucose, glycosylated...
Open-heart surgeries carry significantly greater risks in neonates than older children. The current study aimed to analyze the short-term outcomes and risk factors for mortality undergoing cardiac surgeries. This retrospective analysis included who underwent with cardiopulmonary bypass (CPB) at our center between 2019 2023. Perioperative operative were collected, in-hospital identified. We analyzed medical records of 190 neonates, including 111 males 79 females. median age time surgery was...
An ideal scaffold for bone tissue engineering should have interconnected porous structure, good biocompatibility, and mechanical properties well-matched with natural bones. Collagen is the key component in extracellular matrix (ECM) of bones, plays an important role regeneration. The biological activity collagen has promoted it to be advantageous biomaterial engineering; however, these scaffolds are insufficient structures not stable wet state. effective strategy solve this problem fabricate...
Herein, we describe the first example of copper-catalyzed oxidative thioamination maleimides with secondary amines and Bunte salts achievement C–N C–S bonds in a single flask. The protocol showcases prominently broad substrate scope is also efficient for late-stage modification an array pharmaceuticals. Preliminary mechanistic investigation indicates amination to form reactive enaminone subsequent intermolecular alkenyl C–H thiolation.
The involvement of several microRNAs (miRs) in the initiation and development tumors through suppression target gene expression has been highlighted. aberrant miR-181d-5p cyclin-dependent kinase inhibitor 3 (CDKN3) non-small-cell lung cancer (NSCLC) was then screened by microarray analysis. In present study, we performed a series vivo vitro experiments for purpose investigating their roles NSCLC underlying mechanism. There high CDKN3, whereas downregulated NSCLC. Quantitative RT-PCR, Western...
Early-stage brain metastasis of breast cancer (BMBC), due to the existence an intact blood-brain barrier (BBB), is one deadliest neurologic complications. To improve efficacy chemotherapy for BMBC, a Trojan horse strategy-based nanocarrier has been developed by integrating cell membrane brain-homing and polymeric drug depot. With camouflage MDA-MB-231/Br membrane, doxorubicin-loaded poly (D, L-lactic-co-glycolic acid) nanoparticle (DOX-PLGA@CM) shows enhanced cellular uptake boosted killing...
A photoredox-catalyzed cascade radical reaction of <italic>N</italic>-propargylindoles and sulfonyl chlorides to 2-sulfonated 9<italic>H</italic>-pyrrolo[1,2-<italic>a</italic>]indoles under external oxidant-free conditions was developed.
Anticancer drug-loaded nanoparticles have been explored extensively to decrease side effects while improving their therapeutic efficacy. However, due the low drug loading content, premature release, nonstandardized carrier structure, and difficulty in predicting fate of carrier, only a few nanomedicines approved for clincial use. Herein, carrier-free nanoparticle based on self-assembly curcumin-erlotinib conjugate (EPC) is developed. The EPC nanoassembly exhibits more potent cell killing,...
Incorporation of the (RO) 2 P(O)S group through unreactive C(sp 3 )–H phosphorothiolation remains a challenging area research.
The visible-light-driven switchable phosphorylation of cyanoaromatics with the 1,6-enyne moiety for diverse and selective synthesis phosphorylated polyheterocycles, including aminophosphonates, iminophosphonates, ketones, has been described. Importantly, these photocatalytic transformations feature good functional group tolerance high regio- chemoselectivities under mild reaction conditions. These findings might stimulate exploration new utilizations P(O)–H compounds by employing...
Herein, we report a photoredox/copper dual-catalyzed selective phosphorothiolation of propargylic derivatives from easily accessible [P(O)SH] compounds. This reaction provides general, mild and versatile procedure to synthesize variety synthetically useful
In article number 1908445, Yufeng Zhao and co-workers review the research progress with regards to electrode materials of organic sodium-ion batteries, ranging from small molecules polymers, a focus on molecular structure design/modification, electrochemical behavior, corresponding charge-storage mechanism.
Abstract A copper‐catalyzed oxidative carboamination of maleimides with alkyl amines and α‐bromo carboxylates is described. These multicomponent reactions show good functional group compatibility are suitable for the late‐stage modification a series neuroprotective agents, providing direct path library synthesis 3‐carbo‐4‐amino maleimides. The initial amination to form enamines intermediate, followed by radical alkylation carboxylate compounds, triggers relayed catalytic reaction achieve...