A5101754635- Sirtuins and Resveratrol in Medicine
- Plasma Applications and Diagnostics
- Phytochemistry and Biological Activities
- Analytical chemistry methods development
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Advanced Image Processing Techniques
- Cancer Immunotherapy and Biomarkers
- Fungal Biology and Applications
- Epigenetics and DNA Methylation
- Retinal Imaging and Analysis
- Atomic and Subatomic Physics Research
- Autophagy in Disease and Therapy
- Nicotinic Acetylcholine Receptors Study
- Abdominal Trauma and Injuries
- Platelet Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Advanced Image Fusion Techniques
- Medical Research and Treatments
- Ureteral procedures and complications
- Wound Healing and Treatments
- Isotope Analysis in Ecology
- Calcium signaling and nucleotide metabolism
- Mass Spectrometry Techniques and Applications
- Water Treatment and Disinfection
Shandong Provincial Hospital
2023-2025
Shandong University
2024-2025
Sichuan University
2024-2025
Second People Hospital of Hunan
2025
West China Hospital of Sichuan University
2024-2025
Zhejiang University of Technology
2022-2024
Peking University
2023-2024
First Affiliated Hospital of Henan University
2024
Shandong First Medical University
2023-2024
Yantai University
2024
Background: Identifying biomarkers that predict immunotherapy efficacy and discovering new targets for combination therapies are critical elements improving the prognosis of bladder cancer (BLCA) patients. Methods: Firstly, we explored expression patterns TBX3 in normal pan-cancer tissues correlation between immune microenvironment using data from multiple public databases. Then, combined various techniques, including bulk RNA sequencing, single-cell high-throughput cytokine arrays,...
This study aims to investigate the correlation between development of diabetic retinopathy (DR) and changes in corneal sub-basal nerve plexus (SNP) dendritic cells (DCs). 58 patients with type 2 diabetes mellitus (T2DM) 30 age- sex-matched healthy participants underwent assessment nerve. The DR group was divided into no (NDR) 29 eyes mild moderate non-proliferative (NPDR). We collected clinical data (gender, age, body mass index), laboratory indicators (fasting blood glucose, glycosylated...
COL4A5 gene variants could result in the X‐linked Alport syndrome 1, dominant inheritance (XLAS1) (Online Mendelian Inheritance Man (OMIM) #301050). The splicing changes can be identified through targeted RNA sequencing (RNA seq), but obtaining accessible patient samples from urine cells and skin fibroblasts is challenging. Moreover, extracted transcripts cannot amplified due to their nonexpression peripheral blood mononuclear (PBMCs). In study, we induced patient‐derived PBMCs differentiate...
Non-ionic surfactants (NISs) were used to improve the performance of dielectric barrier discharge plasma induced vapor generation (DBD plasma-CVG).
DICER1 syndrome (OMIM 601200) is a rare autosomal dominant familial tumor susceptibility disorder with heterozygous germline mutations. The most common in clinical practice pleuropulmonary blastoma. Pleuropulmonary blastoma pediatric lung that begins during fetal development and part of an inherited syndrome. We found patient performed whole-exome testing on him his parents. mutation located at gene, c. 1510-16G>A. tested person has variation this locus. person's father no locus, while the...
SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis many cancers, but their association with survival breast cancer has not determined. The purpose of this study was to assess the possible prognostic value SIRT1, N1IC, Snail patients.Immunohistochemistry performed examine Snail, combined using tissue microarrays containing matched adjacent normal from 150 patients. Survival analysis carried out Kaplan-Meier method. Univariate multivariate were used evaluate SIRT1/N1IC...
Fresh-cut Chinese water chestnuts (CWC) turn yellow after being peeled, reducing their shelf life and commercial value. Metabolomics, the systematic study of full complement small molecular metabolites, was useful for clarifying mechanism fresh-cut CWC etiolation developing methods to inhibit yellowing. In this study, metabolic alterations associated with at different growth stages (0 day, 2 days, 3 4 5 days) from were investigated using LC–MS analyzed by pattern recognition (principal...
Oncolytic virotherapy is emerging as a promising therapeutic avenue for cancer treatment, harnessing both innate and tumor-specific immune responses targeted tumor elimination. In this study, we present novel oncolytic virus (oHSV1-IL15B) derived from herpes simplex virus-1 (HSV-1), armed with IL-15/IL-15Rα complex, focus on treating colon combined HSV-1 expressing anti-PD-1 antibody (oHSV1-aPD1). Results our study reveal that recombinant oHSV-1 equipped complex exhibited significant...
Objectives: To compare treatment plans of intensity modulated radiotherapy (IMRT), volumetric arc (VMAT), and helical tomotherapy (HT) with simultaneous integrated boost (SIB) technique for esophageal cancer (EC) different locations using dosimetry radiobiology. Methods: Forty EC patients were planned IMRT, VMAT, HT plans, including 10 cases located in the cervix, upper, middle, lower thorax, respectively. Dose-volume metrics, conformity index (CI), homogeneity (HI), tumor control...
Histone lysine isonicotinylation (Kinic) induced by isoniazid (INH) was recently identified as a post-translational modification in cells. However, global cellular non-histone proteins Kinic remains unclear. Using proteomic technology, we 11,442 sites across 2,792 and demonstrated that of is involved multiple function pathways. Non-histone can be regulated isonicotinyl-transferases, including CBP Tip60, deisonicotinylases, HDAC8 HDAC6. In particular, the poly (ADP-ribose) (PAR) polymerase 1...
Three new cyathane diterpenoids named stercorins A-C (1-3), including one with unusual 4,9-seco-carbon skeleton, together two drimane sesquiterpenoids D (4) and E (5) were isolated from the liquid cultures of basidiomycete Cyathus stercoreus. Their structures established by 1D 2D NMR data in conjunction HR-ESI-MS. All three showed neurotrophic activity PC-12 cells at concentrations 10 µM. Compounds 1-3 significantly suppressed LPS-induced NO production culture medium BV2 IC50 values 1.64 μM,...
SIRT1 expression and Notch1 signaling have been implicated in tumorigenesis many cancers, but their association with survival breast cancer has not determined. The purpose of this study was to assess the possible prognostic value SIRT1, N1IC, Snail patients. Immunohistochemistry performed examine Snail, combined using tissue microarrays containing matched adjacent normal from 150 Survival analysis carried out Kaplan-Meier method. Univariate multivariate were used evaluate SIRT1/N1IC...
Abstract Vitamin B3 is the major precursor of NAD + and NADP , however it was unknown whether this vitamin supplementation could modify histone epigenetically. Here, we report nicotinic acid (NA), a component B3, suppresses liver cancer metastasis specifically, via stimulating lysine nicotinylation (Knic). Importantly, nicotinyl-CoA, that metabolically generated by NA ACSS2, stimulates Knic in vivo vitro . Histone regulates chromatin accessibility inhibits binding transcription factor HOXB9...