A5016214793- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Mycorrhizal Fungi and Plant Interactions
- Immune Cell Function and Interaction
- Carbohydrate Chemistry and Synthesis
- Plant Pathogens and Fungal Diseases
- T-cell and B-cell Immunology
- Phytochemistry and Bioactivity Studies
- Plant biochemistry and biosynthesis
- Chemical synthesis and alkaloids
- Phytochemistry and Biological Activities
- Biochemical and Molecular Research
- Monoclonal and Polyclonal Antibodies Research
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- Immunotherapy and Immune Responses
- Chemical Synthesis and Analysis
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- DNA Repair Mechanisms
- RNA modifications and cancer
- Phytochemicals and Antioxidant Activities
- Peptidase Inhibition and Analysis
- Seaweed-derived Bioactive Compounds
- Mycotoxins in Agriculture and Food
Northwest A&F University
2019-2025
Xi’an International University
2024-2025
Shaanxi University of Technology
2025
Northeast Forestry University
2022-2024
Northwest Institute of Mechanical and Electrical Engineering
2024
Shangluo University
2023-2024
Shaanxi Normal University
2019
Wuhan University
2007-2018
China National Hybrid Rice R&D Central Hunan Hybrid Rice Reserch Center
2015
Cytoplasmic male sterility (CMS) has been extensively used for hybrid seed production in many major crops. Honglian CMS (HL-CMS) is one of the three types rice and contributed greatly to food security worldwide. The HL-CMS trait associated with an aberrant chimeric mitochondrial transcript, atp6-orfH79, which causes pollen can be rescued by two nonallelic restorer-of-fertility (Rf) genes, Rf5 or Rf6. Here, we report identification Rf6, encodes a novel pentatricopeptide repeat (PPR) family...
Abstract Background Orsellinic acid (2,4-dihydroxy-6-methylbenzoic acid, OA) and its structural analog o -Orsellinaldehyde, have become widely used intermediates in clinical drugs synthesis. Although the research on biosynthesis of such compounds has made significant progress, due to lack suitable hosts, there is still far from industrial production based synthetic biology. Results With help genome mining, we found a polyketide synthase (PKS, HerA) Hericium erinaceus , which shares 60% amino...
Ophiocordyceps sinensis is a fungus that cultured through fermentation from wild Chinese cordyceps. While studies have examined its metabolites, the evaluation of antioxidant capacity remains to be conducted. The results O. indicate ferric ion-reducing power (FRAP), (2.74 ± 0.12 μmol Trolox/g), 2,2-diphenyl-1-picrylhydrazyl (DPPH•) free radical scavenging rate (60.21 0.51%), and hydroxyl (91.83 0.68%) reached maximum on day 30. Using LC-MS/MS measure metabolites D24, D30, D36, we found...
Inonotus obliquus is an important edible and medicinal mushroom that was shown to have many pharmacological activities in preclinical trials, including anti-inflammatory, antitumor, immunomodulatory, antioxidant effects. However, the biosynthesis of these components has rarely been reported. The lack genomic information hindered further molecular characterization this mushroom.In study, we report genome I. using a combined high-throughput Illumina NovaSeq with Oxford Nanopore PromethION...
Inonotus hispidus mushroom is a traditional medicinal fungus with anti-cancer, antioxidation, and immunomodulatory activities, it used in folk medicine as treatment for indigestion, cancer, diabetes, gastric illnesses. Although I. recognized rare edible macrofungi, its genomic sequence biosynthesis potential of secondary metabolites have not been investigated. In this study, using Illumina NovaSeq combined the PacBio platform, we sequenced de novo assembled whole genome NPCB_001, wild...
Laetiporus sulphureus mushroom is a complementary and alternative medicine that has anticancer, antioxidation, analgesic effects immunomodulatory activity; it used as treatment for cough rheumatism functional food can improve physical fitness. Even though L. garnered considerable biotechnological pharmacological interest due to its excellent cellulose-degrading ability diverse biological activities, biosynthetic potential regarding polysaccharides secondary metabolites not been thoroughly...
Agaricus bitorquis, an emerging wild mushroom with remarkable biological activities and a distinctive oversized shape, has gained increasing attention in recent years. Despite its status as important resource of edible fungi, knowledge about this is still limited. In study, we used the Illumina NovaSeq Nanopore PromethION platforms to sequence, de novo assemble, annotate whole genome mitochondrial (mitogenome) A. bitorquis strain BH01 isolated from Bosten Lake, Xinjiang Province, China....
Hericium rajendrae is an emerging species in the genus with few members. Despite being highly regarded due to its rarity, knowledge about H. remains limited. In this study, we sequenced, de novo assembled, and annotated complete genome of NPCB A08, isolated from Qinling Mountains Shaanxi, China, using Illumina NovaSeq Nanopore PromethION technologies. Comparative genomic analysis revealed similarities differences among genomes rajendrae, erinaceus, coralloides. Phylogenomic divergence time...
Abstract The Chinese medicinal fungi “Sanghuang” have been long recognized for their significant and valued properties, as documented in ancient medical literature. However, traditional folk medicine, various macrofungi sharing similar appearance, habitat, therapeutic effects with Sanghuang were erroneously used. These Sanghuang-like mainly belong to the Porodaedalea , Phellinus Inonotus genera within Hymenochaetaceae family. Despite establishment of Sanghuangporus genus identification...
As a natural antimicrobial agent, Melaleuca alternifolia oil (MAO) is generally recognized to be safe and effective in the inhibition of phytopathogenic fungi. Due lack comprehensive studies on MAO for controlling postharvest Aspergillus, we investigated preservative mechanism its components against Aspergillus ochraceus grapes evaluate their potential effectiveness as fruit preservatives.In our study, compositions were analysed by gas chromatography-mass spectrometry. The inhibitory effects...
Plant steroid glycosides, such as phytosterol steroidal saponins, and glycoalkaloids, are natural products with great pharmaceutical values. In this study, we characterized three UDP-glycosyltransferases (UGTs) involved in the glycosylation of sapogenin from Paris polyphylla. Substrate specificity analysis revealed that UGT73CR1 could glycosylate sapogenins alkaloids, highest affinity for diosgenin. The residues His27 Asp129 conserved corresponding positions plant glycosyltransferases, which...
The culinary medicinal mushroom Hericium erinaceus holds significant global esteem and has garnered heightened interest within increasingly ageing societies due to its pronounced neuroprotective anti-neuroinflammatory properties. Within this study, two novel diterpenes, 16-carboxy-13-epi-neoverrucosane (1) Erinacine L (2); three known xylosyl cyathane diterpenoids, A (3), C (4), F (5); four lanostane-type triterpenoids, cyclic dipeptides (10–12), in addition orcinol (13), were isolated from...
Abstract Cyathus olla , belonging to the genus within order Agaricales, is renowned for its bird's nest-like fruiting bodies and has been utilized in folk medicine. However, genome remains poorly understood. To investigate genomic diversity elucidate biosynthetic pathways medicinal compounds, we generated a high-quality assembly of C. with fourteen chromosomes. The comparative analysis revealed variations both genomes specific functional genes . Phylogenomic gene family variation analyses...
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This study presents the first comprehensive genomic analysis of Cryptoporus qinlingensis, a classical folk medicine and newly identified macrofungus from Qinling Mountains. Utilizing advanced sequencing technologies, including PacBio HiFi Hi-C, we achieved high-quality chromosome-level genome assembly. The genome, sized at 39.1 Mb, exhibits heterozygosity 0.21% contains 21.2% repetitive sequences. Phylogenetic revealed recent divergence C. qinlingensis Dichomitus squalens approximately...
Tyromyces fissilis (Berk. & M.A.Curtis) Donk 1933, a globally renowned white-rot basidiomycete belonging to the Polyporales order, holds significant potential for lignin degradation, yet its mitochondrial genome has received comparatively little attention. Our study concentrates on specimen designated T. NEFU_01, sourced from Forest Botanical Garden in Heilongjiang Province, China. Utilizing next-generation sequencing (NGS) technology, we have successfully delineated complete of this...