A5088223531- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Natural Compound Pharmacology Studies
- Lung Cancer Treatments and Mutations
- Bioactive natural compounds
- Crystallization and Solubility Studies
- Phytochemicals and Antioxidant Activities
- Neurological Disease Mechanisms and Treatments
- Sesquiterpenes and Asteraceae Studies
- X-ray Diffraction in Crystallography
- Essential Oils and Antimicrobial Activity
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Cancer Treatment and Pharmacology
- NF-κB Signaling Pathways
- Phytochemical Studies and Bioactivities
- HER2/EGFR in Cancer Research
- Synthesis of Organic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Lung Cancer Research Studies
- Biological and pharmacological studies of plants
- Plant chemical constituents analysis
- Free Radicals and Antioxidants
- Cancer-related molecular mechanisms research
- Phase Equilibria and Thermodynamics
Chengdu University of Traditional Chinese Medicine
2025
Northwest A&F University
2015-2024
Xiamen University
2024
Sichuan University
2003-2024
West China Hospital of Sichuan University
2018-2022
Xiangya Hospital Central South University
2021
Central South University
2021
Zhengzhou University
2020
Korea University
2016-2018
Henan Cancer Hospital
2017
Abstract The search for lead compounds with anti-neuroinflammatory activity from structurally ‘optimized’ natural products is a crucial and promising strategy in the quest to discover safe efficacious agents treating neurodegenerative diseases. A phytochemical investigation on aerial portions of Hypericum elatoides led isolation five nitrogenous polycyclic polyprenylated acylphloroglucinols (PPAPs), hyperelanitriles A–D ( 1 – 4 ) hyperelamine 5 ). Their structures were determined by...
Zanthoxylum schinifolium is an aromatic shrub, and its pericarp leaves are widely used in culinary applications East Asian countries. It has also long been traditional Oriental medicine for treating the common cold, stomach ache, diarrhea, jaundice. In this study, we identified two new compounds, zanthoxyloside (1) schinifolisatin A (13), along with 23 known coumarins (2-12) lignans (14-25), from a methanol extract of stems Z. . The chemical structures compounds were determined by mass, 1D-,...
Hericium erinaceus is a culinary-medicinal mushroom used traditionally in Eastern Asia to improve memory. In this work, we investigated the neuroprotective and neuritogenic effects of secondary metabolites isolated from MeOH extract cultured mycelium H. primary mechanisms involved. One new dihydropyridine compound (6) one natural product (2) together with five known compounds (1,3-5,7) were obtained their structures elucidated by spectroscopic analysis, including 2D NMR HRMS. The cell-based...
Artemisia iwayomogi has been used as a folk medicine for treating various diseases including inflammatory and immune-related diseases. Scopoletin (1) scopolin (2) were isolated from this species. showed more potent peroxyl radical-scavenging capacity, reducing cellular antioxidant capacity compared to (2). The inhibitory effect of 1 on the receptor activator nuclear factor κB ligand-induced osteoclastic differentiation RAW 264.7 macrophage cells was also than that 2. production general...
HIV is still an incurable disease, causing many problems in the daily lives of patients and affecting their overall quality life. Previous studies have shown that advanced AIDS more serious physical, psychological, social, economic than unmet needs at this time. The main objective study to better understand late-stage develop targeted palliative care services for them. Descriptive phenomenological methods were used. Advanced selected using purposive sampling a tertiary infectious disease...
Four new δ- and γ-lactone derivatives, hyperelatolides A-D (1-4, respectively), were discovered from the aerial portions of Hypericum elatoides R. Keller. Their structures elucidated by analysis NMR spectra, HRESIMS, quantum chemical calculations ECD X-ray crystallographic data. Hyperelatolides A (1) B (2) represent first examples δ-lactone derivatives characterized a (Z)-(5,5-dimethyl-2-(2-oxopropyl)cyclohexylidene)methyl moiety benzoyloxy group attached to β- γ-positions core,...
The anti-tumor activity and acceptable tolerability of pyrotinib plus chemotherapy have been demonstrated in phase III trials human epidermal growth factor receptor 2-positive metastatic breast cancer (BC). In this study, we assessed the efficacy safety neoadjuvant trastuzumab albumin-bound paclitaxel women with early or locally advanced BC.In single-arm exploratory II trial, patients untreated BC (stage IIA-IIIC) received 400 mg once daily, 4 mg/kg loading dose, followed by 2 a week, 125...
Pulsatilla koreana, a species endemic to Korea, is an important herb used in traditional medicine treat amoebic dysentery and malaria. In the present study, 23 oleanane-type triterpenoid saponins 1-23 eight lupane-type 24-31 were isolated from roots of P. koreana. Their structures elucidated on basis spectroscopic data. The methanol extract compounds next assessed for nematicidal activity against root-knot nematode (Meloidogyne incognita). showed strong after 48 h, with LC₅₀ value 92.8...
Continuous efforts to identify sEH inhibitors using activity-guided fractionation have revealed 12 known compounds, 2-13, from Rheum undulatum. Compounds 2-13 and 1, which was obtained the in-house library, were tested for inhibitory activity against sEH. 1-9, 11, shown activity, with IC50 values ranging 2.5 ± 0.5 53.2 4.4 μM. They subjected enzyme kinetic studies explore binding mode between ligand receptor. Based on our results, compounds 2, 5-9, 11 (mixed type) 3 (noncompetitive had a...
Nine new sesquiterpenes, hyperhubeins A–I (1–9), and 14 known analogues (10–23) were isolated from the aerial portions of Hypericum hubeiense. Their structures absolute configurations determined unambiguously via spectroscopic analysis, single-crystal X-ray diffraction, electronic circular dichroism calculations. Compounds 1–3 possess an unprecedented sesquiterpene carbon skeleton. Further, a plausible biosynthetic pathway farnesyl diphosphate (FPP) is proposed. The phytochemicals evaluated...
Background: Pyrotinib, a novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor, shows encouraging anticancer activity and acceptable tolerability in multiple phase II III randomized clinical trials, but the real-world data of pyrotinib, especially outcomes HER2-positive metastatic breast cancer, have been rarely reported. Here, we evaluated treatment pyrotinib practice patients with cancer (MBC). Methods: This was prospective, real-world, observational cohort study. Through Breast...
We sought to investigate attitudes toward breast-conserving therapy (BCS) in early-stage breast cancer (EBC) patients from P. R. China and assess the factors influencing their decision.There exists geographical difference decision perform mastectomy or BCS for EBC patients. To date, there has been no report on surgical choice mainland China.A structured questionnaire was delivered 1800 The elicited information about general patients' characteristics, BCS, roles of doctors spouses, levels...
Zanthoxylum schinifolium is an aromatic shrub, the pericarp and leaves of which are widely used in culinary applications East Asian countries. In present study, one new neolignan glycoside, zanthoxyloside A (1) together with 16 known glycosides (2–12) alkaloids (13–17), were isolated from methanol extract stems Z. schinifolium. The absolute configuration monoterpenoid glycoside (2) was determined. structures compounds established by dimensional (1D), 2D NMR mass spectrometry. nuclear...