A5100689894- Microbial Community Ecology and Physiology
- Wastewater Treatment and Nitrogen Removal
- Soil Carbon and Nitrogen Dynamics
- Plant Gene Expression Analysis
- Microbial Fuel Cells and Bioremediation
- Gut microbiota and health
- Plant Molecular Biology Research
- Reproductive System and Pregnancy
- Evaluation Methods in Various Fields
- Phosphorus and nutrient management
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Plant nutrient uptake and metabolism
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Diet and metabolism studies
- Graphene and Nanomaterials Applications
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- ATP Synthase and ATPases Research
- Selenium in Biological Systems
- Ammonia Synthesis and Nitrogen Reduction
- Dietary Effects on Health
- Hypothalamic control of reproductive hormones
- PARP inhibition in cancer therapy
Fuzhou University
2023-2025
Public Health Clinical Center of Chengdu
2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2024
Shanxi Medical University
2023-2024
Guangdong Pharmaceutical University
2023-2024
University of Chinese Academy of Sciences
2018-2023
Institute of Subtropical Agriculture
2020-2023
Chinese Academy of Sciences
1996-2023
Shanghai University of Finance and Economics
2023
Heilongjiang Bayi Agricultural University
2022
Polycomb repressive complexes (PRCs) play crucial roles in transcriptional repression and developmental regulation both plants animals. In plants, depletion of different members PRCs causes overlapping unique phenotypic defects. However, the underlying molecular mechanism determining target specificity functional diversity is not sufficiently characterized. Here, we quantitatively compared changes tri-methylation at H3K27 Arabidopsis mutants deprived various key PRC components. We show that...
Although there are plenty of evidence that single-nucleotide polymorphisms (SNPs) fall within coding sequences genes involved in recurrent pregnancy loss (RPL), it is still unknown whether the microRNAs (miRNAs) related with RPL. In this study, we established kind association by confirming significant differences genotype distribution rs41275794 (P= 0.0005) and rs12976445 0.001) pri-miR-125a 217 Han Chinese patients RPL compared 431 controls. Based on observation, two-locus haplotypes were...
The as-prepared nanofibers have better antibacterial properties. Incorporating PEG effectively reduced the CNT toxicity to human cells and also decreased attachment of bacteria.
We developed a high-throughput method for resequencing single nucleotide polymorphism (SNP) discovery using high-density microarrays. Over the two-year course of this study number improvements in sample preparation methods, hybridization assay, array handling, and analysis were implemented. DNA from 40 unrelated individuals three different ethnic origins was amplified, labeled, hybridized to arrays designed with probes representing genomic, coding, regulatory regions. Protocol including use...
Summary The phytohormone abscisic acid ( ABA )‐induced leaf senescence facilitates nutrient reuse and potentially contributes to enhancing plant stress tolerance. However, excessive causes serious reductions in crop yield, the mechanism by which is finely tuned at different levels still insufficiently understood. Here, we found that double mutant of core enzymes polycomb repressive complex 2 PRC 2) hypersensitive Arabidopsis thaliana . To elucidate interplay between PRC2 genome level,...
HIV is still an incurable disease, causing many problems in the daily lives of patients and affecting their overall quality life. Previous studies have shown that advanced AIDS more serious physical, psychological, social, economic than unmet needs at this time. The main objective study to better understand late-stage develop targeted palliative care services for them. Descriptive phenomenological methods were used. Advanced selected using purposive sampling a tertiary infectious disease...
Abstract Inorganic arsenic, an environmental contaminant, is known to cause cancer, developmental retardation, and many other serious diseases. Previous researches have shown that arsenic exerts its toxicity partially through generating reactive oxygen species (ROS). However, it still not well understood how ROS links exposure retardation of preimplantation embryo. Here we demonstrate high‐level arsenite induces severe redox imbalance by decreasing the levels glutathione increasing oxidative...
MicroRNAs (miRNAs) are short non-coding RNAs which modulate gene expression by binding to complementary segments present in the 3′UTR of mRNAs protein coding genes. MiRNAs play very important roles maintaining normal human body physiology conditions, meanwhile, abnormal miRNA expressions have been found related many diseases spanning from psychiatric disorders malignant cancers. Recently, emerging reports indicated that disturbed miRNAs contributed pathogenesis recurrent pregnancy loss...
Nitrate reducers containing narG or napA play an important role in the nitrogen cycle, but little is known about their functional differentiations relation to environmental changes. In this study, three types of nitrate genus Pseudomonas, including strains (G type), (A type) and both (GA were selected explore performances under varied oxygen concentrations. Their growth characteristics, consumption, dissimilatory nitrate-reducing activity investigated. Growth consumption all generally...
Antimicrobial resistance in Shigella spp. is a global public health concern. In this study, the AMR phenotypic profiles of 10 kinds antibiotics were compared with genotypic using genomic analysis 218 isolates from Taiyuan City, Shanxi Province, China, 2005 to 2016. Core genome Multilocus Sequence Typing (cgMLST) based on EnteroBase Escherichia/Shigella scheme was used obtain genetic relatedness isolates. Multiple-drug observed 96.79% spp., and antimicrobial agents varied between S. flexneri...
Recurrent spontaneous abortion (RSA) is a health problem that affects nearly 1% of fertile couples. However, the underlying etiology and mechanism(s) remain elusive. The aim this study was to investigate estrogen receptor (ESR) 1 gene polymorphisms for risk association unexplained recurrent (URSA) in Chinese Han population. entire coding region ESR1 sequenced from 129 URSA patients 183 healthy controls. There significant difference between G allele GG genotype distributions, (XbaI)...
SUMMARY The sugar status of a plant acts as signal affecting growth and development. phenomenon by which high levels sugars inhibit seedling establishment has been widely used to gain insight into sugar‐signaling pathways. Natural allelic variation identified at the ANAC060 locus. Arabidopsis Columbia ecotype produces short protein without transmembrane domain that is constitutively located nucleus, causing insensitivity when overexpressed. In this study, we generated genome‐wide DNA‐binding...
ABSTRACT Burkholderia cepacia complex (BCC) and Stenotrophomonas maltophilia are nosocomial pathogens that cause various infections exhibit high resistance to multiple antimicrobial agents. In this study, we aimed develop a duplex droplet digital PCR (ddPCR) assay for detecting BCC S. in bloodstream infections. We optimized the experimental conditions by setting annealing temperature 51°C determining optimal concentrations of primers probes, as well thermal cycle numbers. The feasibility...
As a classical traditional Chinese patent medicine, Shugan Yipi Granule is widely used in China to treat non-alcoholic fatty liver disease (NAFLD) recently. Our previous study confirmed that are effective NAFLD. However, its underlying mechanism still unknown. This aims investigate the of on NAFLD based network pharmacology prediction, liquid chromatography-mass spectrometry (LC-MS) analysis and vitro verification. We obtained active ingredients targets from 6 medicine databases, crucial...
Transgenic technology can transfer favorable traits regardless of reproductive isolation and is an important method in plant synthetic biology genetic improvement. Complex metabolic pathway modification pyramiding breeding strategies often require the introduction multiple genes at once, but current vector assembly systems for constructing multigene expression cassettes are not completely satisfactory. In this study, a new vitro gene stacking system, GuanNan Stacking (GNS), was developed....
Linggui Zhugan Decoction (LGZGD) has demonstrated promising potential in the treatment of obesity, prompting further investigation. In a study involving sixty-nine obese patients who received LGZGD for two months, changes body composition, gut microbiota, and plasma metabolomics were assessed. An animal experiment with ob/ob mice assessed antibiotics’ effects on weight, fat mass, metabolomics. Clinical results showed reduced fat, waist-to-hip ratio, improved microbiota diversity favoring...
Fertilization can cause obvious shifts in nitrate-reducing community composition agricultural ecosystems; however, little is known about the behaviors and functional characters of isolated nitrate reducers adapted to a specific environment. In this study, 849 bacteria were from various fertilization treatments long-term paddy field experiment; isolates further characterized functions with both culture-dependent independent methodologies. The results showed that CK (no fertilizer) treatment...
Genetic diversity in plants is remarkably high. Recent whole genome sequencing (WGS) of 67 rice accessions recovered 10,872 novel genes. Comparison the genetic architecture among divergent populations or between crops and wild relatives essential for obtaining functional components determining crucial traits. However, many major have gigabase-scale genomes, which are not well-suited to WGS. Existing cost-effective approaches including re-sequencing, exome-sequencing restriction enzyme-based...