A5061731265- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Free Radicals and Antioxidants
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Phytochemical Studies and Bioactivities
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Piperaceae Chemical and Biological Studies
- Natural Antidiabetic Agents Studies
- Bioactive natural compounds
- Bioactive Compounds and Antitumor Agents
- Cholinesterase and Neurodegenerative Diseases
- Biochemical Analysis and Sensing Techniques
- Genomics, phytochemicals, and oxidative stress
- melanin and skin pigmentation
- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Biological Activity of Diterpenoids and Biflavonoids
- Carbohydrate Chemistry and Synthesis
- Seaweed-derived Bioactive Compounds
- Alcohol Consumption and Health Effects
- Sesquiterpenes and Asteraceae Studies
Kyungpook National University
2023-2025
Chungnam National University
2013-2024
Daegu Gyeongbuk Institute of Science and Technology
2024
Sangji University
2021-2023
North Carolina State University
2023
Korea University
2020
Seoul Veterans Hospital
2013-2014
Chang Hua Hospital
2012
Gachon University Gil Medical Center
2001
Liaoning University of Traditional Chinese Medicine
1990
Zanthoxylum schinifolium is an aromatic shrub, and its pericarp leaves are widely used in culinary applications East Asian countries. It has also long been traditional Oriental medicine for treating the common cold, stomach ache, diarrhea, jaundice. In this study, we identified two new compounds, zanthoxyloside (1) schinifolisatin A (13), along with 23 known coumarins (2-12) lignans (14-25), from a methanol extract of stems Z. . The chemical structures compounds were determined by mass, 1D-,...
Vernonia cinerea (L.) Less. is a perennial herbaceous plant found mainly in tropical areas, particularly Southeast Asia, South America, and India. Various parts of V. have traditionally been used folk medicine to treat several diseases, such as malaria, fever, liver diseases. has so far yielded about 92 secondary metabolites. The majority these are sesquiterpene lactones, but triterpenes, flavonoids, steroids, phenolics, other compounds present well. crude extracts reportedly exhibit...
Acute myeloid leukemia (AML) is a bone marrow malignancy. Long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) plays an important role in several cancers. However, the of lncRNA UCA1 AML remained unclear.LncRNA expressions different cell lines were determined by RT-PCR. In human myelogenous (ML) K562 and HL60, effects knockdown on viability, migration, invasion, apoptosis assessed, respectively. Binding between microRNA (miR)-126, miR-126 RAC1 3'UTR detected RT-PCR...
This study investigated the potential of indirubin-3′-oxime (I3O) compound to mitigate temperature-induced male infertility in Drosophila melanogaster. Elevated temperatures significantly reduced egg-hatching rates, but I3O supplementation improved these suggesting it can partially restore fertility under heat stress. Additionally, was found inhibit soluble epoxide hydrolase (sEH), an enzyme involved metabolism epoxyeicosatrienoic acids, which are vital for reproductive health. exhibited sEH...
ABSTRACT The metazoan lifespan is determined in part by a complex signaling network that regulates energy metabolism and stress responses. Key hubs this include insulin/IGF‐1, AMPK, mTOR, sirtuins. Hippo/Mammalian Ste20‐like Kinase1 (MST1) pathway has been reported to maintain Caenorhabditis elegans , but its role not studied higher metazoans. In study, we report overexpression of Hpo, the MST1 homolog Drosophila melanogaster decreased with concomitant changes lipid aging‐associated gene...
A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures elucidated using 1D/2D nuclear magnetic resonance mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 ± 0.9 µM. molecular simulation revealed that compound interacts via hydrogen bonding residues His244, Thr261, Val283 tyrosinase. Additionally, 3 7 shown by...
The individual parts of Morus alba L. including root bark, branches, leaves, and fruits are used as a cosmetic ingredient in many Asian countries. This study identified several anti-melanogenesis constituents 70% ethanol extract M. leaves. ethyl acetate fraction the initial decreased activity tyrosinase, key enzyme synthetic pathway melanin. Twelve compounds were isolated from this their structures based on spectroscopic spectra. Then, authors investigated effects B16-F10 mouse melanoma...
Alkaloids 1–10 were isolated from the aerial parts of Tetrastigma hemsleyanum (APTH) and obtained species genus for first time. The chemical structures compounds identified by NMR, UV, MS analyses. Their anti-inflammatory activities investigated measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Among all isolates, 6, 7 10 showed potent inhibitory activity against LPS-stimulated NO cells (IC50: 31.9, 25.2 6.3 μM, respectively). Furthermore, APTH...
Current studies have found that butyrylcholinesterase (BuChE) replaces the biological function of acetylcholinesterase (AChE) in late stage Alzheimer's disease. Species genus Fallopia, rich polyphenols with diverse chemical structures and significant activities, are considered as an important resource for screening natural products to against AD. In this study, thirty-four compounds (1-34) were isolated from Fallopia dentatoalata (Fr. Schm.) Holub, their inhibitory effects AChE BuChE...
Two new neolignans, myrifralignans F-G (14 and 18), four diarylnonanoid derivatives, myrifragranones A-D (21-24), 18 known compounds were isolated structurally elucidated from nutmeg (Myristica fragrans Houtt.) seeds. The absolute configurations of these secondary metabolites determined using the electronic circular dichroism technique. inhibitory potential on soluble epoxide hydrolase (sEH) was investigated for first time. Among them, malabaricones B C (19 20) 21-24 displayed activities...
Four new aster saponins (1–4) together with five known analogues (5–9) were isolated from Aster tataricus. The chemical structures of 1–4 elucidated based on spectrometric and spectroscopic analysis comparison reported data. potential anti-inflammatory activities 1–9 evaluated subsequently by measuring lipopolysaccharide (LPS)-enhanced nitric oxide (NO) formation in murine macrophages. Among these, saponin B (6) exhibited the most potent inhibitory activity (IC50: 1.2 μM). Additionally,...