A5071036793- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Phytochemical Studies and Bioactivities
- Marine Sponges and Natural Products
- Natural Antidiabetic Agents Studies
- Allergic Rhinitis and Sensitization
- Phytochemicals and Antioxidant Activities
- Geotechnical Engineering and Soil Mechanics
- Cholinesterase and Neurodegenerative Diseases
- Geotechnical Engineering and Underground Structures
- Natural Compound Pharmacology Studies
- Geotechnical Engineering and Analysis
- Eicosanoids and Hypertension Pharmacology
- Bioactive Compounds and Antitumor Agents
- Mast cells and histamine
- Medicinal Plants and Neuroprotection
- Food Allergy and Anaphylaxis Research
- Toxin Mechanisms and Immunotoxins
- Sesquiterpenes and Asteraceae Studies
- Plant biochemistry and biosynthesis
- Free Radicals and Antioxidants
- Seaweed-derived Bioactive Compounds
- Chemical synthesis and alkaloids
Vietnam Academy of Science and Technology
2016-2025
Korea University
2022-2025
University of Bergen
2024
Hanoi University of Industry
2023
Chungnam National University
2016-2023
Ho Chi Minh City University of Technology
2020-2023
Vietnam National University Ho Chi Minh City
2020-2023
Wonkwang University
2021-2023
Institute of Marine Geology and Geophysics
2019-2023
Vernonia cinerea (L.) Less. is a perennial herbaceous plant found mainly in tropical areas, particularly Southeast Asia, South America, and India. Various parts of V. have traditionally been used folk medicine to treat several diseases, such as malaria, fever, liver diseases. has so far yielded about 92 secondary metabolites. The majority these are sesquiterpene lactones, but triterpenes, flavonoids, steroids, phenolics, other compounds present well. crude extracts reportedly exhibit...
Interleukin-33 (IL-33) is a cytokine produced by epithelial cells that plays key role in immune-mediated diseases, such as asthma, atopic dermatitis, and rheumatoid arthritis. In our research on the anti-allergic effects of Korean medicinal plants, we found an ethanol extract from roots Astragalus membranaceus exhibited significant IL-33 inhibitory effect. Using various chromatographic separation methods, eight compounds (1–8) were isolated extract. The effect protein was also investigated...
Abstract Inflammation, diabetes, and even malignancies are pharmacological effects connected by antioxidant capacity free radicals. Many antioxidants scavenge radicals originating from dietary sources such as fruits, vegetables, teas. To identify the bioactive components of Ligularia stenocephala , an effective method combining HPLC-QTOF-MS bioactivity evaluation was investigated for first time. Antioxidant agents were isolated L. a folk medicine used edema scrofula in Korea, Japan, China....
Soluble epoxide hydrolase (sEH) is essential for converting epoxy fatty acids, such as epoxyeicosatrienoic acids (EETs), into their dihydroxy forms. EETs play a crucial role in regulating blood pressure, mediating anti-inflammatory responses, and modulating pain, making sEH key target therapeutic interventions. Current research increasingly focused on identifying inhibitors from natural sources, particularly marine environments, which are rich bioactive compounds due to unique metabolic...
Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures determined by means spectroscopic methods one-dimensional and two-dimensional nuclear magnetic resonance (1-D 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) circular dichroism (CD). The DPPH radical scavenging cytotoxic activities against MCF7 (breast), HCT116 (colon) B16F10 (melanoma) cancer cell lines...
Using various chromatographic separations, sixteen compounds, including one new triterpene saponin named aegicoroside A (1), were isolated from the leaves of Vietnamese mangrove Aegiceras corniculatum. Their structures determined by spectroscopic methods such as 1D and 2D NMR HR-ESI-MS. The cytotoxic activities compounds against MCF7 (breast), HCT116 (colon), B16F10 (melanoma), A549 (adenocarcinoma) cancer cell lines also evaluated. Strong cytotoxicity was observed for sakurasosaponin (2)...
Using various chromatographic separations, four compounds, including one new steroid saponin named vernoamyoside E (1), were isolated from the leaves of Vietnamese medicinal plant Vernonia amygdalina Delile (Asteraceae). Their structures established by spectroscopic methods such as 1D- and 2D-NMR, HR-ESI-MS, HPLC analysis. The inhibitory activities against α-glucosidase α-amylase compounds V. reported for first time. results indicated that compound 1 significantly inhibited both activity.
The roots of Polygala tenuifolia Wild (Polygalaceae), which is among the most important components traditional Chinese herbal medicine, have been widely used for over 1000 years to treat a variety diseases. In current investigation secondary metabolites with anti-inflammatory properties from Korean medicinal plants, phytochemical constituent study led isolation 15 compounds (1–15) P. via combination chromatographic methods. Their structures were determined by means spectroscopic data such as...
A new compound, physalucoside (1), together with seven withanolides (2–8) and three flavonoids (9–11), were isolated from Physalis angulata L. (Solanaceae), a medicinal plant native to Vietnam. The chemical structures of these compounds elucidated by one- two-dimensional NMR spectra, high-resolution electrospray ionization mass spectrometry analyses, reactivity. anti-inflammatory cytotoxic activities also evaluated. These data suggest that the activity P. is due primarily its withanolide...
Using various chromatographic methods, five abietane-type diterpenes were isolated from the branches of Glyptostrobus pensilis for first time. The chemical structures isolates identified by modern spectroscopic techniques, including 1H and 13C nuclear magnetic resonance spectroscopy comparison with literature. In addition, binding potential compounds to replicase protein, SARS-CoV-2 main protease papain-like protease, examined using molecular docking studies. silico results suggested that G....
Stauntonia hexaphylla (Lardizabalaceae) has been used as a traditional herbal medicine in Korea and China for its anti-inflammatory analgesic properties. As part of bioprospecting program aimed at the discovery new bioactive compounds from Korean medicinal plants, phytochemical study S. leaves was carried out leading to isolation two oleanane-type triterpene saponins, 3-O-[β-d-glucopyranosyl (1→2)-α-l-arabinopyranosyl] oleanolic acid-28-O-[β-d-glucopyranosyl (1→6)-β-d-glucopyranosyl] ester...