A5076743499- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Microbial Natural Products and Biosynthesis
- Synthesis and Biological Activity
- Berberine and alkaloids research
- Synthesis and biological activity
- Phytochemical Studies and Bioactivities
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Biological Activities
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Eicosanoids and Hypertension Pharmacology
- Plant chemical constituents analysis
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Biochemical and Structural Characterization
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Alcohol Consumption and Health Effects
- Myofascial pain diagnosis and treatment
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Reactions of Organic Compounds
- Inflammatory Biomarkers in Disease Prognosis
Zhejiang Chinese Medical University
2023-2024
Seoul National University
2019-2024
Shandong First Medical University
2023
Chungnam National University
2018-2019
Hebei Normal University
2015-2016
Shijiazhuang University
2016
University of Science and Technology Beijing
2015
Silver sulfadiazine (SSD) particles in homogeneous dispersion state were prepared by an ultrasonic method and then nano- microparticles separated using centrifugation. SSD with narrow size distribution impregnated bacterial cellulose (BC) to produce BC–SSD composite membrane used as burn wound dressing. A scanning electron microscope (SEM) was examine the surface morphology of membranes. The incorporation confirmed X-ray diffraction (XRD). Antimicrobial tests vitro indicated that showed...
Alkaloids 1–10 were isolated from the aerial parts of Tetrastigma hemsleyanum (APTH) and obtained species genus for first time. The chemical structures compounds identified by NMR, UV, MS analyses. Their anti-inflammatory activities investigated measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Among all isolates, 6, 7 10 showed potent inhibitory activity against LPS-stimulated NO cells (IC50: 31.9, 25.2 6.3 μM, respectively). Furthermore, APTH...
Four new aster saponins (1–4) together with five known analogues (5–9) were isolated from Aster tataricus. The chemical structures of 1–4 elucidated based on spectrometric and spectroscopic analysis comparison reported data. potential anti-inflammatory activities 1–9 evaluated subsequently by measuring lipopolysaccharide (LPS)-enhanced nitric oxide (NO) formation in murine macrophages. Among these, saponin B (6) exhibited the most potent inhibitory activity (IC50: 1.2 μM). Additionally,...
Nitidumpeptins A and B (1 2), two novel cyclic hexapeptides, were isolated from the herb Zanthoxylum nitidum var. tomentosum. Their planar structures elucidated based on NMR MS spectrometric analysis, absolute configurations determined by Marfey's method. Structurally, 1 is a unique peptide with backbone bearing pyrrolidine-2,5-dione unit, which first occurrence moiety specifically in naturally occurring cyclohexapeptide. The total synthesis of 2 was achieved solution-phase parallel...
A series of novel coumarin-containing α-aminophosphonates were synthesized and evaluated for their antitumor activities against Human colorectal (HCT-116), human nasopharyngeal carcinoma (human KB) lung adenocarcinoma (MGC-803) cell lines in vitro. Compared with 7-hydroxy-4-methylcoumarin (4-MU), most the derivatives showed an improved activity. Compound 8j (diethyl 1-(3-(4-methyl-2-oxo-2H-chromen-7-yloxy) propanamido)-1-phenylethyl-Phosphonate), IC50 value 8.68 μM HCT-116 lines, was about...
A flavonoid glycoside, quercitrin (1), and two phenylpropanoyl sucrose derivatives, vanicoside B (2) lapathoside C (3), were isolated for the first time from herb Persicaria dissitiflora. Vanicoside exhibited antiproliferative activity against a panel of cancer cell lines in triple-negative breast (TNBC) MDA-MB-231 cells. The underlying mechanisms antitumor 2 investigated TNBC Upregulation cyclin-dependent kinase 8 (CDK8) was observed claudin-low molecular subtype modeling study indicated...
Novel asiatic acid derivatives containing α-aminophosphonates was designed and synthesized as antitumor agents. Compound <bold>3d</bold> blocked the T24 cell cycle at G<sub>1</sub>/S phase by p53-dependent pathway induced apoptosis through mitochondrial pathway.
Abstract Blood urea nitrogen (BUN) was an important biomarker for the development and prognosis of many diseases. Numerous studies had demonstrated that BUN a strong relationship with long-term mortality, survival prevalence some The diagnosis treatment, rate cancer were focus clinical research at present. However, between level not clear. To investigate prevalence, we performed statistical analysis population data from National Health Nutrition Examination Survey (NHANES) database. results...
The aerial parts of Tetrastigma hemsleyanum (APTH) have been used as a functional tea in China. purpose the current study was to identify bioactive constituents with inhibitory activity against soluble epoxide hydrolase (sEH) and inducible nitric oxide synthase (iNOS), which are jointly considered potential therapeutic targets for vascular system diseases. In present study, 39 compounds (1–39) were isolated from APTH. Among them, 8, 10, 12, 16, 17, 19, 32 displayed activities, IC50 values...
Zanthoxylum nitidum is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive in Z. nitidum, we isolated ten alkaloids (1-10), including one new natural compound (1), nine known (2-10), from an ethanolic extract the whole plant. The chemical structures elucidated based on combination comprehensive NMR HRESIMS analyses. Compounds...
A library of 24 congeners the natural product sulfuretin were evaluated against nine panels representing cancer diseases. While elicited very weak activities at 10 µM concentration, congener 1t was identified as a potential compound triggering growth inhibition diverse cell lines. Mechanistic studies in HCT116 colon cells revealed that dose-dependently increased levels cleaved-caspases 8 and 9 cleaved-PARP, while it concentration-dependently decreased CDK4, CDK6, Cdc25A, Cyclin D E resulting...
Peroxisome proliferator-activated receptor alpha (PPARα) and carnitine palmitoyltransferase 1 (CPT1) are important targets of lipid metabolism regulation for nonalcoholic fatty liver disease (NAFLD) therapy. In the present study, a set novel indole ethylamine derivatives (4, 5, 8, 9) were designed synthesized. The target product (compound can effectively activate PPARα CPT1a. Consistently, in vitro assays demonstrated its impact on accumulation oleic acid (OA)-induced AML12 cells. Compared...
Cancer is one of the most serious clinical problems worldwide, and considerable efforts have been devoted to discovering therapeutic agents with novel modes action. Natural synthetic coumarin derivatives attracted intense research interest due their diverse structural features remarkable array biological properties.In present study, we synthesized a series 4-MU containing urea-piperazine thioureapiperazine moieties evaluated antitumor activities find efficacy drugs.Cell proliferation,...
Three new germacrane sesquiterpenoid-type alkaloids with an unusual Δ8-7,12-lactam moiety, glechomanamides A–C (1–3), and two pairs of 7,12-hemiketal sesquiterpenoid epimers (4a/b, 5a/b) were isolated from Salvia scapiformis. Their structures elucidated by spectroscopic methods including HRESIMS, IR, UV, 1D 2D NMR also confirmed single-crystal X-ray diffraction analysis. The chemical transformation compounds 1–5 in a solution environment was analyzed spectroscopy. aza acetallactams (1–3)...
The problem of antibiotic abuse and drug resistance is becoming more serious. in recent years, polydopamine (PDA) nanoparticles have been recognized as a potential antimicrobial material for photothermal therapy (PTT) due to their excellent conversion efficiency unique ability.PDA capable rapidly converting light energy into heat under near-infrared (NIR) irradiation efficiently kill bacteria. In order solve the PDA&#039;s tendency aggregate precipitate, this study improved its stability...